A5009263445- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Inflammasome and immune disorders
- Nanoparticle-Based Drug Delivery
- Immune Response and Inflammation
- Carbohydrate Chemistry and Synthesis
- Inhalation and Respiratory Drug Delivery
- Infectious Diseases and Mycology
- vaccines and immunoinformatics approaches
- Advanced Drug Delivery Systems
- SARS-CoV-2 and COVID-19 Research
- Kawasaki Disease and Coronary Complications
- Pneumocystis jirovecii pneumonia detection and treatment
- Infectious Diseases and Tuberculosis
- Antibiotic Resistance in Bacteria
- Cancer therapeutics and mechanisms
- Influenza Virus Research Studies
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Veterinary medicine and infectious diseases
Papworth Hospital
2024
University of Cambridge
2019-2022
MRC Laboratory of Molecular Biology
2021-2022
Centre National de la Recherche Scientifique
2010-2014
Institut de Pharmacologie et de Biologie Structurale
2010-2014
Université Toulouse III - Paul Sabatier
2010-2014
Université de Toulouse
2011-2014
Laboratoire de Chimie de Coordination
2011
Hôpital Rangueil
2011
Significance In 1901, when Robert Koch proposed that the bacilli causing human and bovine tuberculosis were not identical, this view caused much controversy. Now, 113 y later, we know agent, Mycobacterium bovis , together with other animal strains, forms a separate phylogenetic lineage apart from lineages, but molecular reasons why strains only play minor roles in epidemiology remain unknown. Herein, show by genetic transfer virulence experiments specific mutations regulator contribute to...
Jump starting pathogen evolution Mycobacteria are mostly environmental saprotrophs, but during human history, some have become our pathogens. In the past 50 years or so, intractable and virulent infections of Mycobacterium abscessus emerged in people with cystic fibrosis. Bryant et al. investigated how these mycobacteria evolved into pathogens so quickly (see Perspective by Brugha Spencer). Chronic lung offer plenty evolutionary scope for emergence clones after horizontal gene transfer...
Several specific lipids of the cell envelope are implicated in pathogenesis M. tuberculosis (Mtb), including phthiocerol dimycocerosates (DIM) that have clearly been identified as virulence factors. Others, such trehalose-derived lipids, sulfolipids (SL), diacyltrehaloses (DAT) and polyacyltrehaloses (PAT), believed to be essential for Mtb virulence, but details their role remain unclear. We therefore investigated respective contribution DIM, DAT/PAT SL by studying a collection mutants, each...
Mycobacterium tuberculosis (Mtb) remains a major challenge to global health, made worse by the spread of multi-drug resistance. Currently, efficacy and safety treatment is limited difficulties in achieving sustaining adequate tissue antibiotic concentrations while limiting systemic drug exposure tolerable levels. Here we show that nanoparticles generated from polymer-antibiotic conjugate ('nanobiotics') deliver sustained release active upon hydrolysis acidic environments, found within...
ABSTRACT Since the discovery of extracellular vesicles (EVs) in mycobacterial species 15 years back, we have learned that this phenomenon is conserved Mycobacterium genus and has critical roles bacterial physiology host-pathogen interactions. tuberculosis ( Mtb ), (TB) causative agent, produces EVs both vitro vivo including a diverse set biomolecules with demonstrated immunomodulatory effects. Moreover, (MEVs) been shown to possess vaccine properties carry biomarkers diagnostic capacity....
Abstract Genetic determinants of susceptibility to Mycobacterium tuberculosis ( Mtb ) are poorly understood but could provide insights into critical pathways involved in infection, informing host-directed therapies and enabling risk stratification at individual population levels. Through a genome-wide forward genetic screen, we identify the Toll-like Receptor 8 (TLR8), as key regulator intracellular killing . Pharmacological TLR8 activation enhances phylogenetically diverse clinical isolates...
Inflammation observed in SARS-CoV-2-infected patients suggests that inflammasomes, pro-inflammatory intracellular complexes, regulate various steps of infection. Lung epithelial cells express inflammasome-forming sensors and constitute the primary entry door SARS-CoV-2. Here, we describe NLRP1 inflammasome detects SARS-CoV-2 infection human lung cells. Specifically, is cleaved at Q333 site by multiple coronavirus 3CL proteases, which triggers assembly, cell death limits production infectious...