A5027522145- Neurogenesis and neuroplasticity mechanisms
- Developmental Biology and Gene Regulation
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- Genomics and Chromatin Dynamics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Pluripotent Stem Cells Research
- Memory and Neural Mechanisms
- Single-cell and spatial transcriptomics
- Photoreceptor and optogenetics research
The University of Tokyo
2023-2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangdong Medical College
2024
Guangzhou Medical University
2024
Jiangsu University
2022
Identification of factors that regulate chromatin condensation is important for understanding gene regulation. High-mobility group AT-hook (HMGA) proteins 1 and 2 are abundant nonhistone play a role in many biological processes including tissue stem-progenitor cell regulation, but the nature their protein function remains unclear. Here we show HMGA2 mediates direct polynucleosomes forms droplets with nucleosomes. Consistently, most endogenous localized to transposase 5- DNase I-inaccessible...
Adult neural stem cells (NSCs) in the mouse subventricular zone (SVZ) serve as a lifelong reservoir for newborn olfactory bulb neurons. Recent studies have identified slowly dividing subpopulation of embryonic stem-progenitor (NPCs) origin adult NSCs. Yet, little is known about how these NPCs are maintained until adulthood while other extinguished by completion brain development. The extracellular matrix (ECM) an essential component cell niches and thus key determinant fate. Here we...
With the advancement of high-throughput sequencing and bioinformatics, an increasing number overlooked small noncoding RNAs (sncRNAs) have emerged. These sncRNAs predominantly comprise transfer RNA-derived fragments (tsRNAs), PIWI-interacting (piRNAs), Ro-associated non-coding (RNYs or Y-RNAs), nucleolar (snoRNAs), nuclear (snRNAs). Each these RNA types possesses distinct biological properties plays specific roles in both physiological pathological processes. The differential expression...
SUMMARY Both adult neural stem (type B) cells and ependymal E) in the mouse ventricular-subventricular zone (V-SVZ) are derived from slowly dividing (or quiescent) embryonic stem-progenitor (NPCs) that set aside during development. However, it has remained unclear whether fate diversification between type B E actually occurs embryogenesis. Here we performed single-cell transcriptomic analysis of NPCs identified cell subpopulations transcriptionally similar to or cells. The B- like appeared...