A5103243035- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Cyclopropane Reaction Mechanisms
- Organic Chemistry Cycloaddition Reactions
- Catalytic Cross-Coupling Reactions
- Carbon dioxide utilization in catalysis
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Oxidative Organic Chemistry Reactions
- Asymmetric Hydrogenation and Catalysis
- Toxin Mechanisms and Immunotoxins
- Insect and Pesticide Research
- Molecular spectroscopy and chirality
- Botanical Research and Chemistry
The University of Queensland
2024
Nanjing Tech University
2023
Wuhan University
2017
A method for electrooxidative C(sp3)–H amination via intermolecular oxidative C(sp3)–H/N–H cross-coupling has been developed under metal- and oxidant-free conditions. The bonds adjacent to oxygen, nitrogen, sulfur atoms could all react smoothly with various amines give the corresponding products moderate good yields (30–93%). In addition, of benzylic allylic are also tolerated in this reaction. preliminary mechanistic study indicates that C–H cleavage tetrahydrofuran is probably not involved...
A photoredox-catalyzed 1,2-amidoheteroarylation of unactivated alkenes with O-acyl hydroxylamine derivatives and heterocycles is presented. range heterocycles, including quinoxaline-2(1H)-ones, azauracils, chromones, quinolones, are capable for this process, allowing the direct synthesis valuable heteroarylethylamine derivatives. Structurally diverse reaction substrates, drug-based scaffolds, were successfully applied, demonstrating practicality method.
A novel method of palladium-catalyzed oxidative carbonylation ketones, amines, and carbon monoxide for the synthesis 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals.
Pimelea poisoning of Australian cattle is attributed to the natural toxin simplexin binding bovine PKC. Molecular dynamics simulations reveal simplexin's high affinity for PKC, and identify SAR future molecular interventions against poisoning.
Unexpectedly facile dearomative intramolecular (4+3) cycloadditions of thiophenes with epoxy enolsilanes, providing sulfur-bridged cycloadducts, are reported. A total fifteen thiophene substrates have been found to undergo cycloaddition smoothly produce endo and exo adducts in yields up 83 % moderate good diastereoselectivity. Complete conservation enantiomeric purity was observed when the optically enriched epoxide used. The desulfurizing transformations skeleton cycloadducts provide...
Abstract Unexpectedly facile dearomative intramolecular (4+3) cycloadditions of thiophenes with epoxy enolsilanes, providing sulfur‐bridged cycloadducts, are reported. A total fifteen thiophene substrates have been found to undergo cycloaddition smoothly produce endo and exo adducts in yields up 83 % moderate good diastereoselectivity. Complete conservation enantiomeric purity was observed when the optically enriched epoxide used. The desulfurizing transformations skeleton cycloadducts...
The carbene carbon of the multidentate ligand PY4Im induces a consistent trans influence in number Co( iii ) complexes.