A5077881997- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Hemispheric Asymmetry in Neuroscience
- Cerebral Venous Sinus Thrombosis
- Spatial Neglect and Hemispheric Dysfunction
- Pharmacological Effects and Toxicity Studies
- Trauma and Emergency Care Studies
- Meningioma and schwannoma management
- Vestibular and auditory disorders
- Glaucoma and retinal disorders
- Single-cell and spatial transcriptomics
- Traumatic Ocular and Foreign Body Injuries
- Immune cells in cancer
- Emergency and Acute Care Studies
- Posttraumatic Stress Disorder Research
- Cardiac Arrest and Resuscitation
- Memory and Neural Mechanisms
- Epilepsy research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
Allen Institute
2023
Allen Institute for Brain Science
2023
Walter Reed Army Institute of Research
1985-1987
Uniformed Services University of the Health Sciences
1987
The mammalian brain consists of millions to billions cells that are organized into many cell types with specific spatial distribution patterns and structural functional properties1-3. Here we report a comprehensive high-resolution transcriptomic cell-type atlas for the whole adult mouse brain. was created by combining single-cell RNA-sequencing (scRNA-seq) dataset around 7 million profiled (approximately 4.0 passing quality control), approximately 4.3 using multiplexed error-robust...
Using data derived from a 15-year follow-up study of 520 veterans surviving penetrating brain wounds received in the Vietnam war, we have developed predictive formula and tables for posttraumatic epilepsy based on time elapsed postinjury presence specific clinical computed tomographic scan risk factors. Such patients remain at some increased even ten to 15 years postinjury, although most can be 95% certain avoiding if they been seizure free three posttrauma. Epilepsy onset latency was...
We examined the relationship of preinjury intelligence, a lesion-severity variable (brain-tissue loss volume), and lesion location to persistence cognitive deficits in Vietnam veterans with penetrating brain wounds. Using stepwise multiple linear regression procedures, we found that intelligence predicted significant amount variance on postinjury testing, being better predictor for tests requiring number complementary processes (e.g., tests) than measuring specific process face recognition)....
We compared the neurologic and cognitive performance of 15 young veterans who suffered unilateral penetrating missile wounds to basal forebrain years ago in Vietnam War with uninjured controls patients lesions elsewhere brain. The subjects performed worse on tests episodic memory, reasoning, arithmetic had more prolonged unconsciousness after injury; but their usually favorably that intelligence, attention, language was not consistent a demented patient. data suggest is functionally related...
• Persistent memory problems were reported by a 39-year-old man who suffered penetrating brain wound while serving in Vietnam 15 years earlier. Neuropsychological testing indicated an unusually isolated impairment. Computed tomography revealed transection of the columns fornix cerebri with no temporal-lobe involvement and minimal thalamic damage. We suggest that has role maintenance information accessibility to both encoding recall during post-working processing organization verbal and/or...
The relationship of preinjury left-hand dominance for motor performance to postinjury distal skills following penetrating brain wounds in patients without overt hemiplegia was examined. We studied 13 controls, right-hemisphere brain-damaged patients, and 11 left-hemisphere on tasks measuring reaction time, strength, coordination. Our results indicated that no persistent deficits were seen left-handed adults who suffered a wound. These findings are compatible with the relative sparing...