A5003418429- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- melanin and skin pigmentation
- Essential Oils and Antimicrobial Activity
- Biochemical Analysis and Sensing Techniques
- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Plant biochemistry and biosynthesis
- Gout, Hyperuricemia, Uric Acid
- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and Bioactivity Studies
- Seed and Plant Biochemistry
- Free Radicals and Antioxidants
- Nuts composition and effects
- Skin Protection and Aging
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and biological activity of medicinal plants
- Biochemical and Molecular Research
- Petroleum Processing and Analysis
- Biotin and Related Studies
- Biochemical Acid Research Studies
University of Cagliari
2018-2024
The aim of this study was to test the inhibitory effect fruit extracts from Washingtonia filifera on skin aging-related enzymes. pulp did not exert a significant enzyme inhibition while seed W. exhibit anti-elastase, anti-collagenase, and anti-tyrosinase activities. Tyrosinase mildly inhibited stronger observed with respect elastase collagenase inhibition. Alcoholic provided better results than aqueous extracts. Among them, methanol showed prominent activities being IC50 value for comparable...
Skin aging is a progressive biological process of the human body, and it not only time-dependent. Differently substituted 3-phenylcoumarins proved to efficiently inhibit tyrosinase. In current work, new substitution patterns have been explored, studies were extended other important enzymes involved in processes skin aging, as elastase, collagenase hyaluronidase. From studied series, five compounds presented inhibitory activity against tyrosinase, one compound eight two hyaluronidase, being...
Pistacia lentiscus L. (P. lentiscus) is an evergreen shrub (Anacardiaceae family) primarily found in the Mediterranean region. The plant has been thoroughly characterized, resulting a high concentration of bioactive compounds as flavonoids and phenolics. Moreover, P. was revealed to possess great nutritional industrial importance because its variety biological activities, including antibacterial, anti-inflammatory, anti-atherogenic antioxidant properties. Many beneficial health properties...
Xanthine oxidase (XO) plays a critical role in purine catabolism, catalyzing the conversion of hypoxanthine to xanthine and uric acid, contributing superoxide anion production. This process is implicated various human diseases, particularly gout. Traditional XO inhibitors, such as allopurinol febuxostat, while effective, may present side effects. Our study focuses on Asphodelus microcarpus, plant renowned for traditional anti-inflammatory uses. Recent investigations into its phenolic-rich...
The chemical composition and biological properties of palm Washingtonia filifera (Lindl.) H. Wendl. seeds are seldom studied. Bearing this in mind, the W. fruits were analysed for their fatty acid phenolic antioxidant activity addition to cholinesterase xanthine oxidase inhibitory activities. Seed extracts revealed as a good source phenolics with significant activity. profile mainly consisted proanthocyanidins or procyanidin dimers B1-B4 among major compounds. highest butyrylcholinesterase...
Tyrosinase is a type-3 copper protein involved in the biosynthesis of melanin pigments; therefore, inhibition its enzymatic activity represents promising strategy for treatment hyperpigmentation-related disorders. To address this point, we previously designed class 4-(4-fluorobenzyl)piperazin-1-yl-based compounds, which proved to be more active inhibitors against tyrosinase from mushroom Agaricus bisporus than positive control kojic acid. Herein, report synthesis further series...
Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus extensive research in development novel preventive therapeutic strategies. However, their health benefits often limited by low bioavailability. Nanoparticle delivery systems can represent a solution to such limitations. Euphorbia characias is Mediterranean shrub known biological activities, inhibiting tyrosinase showing potential role skin-whitening agent. In this study, an ethanolic...
Extracts of aerial part Euphorbia characias were examined to check potential inhibitors for three selected enzymes involved in several metabolic disorders. Water and ethanol extracts from leaves flowers showed vitro inhibitory activity toward α-amylase, α-glucosidase, xanthine oxidase. IC50 values calculated all the ethanolic found exert best effect. In particular, α-glucosidase activity, resulted be 100-fold more active than standard inhibitor. The inhibition mode was investigated by...
Washingtonia filifera seeds have revealed to possess antioxidant properties, butyrylcholinesterase and xanthine oxidase inhibition activities. The literature has indicated a relationship between Alzheimer's disease (AD) type-2 diabetes (T2D). Keeping this in mind, we now evaluated the inhibitory properties of W. seed extracts on α-amylase, α-glucosidase enzyme activity Islet Amyloid Polypeptide (IAPP) fibrils formation.Three from were for their effect IC50 values calculated all extracts....
Melanin biosynthesis is enzymatically regulated by tyrosinase (TYR, EC 1.14.18.1), which efficiently inhibited natural and synthetic phenols, demonstrating potential therapeutic application for the treatment of several human diseases. Herein we report inhibitory effects a series (4-(4-hydroxyphenyl)piperazin-1-yl)arylmethanone derivatives, that were designed, synthesised assayed against TYR from Agaricus bisporus (AbTYR). The best activity was predominantly found compounds bearing selected...
Essential oils are well known for their biological properties, making them useful the treatment of various diseases. However, because poor stability and high volatility, potential cannot be fully exploited. The use nanoformulations to deliver essential can solve these critical issues amplify activities. We characterized an oil from Satureja thymbra via GC–MS HPLC–DAD provide qualitative quantitative data. was formulated in phospholipid vesicles which were size, surface charge, storage...
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Tyrosinase, a key protein in the biosynthesis of melanin pigments, is crucial determining skin pigmentation. Inhibiting tyrosinase activity promising approach for treating conditions related to excessive For synthesis more potent inhibitors, we combined two approaches, para-substitution and lipophilicity, enhance inhibitory properties (E)-2-(4-hydroxybenzylidene)hydrazine-1-carbotiamide, whose enzyme have been previously demonstrated. The newly synthesized compounds showed inhibition against...
Plant-derived products have been used for preventive and curative purposes from the ancient era to present day. Several studies demonstrated efficacy of either multicomponent-based extracts, enriched fractions, or isolated bioactives. However, they often display low solubility bioavailability, chemical instability, poor absorption, even toxicity, which restrict application in therapy. The use drug delivery systems, especially nanocarriers, can overcome these physicochemical pharmacokinetic...
Type 2 diabetes (T2D) is a progressive metabolic disorder of glucose metabolism. One the therapeutic approaches for treatment T2D reducing postprandial hyperglycaemia through inhibition digestive enzymes α-glucosidase and α-amylase. In this context, aimed at identifying natural products endowed with anti-T2D potential, we focused on Ptilostemon casabonae (L.) Greuter, species belonging to Asteraceae family. Enzymatic inhibition, antioxidant activity, phenolic composition cellular assays were...
In the aging process, skin morphology might be affected by wrinkle formation due to loss of elasticity and resilience connective tissues linked cleavage elastin enzymatic activity elastase. Little information is available about structural requirements efficiently inhibit elastase 1 (EC 3.4.21.36) expressed in keratinocytes. this study, a structure-based approach led identification pharmacophoric hypotheses that described main for binding porcine pancreatic as valuable tool development...
Type 2 diabetes (T2D), characterized by insulin resistance and β-cell dysfunction, requires continuous advancements in management strategies, particularly controlling postprandial hyperglycemia to prevent complications. Current antidiabetics, which have α-amylase α-glucosidase inhibitory activities, side effects, prompting the search for better alternatives. In addition, patients are vulnerable yeast infections because an unusual sugar concentration promotes growth of Candida spp. areas like...
A small library of 1-(4-nitrophenyl)-3-arylprop-2-en-1-one derivatives was synthesized to identify new human monoamine oxidase B selective inhibitors. Their inhibitory activity toward MAO-A and MAO-B isoforms evaluated determine their potency selectivity. All newly compounds were nanomolar inhibitors the isoform with IC
Abstract Coumarin scaffold has proven to be promising in the development of bioactive agents, such as xanthine oxidase (XO) inhibitors. Novel hydroxylated 3‐arylcoumarins were designed, synthesized, and evaluated for their XO inhibition antioxidant properties. 3‐(3’‐Bromophenyl)‐5,7‐dihydroxycoumarin (compound 11 ) proved most potent inhibitor, with an IC 50 91 nM, being 162 times better than allopurinol, one reference controls. Kinetic analysis compound 5...