A5035636559- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Diabetes and associated disorders
- MicroRNA in disease regulation
- Lipid Membrane Structure and Behavior
- Iron oxide chemistry and applications
- Astro and Planetary Science
- Ionosphere and magnetosphere dynamics
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- Reproductive System and Pregnancy
- Solar and Space Plasma Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Advanced Nanomaterials in Catalysis
- Reproductive biology and impacts on aquatic species
- Pancreatic function and diabetes
- Agriculture and Rural Development Research
- Sperm and Testicular Function
- Milk Quality and Mastitis in Dairy Cows
- Advanced Electron Microscopy Techniques and Applications
- Crystallography and molecular interactions
Université de Rennes
2018-2025
Inserm
2019-2025
Centre National de la Recherche Scientifique
2019-2025
Structure Fédérative de Recherche en Biologie et Santé de Rennes
2018-2024
Centre Hospitalier Universitaire de Rennes
2024
Instituts Universitaires de Technologie
2024
Fédération de recherche en imagerie multi-modalité
2020-2024
CEA DAM Île-de-France
2022
Unité Matériaux et Transformations
2022
Technologie Médicale (France)
2022
After decades of observations solar energetic particles from space-based observatories, relevant questions on particle injection, transport, and acceleration remain open. To address these scientific topics, accurate measurements the properties in inner heliosphere are needed. In this paper we describe Energetic Particle Detector (EPD), an instrument suite that is part payload aboard Solar Orbiter mission. will approach Sun as close 0.28 au provide extra-ecliptic beyond ∼30° heliographic...
Staphylococcus aureus is a major pathogen responsible for bovine mastitis, the most common and costly disease affecting dairy cattle. S. naturally releases extracellular vesicles (EVs) during its growth. EVs play an important role in bacteria-bacteria bacteria-host interactions are notably considered as nanocarriers that deliver virulence factors to host tissues. Whether mastitis context still unknown. In this work, we showed Newbould 305 (N305), isolate, has ability generate vitro with...
Research Article30 April 2019Open Access Transparent process Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation Marion Maurel INSERM U1242, “Chemistry, Oncogenesis Stress Signaling”, University Rennes, France Centre de Lutte Contre le Cancer Eugène Marquis, VIB Department Medical Protein Research, UGent, Gent, Belgium Apoptosis Centre, School Natural Sciences, NUI Galway, Ireland Search for more papers by this author Joanna Obacz Tony...
Abstract We present a time‐of‐flight mass spectrometer design for the measurement of ions in ~30 keV to 10 MeV range protons (up ~40 and ~150 He heavy ions, respectively) 1 electrons, covering half sky with 80 apertures. The instrument, known as “Mushroom,” owing its shape, solves field view problem magnetospheric heliospheric missions that employ three‐axis stabilized spacecraft, yet still require extended angular coverage; Mushroom is also compatible spinning spacecraft. most important new...
The oocyte microenvironment constituted by the follicular fluid (FF) is a key for optimal development of female gametes. Its composition reflects physiological state ovarian follicle. particularity FF to contain huge diversity extracellular vesicles specific women, in same way as seminal plasma men. Here, we described and compared morphological aspects broad subcategories human FF-related Extracellular Vesicles (EVs). EVs participate pathological processes have potential applications...
The declining birth rates and fertility challenges in Europe have intensified global concerns over rising infertility, particularly among women. This study decisively investigates follicular fluid-related extracellular vesicles (FF-EVs) from infertile patients with polycystic ovary syndrome (PCOS) or diminished ovarian reserve (DOR) undergoing vitro fertilization (IVF), comparing them to a healthy control group. We identified significant variations protein content polydispersity crude fluid...
Abstract Glioblastoma is a devastating tumor of the central nervous system characterized by poor survival and an extremely dark prognosis, making its diagnosis, treatment monitoring highly challenging. Numerous studies have highlighted extracellular vesicles (EVs) as key players growth, invasiveness resistance, they carry disseminate oncogenic material in local microenvironment at distance. However, whether their quality quantity reflect individual health status changes homeostasis still not...
The NFL-peptide was discovered almost 20 years ago, and its targeting properties were assessed alone or in combination with lipid nanocapsules (LNC), magnetic porous silicon nanorods, gold nanoparticles. Results highlighted a better of cancer cells, particular glioblastoma pancreas cancer. Considering the large use liposomes (LPs) as an hydrophilic drug delivery system, this study explored possibility to functionalize three different sequences NFL-peptides: native (NFL-peptide), biotinylated...
Beta cell failure and apoptosis following islet inflammation have been associated with autoimmune type 1 diabetes pathogenesis. As conveyors of biological active material, extracellular vesicles (EV) act as mediators in communication immune effectors fostering the idea that EV from inflamed beta cells may contribute to autoimmunity. Evidence accumulates exosomes promote diabetogenic responses, but relative contributions larger well variations composition cell's vesiculome due environmental...
Extracellular vesicles (EVs) are well-known membrane-limited particles secreted by both healthy and cancerous cells. They considered as biomarkers for early cancer diagnosis involved in many pathologies physiological pathways. could serve diagnostic tools liquid biopsies, therapeutics regenerative medicine, or drug delivery vehicles. Our aim is here to encapsulate luminescent nanoprobes the aqueous compartment of human EVs extracted from reproductive fluids. The analysis labeling content...
Calcium drives the structural transitions of iron–organic matter associations from colloidal aggregates to a non-colloidal micrometric network, subsequently controlling their mobility and iron surface reactivity.
According to their high electron density and ultrasmall size, gold nanoclusters (AuNCs) have unique luminescence photoelectrochemical properties that make them very attractive for various biomedical fields. These applications require a clear understanding of interaction with biological membranes. Here we demonstrate the ability AuNCs as markers lipidic bilayer structures such synthetic liposomes extracellular vesicles (EVs). The can selectively interact or EVs through an electrostatic...
Extracellular vesicles (EVs) are lipid-based nanosized particles that convey biological material from donor to recipient cells. EVs play key roles in glioblastoma progression because stem-like cells (GSCs) release pro-oncogenic, pro-angiogenic, and pro-inflammatory EVs. However, the molecular basis of EV remains poorly understood. Here, we report identification pseudokinase MLKL, a crucial effector cell death by necroptosis, as regulator constitutive secretion GSCs. We find genetic, protein,...
NFL-TBS.40-63 peptide is a recently discovered derived from the light neurofilament chain (NFL). In this study, we demonstrated that Biotinylated-NFL-peptide (BIOT-NFL) can spontaneously self-assemble into well-organized nanofibers (approximately 5 nm width and several micrometers in length) solutions, whereas typical self-assembly was not systematically observed other peptides with or without coupling. The critical aggregation concentration allows BIOT-NFL-peptide to aggregate auto...
Essential oils are well known for their biological properties, making them useful the treatment of various diseases. However, because poor stability and high volatility, potential cannot be fully exploited. The use nanoformulations to deliver essential can solve these critical issues amplify activities. We characterized an oil from Satureja thymbra via GC–MS HPLC–DAD provide qualitative quantitative data. was formulated in phospholipid vesicles which were size, surface charge, storage...
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Small extracellular vesicles (sEV) released by healthy beta cells are promising candidates for diabetes therapy thanks to their aptitude modulate inflammation, induce or maintain pancreatic function and prevent pathogenic mechanisms. To advance the clinical development of therapeutics, there is a crucial need scalable production methods. Stirred tank bioreactors (STR) widely used in industry due ability provide homogeneous gas nutrient supply, online monitoring, efficient scale up....
Several studies previously showed that the NFL-TBS.40-63 peptide (NFL-peptide) is capable to specifically penetrating several glioblastoma cell lines (rat, mouse, human) and inhibiting their division
Gold nanoclusters (Au NCs) are attractive luminescent nanoprobes for biomedical applications. In vivo biosensing and bioimaging requires the delivery of Au NCs into subcellular compartments. this view, we explore here possible encapsulation ultra-small-sized red blue emitting liposomes various sizes chemical compositions. Different methods were investigated to prepare vesicles containing in their lumen. The efficiency process was correlated structural morphological aspect NCs' encapsulating...
view Abstract Citations (23) References (20) Co-Reads Similar Papers Volume Content Graphics Metrics Export Citation NASA/ADS Observations of Cygnus X-1 in the energy range 100 keV - 3 MeV. Mandrou, P. ; Niel, M. Vedrenne, G. Dupont, A. Hurley, K. Cyg was observed 1976 June 5-6, keV-3 MeV by means an 80 sq cm balloon-borne gamma-ray telescope, while source 'low' state. The spectrum is given and compared with previous results at lower higher energies. Publication: Astrophysical Journal Pub...