A5022731921- Extracellular vesicles in disease
- Wound Healing and Treatments
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Genetics and Neurodevelopmental Disorders
- Dermatologic Treatments and Research
- Burn Injury Management and Outcomes
Southern Medical University
2022-2024
Cincinnati Children's Hospital Medical Center
2024
Chromatin-remodeling protein BRG1/SMARCA4 is pivotal for establishing oligodendrocyte (OL) lineage identity. However, its functions oligodendrocyte-precursor cell (OPC) differentiation within the postnatal brain and during remyelination remain elusive. Here, we demonstrate that Brg1 loss profoundly impairs OPC in with a comparatively lesser effect spinal cord. Moreover, BRG1 critical after injury. Integrative transcriptomic/genomic profiling reveals exhibits dual role by promoting networks...
Abstract The association between microRNAs (miRNAs) and the development of skin fibrosis has been established. Consequently, investigation miRNA is crucial for management cutaneous fibrotic diseases. Recent investigations have linked miR-378a to several Here, we discovered that miR-378a-3p effectively inhibited proliferative, migratory, COL1A1 expression effects induced by TGF-β1 in fibroblasts. Additionally, found exerts its anti-fibrotic properties directly binding FSTL1, a downstream...
Abstract Background The use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn treatment. There is growing evidence that extracellular vesicles, including exosomes, are primary mediators the benefits therapy. Herein, we thus explored effects exosomes produced by iPSCs-derived (iPSCs-KCs-Exos) in model deep second-degree wound healing and evaluated mechanistic basis observed activity. Methods iPSCs-KCs-Exos were...
Abstract Background: The use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn treatment. There is growing evidence that extracellular vesicles, including exosomes, are primary mediators the benefits therapy. Herein, we thus explored effects exosomes produced by iPSCs-derived (iPSCs-KCs-Exos) in model deep second-degree wound healing and evaluated mechanistic basis observed activity. Methods: iPSCs-KCs-Exos were...