A5058406835- Nanoparticle-Based Drug Delivery
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Advanced Proteomics Techniques and Applications
- Bacterial Infections and Vaccines
- Food Quality and Safety Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Mycotoxins in Agriculture and Food
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Probiotics and Fermented Foods
- Infective Endocarditis Diagnosis and Management
- Microplastics and Plastic Pollution
- Mass Spectrometry Techniques and Applications
- Nanoplatforms for cancer theranostics
Universidad Complutense de Madrid
2016-2024
NOAA Chemical Sciences Laboratory
2021
An approach for safely delivering AgNPs to cancer cells and the evaluation of affected cellular mechanism are presented. The use mesoporous silica nanoparticles (MSNs) as nanovehicles decorated with transferrin (Tf, targeting agent) provides a nanoplatform nucleation immobilization (MSNs-Tf-AgNPs). We performed physico-chemical characterization nanosystems evaluated their therapeutic potential using bioanalytical strategies estimate efficiency targeting, degree internalization in two cell...
Silver nanoparticles (AgNPs) are currently used in many different industrial, commercial and health fields, mainly due to their antibacterial properties. Due this widespread use, humans the environment increasingly exposed these types of nanoparticles, which is reason why evaluation potential toxicity associated with AgNPs great importance. Although some toxic effects induced by have already been shown, elucidation more complete mechanisms yet be achieved. In sense, since integration...
This study delves into the biomolecular mechanisms underlying antitumoral efficacy of a hybrid nanosystem, comprised silver core@shell (Ag@MSNs) functionalized with transferrin (Tf). Employing SILAC proteomics strategy, we identified over 150 de-regulated proteins following exposure to nanosystem. These play pivotal roles in diverse cellular processes, including mitochondrial fission, calcium homeostasis, endoplasmic reticulum (ER) stress, oxidative stress response, migration, invasion,...
A combination of omics techniques (transcriptomics and metabolomics) has been used to elucidate the mechanisms responsible for antitumor action a nanosystem based on Ag core coated with mesoporous silica which transferrin anchored as targeting ligand against tumor cells (Ag@MSNs-Tf). Transcriptomics analysis carried out by gene microarrays RT-qPCR, while high-resolution mass spectrometry metabolomics. This multi-omics strategy enabled discovery effect this different key molecular pathways...
Synthesis, characterization and evaluation of transferrin-decorated mesoporous silica-coated silver nanoparticles as a novel hemocompatible core@shell nanosystem for selective targeting apoptosis induction in cancer cells.