A5046444824- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Enzyme function and inhibition
- Animal Virus Infections Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Hemoglobin structure and function
- Histone Deacetylase Inhibitors Research
- Aortic aneurysm repair treatments
- Synthesis and Catalytic Reactions
- vaccines and immunoinformatics approaches
- Nanoplatforms for cancer theranostics
- Biochemical and Molecular Research
- Aortic Disease and Treatment Approaches
- Intracranial Aneurysms: Treatment and Complications
- Virus-based gene therapy research
- Neuropeptides and Animal Physiology
- Redox biology and oxidative stress
Biomedical Research Center of the Slovak Academy of Sciences
2019-2023
Institute of Virology of the Slovak Academy of Sciences
2019-2023
Resistance to chemotherapy represents a persisting medical problem, ranking among main causes of failure and cancer mortality. There is possibility utilize repurpose already existing therapeutics which were not primarily intended for oncological treatment. Overactivation adrenergic receptors signaling dysregulation promotes tumor progression, metastatic potential, immune system evasion, angiogenesis drug resistance. The non-selective beta-blocker propranolol, approved in infantile...
Abstract Background Carbonic anhydrase IX (CA IX) is a hypoxia-induced enzyme regulating tumour pH and facilitating cell migration/invasion. It primarily expressed as transmembrane cell-surface protein, but its ectodomain can be shed by ADAM17 to extracellular space. This study aims elucidate the impact of CA shedding on cancer cells. Methods We generated non-shed mutant deletion amino acids 393–402 from stalk region studied phenotypic effects compared full-length, shedding-competent using...
The coexistence of cancer and other concomitant diseases is very frequent has substantial implications for treatment decisions outcomes. Beta-blockers, agents that block the beta-adrenergic receptors, have been related also to cancers. In model multicellular spheroids formed by colorectal cells we described a crosstalk between beta-blockade propranolol tumour microenvironment. Non-selective beta-blocker decreased ability adapt hypoxia reducing levels HIF1α carbonic anhydrase IX in 3D...
Experimental data indicate that during persistent infection, lymphocytic choriomeningitis virus (LCMV) may both directly or indirectly modulate regulatory cellular processes and alter functions are not critical for survival, but essential cell homeostasis. In order to shed more light on these processes, two-dimensional differential in-gel electrophoresis (2D-DIGE) MALDI-TOF tandem mass spectrometry were used determine the proteome response of HeLa line LCMV infection. Quantitative analysis...
Slovakia is a country with only 5.45 million inhabitants. However, the past two years of COVID-19 pandemic have shown huge inter-regional differences. These were represented by different numbers diagnosed SARS-CoV-2 cases and vaccination rates in regions, as well willingness inhabitants to comply anti-pandemic measures or undergo testing. The occurrence such regional disparities provided rational basis for monitoring epidemic situation within smaller areas, e.g. at city level. Trencin...
Human carbonic anhydrase IX (CAIX), a unique member of the α family, is transmembrane glycoprotein with high enzymatic activity by which CAIX contributes to tumorigenesis through pH regulation. Due its aberrant expression, considered be marker tumor hypoxia and poor prognostic factor several human cancers. Hypoxia-activated catalytic function dependent on posttranslational modification short intracellular domain. In this work, we have identified that C-terminal Ala459 residue, common across...
Cross-sectional seroprevalence study of SARS-CoV-2 IgG antibodies was accomplished in the Slovak Academy Sciences to inform authorities research institutions about situation at their workplaces, assess risk next exposure SARS-CoV-2, and guide decisions on institutional measures sustaining essential evolving epidemic situation. Study participants provided informed consent, anamnestic information, self-collected dry blood spot samples that were analyzed by ELISA for S protein-specific...
Abdominal aortic aneurysms (AAA) are a significant cause of premature deaths worldwide. Since there is no specific treatment for reducing AAA progression, it crucial to understand the pathogenesis leading aneurysm wall weakening/remodeling and identify new proteins involved in this process which could subsequently serve as novel therapeutic targets. In study, we analyzed presence hypoxia-related carbonic anhydrase IX (CA IX), hypoxia-inducible factor 1α (HIF-1α), AKT key molecule...
BRIEF RESEARCH REPORT Acta Virol., 22 June 2023 https://doi.org/10.3389/av.2023.11652
The presented seroprevalence study focused on specific antibodies to the SARS-CoV-2 virus is second survey conducted among SAS employees. Its realization enabled monitoring of impact booster vaccination doses and spread Omicron variant in a defined group people. total seropositivity involved employees autumn 2022 was 96.04%. In vaccinated participants (1,189) rate 99.5%, while unvaccinated (176) it 72.73%. By October 2022, when conducted, 65.05% (888) have had positive PCR/Ag test for at...