A5081772180- Amino Acid Enzymes and Metabolism
- Drug Transport and Resistance Mechanisms
- Ion channel regulation and function
- Pharmacological Effects and Toxicity Studies
- Ion Transport and Channel Regulation
- Chemotherapy-induced organ toxicity mitigation
- Metal complexes synthesis and properties
- Bacterial Genetics and Biotechnology
- Lanthanide and Transition Metal Complexes
- Advanced biosensing and bioanalysis techniques
- Protein Kinase Regulation and GTPase Signaling
- Cystic Fibrosis Research Advances
- Nanopore and Nanochannel Transport Studies
University of Freiburg
2024
Universitätsmedizin Göttingen
2014
University of Toronto
2013
University of Göttingen
2008
Renal cell carcinoma (RCC) is usually chemoresistant. This chemoresistance could be overcome if specific cytostatics are applied for which the RCC expresses an uptake transporter. In present study, we investigated expression of solute carrier (SLC) transporters in different lines and their ability to interact with chemotherapeutics. We tested five SLCs by reverse transcription-PCR TaqMan real-time PCR. two lines, A498 7860, observed a highly significant SLC22A3 (hOCT3). Uptake organic cation...
Unlike aquaporins or potassium channels, ammonium transporters (Amts) uniquely discriminate from and water. This feature has certainly contributed to their repurposing as receptors during evolution. Here, we describe the receptor Sd-Amt1, where an Amt module connects a cytoplasmic diguanylate cyclase transducer via HAMP domain. Structures of protein with without bound were determined 1.7- 1.9-Ångstrom resolution, depicting ON OFF states confirming presence binding site for two cations that...
Anion exchanger 1 (AE1; Band 3; SLC4A1) is the founding member of solute carrier 4 (SLC4) family bicarbonate transporters that includes chloride/bicarbonate AEs and Na+-bicarbonate co-transporters (NBCs). These membrane proteins consist an amino-terminal cytosolic domain involved in protein interactions a carboxyl-terminal carries out transport function. Mutation conserved arginine residue (R298S) NBCe1 (SLC4A4) linked to proximal renal tubular acidosis results impaired function, suggesting...
Chronic lymphatic leukemia (CLL) is often associated with nephritic syndrome. Effective treatment of CLL by chlorambucil and bendamustine leads to the restoration renal function. In this contribution, we sought elucidate impact organic anion transporters (OATs) on uptake as a probable reason for superior efficacy over in CLL. We examined effects structural analogs p-aminohippurate (PAH), melphalan, chlorambucil, bendamustine, OAT1-mediated [(3)H]PAH OAT3- OAT4-mediated [(3)H]estrone sulfate...
Renal cancer cell (RCC) carcinoma is usually chemoresistant. This chemoresistance would be overcome when a cytostatic applied for which the RCC possess an uptake transporter. Therefore, in present study we investigated expression of solute carrier (SLC) transporters different samples and their ability to interact with chemotherapeutical drugs. We tested five lines as well normal tumor tissue 30 SLC by RT‐PCR TaqMan real‐time PCR. In two lines, A498 7860, observed highly significant SLC22A3...