A5049263171- Mycobacterium research and diagnosis
- Herpesvirus Infections and Treatments
- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Bacterial Infections and Vaccines
- Virus-based gene therapy research
- Galectins and Cancer Biology
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Telomeres, Telomerase, and Senescence
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Radiation Therapy and Dosimetry
- Infectious Diseases and Tuberculosis
- Cytomegalovirus and herpesvirus research
- Renal and related cancers
- Vector-borne infectious diseases
- Infectious Diseases and Mycology
- Pneumonia and Respiratory Infections
- Protein Tyrosine Phosphatases
- Hepatitis C virus research
- Infective Endocarditis Diagnosis and Management
- Toxin Mechanisms and Immunotoxins
- Respiratory viral infections research
- Poxvirus research and outbreaks
Universidad Autónoma de Madrid
2010-2025
Koç University
2020
Universidad de Zaragoza
2008
ABSTRACT Alterations in glycoconjugate profiles are thought to promote changes cell‐to‐cell and cell‐to‐intracellular extracellular scaffold interactions human disease. The nearly unlimited number of “glycoforms” that may exist nature difficult study due glycosylation modifications being associated with non‐genome coded posttranscription post‐translation processes. Specific products generated by dependent on concentration sub‐cellular locations glycan synthesis processing enzymes. An...
Tuberculosis (TB) still represents a major global health problem affecting over 10 million people worldwide. The gold-standard procedures for TB diagnosis are culture and nucleic acid amplification techniques. In this context, both lipoarabinomannan (LAM) urine test rapid molecular tests have been game changers. However, the low sensitivity of former cost prohibitive infrastructure requirements to scale-up in endemic regions latter, make improvement diagnostic landscape priority. Most forms...
Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis ( Mtb ) have raised significant interest for their potential in cell communication, nutrient acquisition, immune evasion. However, the relevance of vesicle secretion during infection remains unknown due to limited understanding mycobacterial biogenesis. We previously shown that a transposon mutant LCP-related gene virR mut manifested strong...
Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis ( Mtb ) have raised significant interest for their potential in cell communication, nutrient acquisition, immune evasion. However, the relevance of vesicle secretion during infection remains unknown due to limited understanding mycobacterial biogenesis. We previously shown that a transposon mutant LCP-related gene virR mut manifested strong...
Mycobacterium abscessus (MABS) is an emerging pathogen causing severe infections, particularly in cystic fibrosis (CF) patients. A prospective multicentre study included CF patients from four hospitals Madrid between January 2022 and 2024. Respiratory samples were collected, MABS isolates analysed to determine their antibiotic resistance profiles, growth dynamics, infection kinetics, intracellular behaviour, pathogenicity. Intracellular bacterial macrophage viability evaluated through THP-1...
ABSTRACT Since the discovery of extracellular vesicles (EVs) in mycobacterial species 15 years back, we have learned that this phenomenon is conserved Mycobacterium genus and has critical roles bacterial physiology host-pathogen interactions. tuberculosis ( Mtb ), (TB) causative agent, produces EVs both vitro vivo including a diverse set biomolecules with demonstrated immunomodulatory effects. Moreover, (MEVs) been shown to possess vaccine properties carry biomarkers diagnostic capacity....
To assess the role of telomerase activity and telomere length in pancreatic CSCs we used different CSC enrichment methods (CD133, ALDH, sphere formation) primary patient-derived cancer cells. We show that have higher longer telomeres than bulk tumor Inhibition activity, using genetic knockdown or pharmacological inhibitor (BIBR1532), resulted marker depletion, abrogation formation vitro reduced tumorigenicity vivo. Furthermore, identify a positive feedback loop between stemness factors...
Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis ( Mtb ) have raised significant interest for their potential in cell communication, nutrient acquisition, immune evasion. However, the relevance of vesicle secretion during infection remains unknown due to limited understanding mycobacterial biogenesis. We previously shown that a transposon mutant LCP-related gene virR mut manifested strong...
Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis ( Mtb ) have raised significant interest for their potential in cell communication, nutrient acquisition, immune evasion. However, the relevance of vesicle secretion during infection remains unknown due to limited understanding mycobacterial biogenesis. We previously shown that a transposon mutant LCP-related gene virR mut manifested strong...
Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis ( Mtb ) have raised significant interest for their potential in cell communication, nutrient acquisition, immune evasion. However, the relevance of vesicle secretion during infection remains unknown due to limited understanding mycobacterial biogenesis. We previously shown that a transposon mutant LCP-related gene virR mut manifested strong...
Abstract Pathogenic and nonpathogenic mycobacteria secrete extracellular vesicles (EVs) under various conditions. EVs produced by Mycobacterium tuberculosis ( Mtb ) have raised significant interest for their potential in cell communication, nutrient acquisition, immune evasion. However, the relevance of vesicle secretion during infection remains unknown due to limited understanding mycobacterial biogenesis. We previously shown that a transposon mutant LCP-related gene virR mut manifested...
Abstract To date, it is still unclear how cancer stem cells (CSCs) regulate their stemness properties, and to what extent they share common features with normal cells. Telomerase regulation a key factor in cell maintenance. In this study, we investigate telomerase affects biology pancreatic ductal adenocarcinoma (PDAC), delineate the mechanisms by which activity CSC properties are linked. Using primary patient-derived cells, show that CSCs have higher longer telomeres than bulk tumor...