A5060410353- Sperm and Testicular Function
- Birth, Development, and Health
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Magnetic properties of thin films
- Renal and related cancers
- Semiconductor materials and interfaces
- Adipose Tissue and Metabolism
- Silicon and Solar Cell Technologies
- Per- and polyfluoroalkyl substances research
- Advanced NMR Techniques and Applications
- Pluripotent Stem Cells Research
- Quantum and electron transport phenomena
- Marine Biology and Environmental Chemistry
- Estrogen and related hormone effects
- Physics of Superconductivity and Magnetism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mycotoxins in Agriculture and Food
- Lipid metabolism and disorders
- Quantum, superfluid, helium dynamics
- Liver Disease Diagnosis and Treatment
- Heavy Metal Exposure and Toxicity
- Epigenetics and DNA Methylation
- Topological Materials and Phenomena
- Fibroblast Growth Factor Research
Lanzhou University
2022-2024
Wenzhou Medical University
2018-2023
First Affiliated Hospital of Wenzhou Medical University
2022-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2020
Shanghai University
2011
Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrinopathies disorder in women of reproductive age non-alcoholic fatty liver (NAFLD) one diseases worldwide. Previous research has indicated potential associations between PCOS NAFLD, but underlying pathophysiology still not clear. The present study aims to identify differentially expressed genes (DEGs) NAFLD through bioinformatics method, explore associated molecular mechanisms.
Abstract Leydig cells (LCs) play crucial roles in producing testosterone, which is critical the regulation of male reproduction and development. Low levels testosterone will lead to hypogonadism. LC transplantation a promising alternative therapy for However, source LCs limits this strategy clinical applications. Thus far, others have reported that can be derived from stem by gene transfection, but safe effective induction method has not yet been reported. Here, we report Leydig-like human...
Triphenyltin chloride (TPT) is present in a wide range of human foods. TPT could disrupt testis function as potential endocrine disruptor Leydig cells. However, the effect on pubertal cell development still unclear. The objective current study was to explore whether exposure affected developmental process and clarify underlying mechanisms. Male Sprague Dawley rats at 35 days age were randomly divided into four groups received normal corn oil (control), 0.5, 1 or 2 mg/kg/day for 18 days....
Zearalenone (ZEA), a fungal mycotoxin, is present in wide range of human foods. By virtual screening, we have identified that ZEA potential endocrine disruptor Leydig cells. The effect on cell development still unclear. objective the study was to explore whether affected developmental process and clarify underlying mechanism. Adult male Sprague-Dawley rats (60 days old) were randomly divided into three groups these received single intraperitoneal injection 75 mg/kg ethane dimethane sulfonate...
Perfluorododecanoic acid (PFDoA) has been used as a surfactant and may have reproductive toxicity. However, whether PFDoA influences Leydig cell development during prepuberty remains unknown. In the present study, 21-day-old male Sprague–Dawley rats were gavaged 0, 5, or 10 mg/kg from postnatal day 21 to 35. decreased serum concentrations of testosterone, luteinizing hormone, follicle-stimulating hormone at doses 5 without influencing number proliferation. down-regulated expression genes...
With increasing research on idiopathic pulmonary fibrosis (IPF) and gastroesophageal reflux disease (GERD), more studies have indicated that GERD is associated with IPF, but the underlying pathological mechanisms remain unclear. The aim of present study to identify analyse differentially expressed genes (DEGs) between IPF explore relevant molecular via bioinformatics analysis. Four GEO datasets (GSE24206, GSE53845, GSE26886, GSE39491) were downloaded from database, DEGs identified online...
Fibroblast growth factor 1 (FGF1) is reported to be expressed in the testis. How FGF1 affects stem Leydig cell development remains unclear. Here, we report effects of on rat an ethane dimethane sulfonate (EDS)-treated model. (100 ng/testis) significantly increased serum testosterone level, PCNA-positive percentage and number, but down-regulated expression Lhcgr, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd11b1 cells per se, after its daily intratesticular injection from post-EDS day 14 for days....
Ziram is a dimethyldithiocarbamate fungicide, which may influence the male reproductive system as potential endocrine disruptor. We interrogated disruption of ziram on rat progenitor Leydig cell development. Prepubertal Sprague-Dawley rats were orally treated with 0, 2, 4, or 8 mg/kg for 2 weeks. investigated effects serum testosterone levels, number, and Sertoli gene protein expression, SIRT1/PGC-1α phosphorylation AKT1, ERK1/2, AMPK in vivo. also reactive oxidative species (ROS) level,...
Based on LabVIEW, the measurement system of I-V characteristics solar energy is designed with a simulator, Keithley 2400 Source Meter and GPIB port. The can quickly describe characteristic curves calculate basic parameters focus analysis series resistance (R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> ) shunt xmlns:xlink="http://www.w3.org/1999/xlink">sh</sub> ). results demonstrate that precisely measure every parameter cell...
Abstract Nonreciprocity in chiral magnets is promising for applications spintronics. Spin-wave nonreciprocity happens when applying an external magnetic field to a magnet while stream of particles parallel the flows through it. Here, we found micromagnetic simulations that, absence lattice chirality, excitation spectra spin waves conical state depend on relative orientations spin-polarized current and applied along helix axis. When both are same direction, component helical axis increases...
Heterostructures composed of different elements are a suitable platform for many novel physical phenomena. Here, quantum oscillations related to the lattice symmetry in hexagonal close-packed (hcp) ${\mathrm{Co}}_{2}/{\mathrm{Si}}_{n}$ superlattices, such as parameters, electronic structure, and magnetism, revealed studied by density-functional theory. Densely packed atomic layers stack an $ABAB$ sequence superlattice reach bilayer-like structure interlayer coupling presence Co/Si interface....
Composed of the three spiral magnetic vectors, structure skyrmion lattice (SkL) can be destructed by spin excitations in possibly two ways: one is to make decoherence all helices through phase change a certain vector, and other inhibit or components while enhancing others so that it becomes single double vectors. Here, we present micromagnetic study on two-dimensional SkL under in-plane microwave field. By calculating parameters describing mode, find configuration tends an enhanced...