A5073255430- Nutrition and Health in Aging
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Nutritional Studies and Diet
- Diabetes Management and Research
- Sodium Intake and Health
- Cardiovascular Health and Disease Prevention
- Parkinson's Disease Mechanisms and Treatments
- GDF15 and Related Biomarkers
- Acute Ischemic Stroke Management
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition, Health and Food Behavior
- Clinical Nutrition and Gastroenterology
- Diabetes Treatment and Management
- Consumer Attitudes and Food Labeling
- Cancer, Stress, Anesthesia, and Immune Response
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Dialysis and Renal Disease Management
- Adrenal Hormones and Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Calcium signaling and nucleotide metabolism
- Retinal Imaging and Analysis
Tokyo Metropolitan Institute of Gerontology
2023-2024
Niigata Institute of Technology
2023
Niigata University
2021-2023
Tokyo Metropolitan Geriatric Hospital
2012-2022
Sarcopenia is a serious problem because of its poor prognosis. Growth differentiation factor 15 (GDF15) associated with mitochondrial dysfunction, inflammation, insulin resistance and oxidative stress, which may play crucial roles for the development sarcopenia. We aimed to examine whether serum GDF15 level muscle mass, strength lower extremity function in older patients cardiometabolic disease.Serum levels were measured 257 diseases (including 133 diabetes) who had visited frailty clinic,...
Aims Although evidence has accumulated that white matter hyperintensity (WMH) is associated with the deterioration of cognitive function and impairment activities daily living (ADL), clinical relevance WMH in elderly patients diabetes mellitus not still clear. The aim this study was to examine whether volume ADL glucose control variability can affect these patients. Methods This cross-sectional investigated associations instrumental (IADL), as well metabolic vascular risk factors a total 178...
<b><i>Introduction:</i></b> Frailty is a crucial health issue among older adults. Growth differentiation factor 15 (GDF15) associated with inflammation, oxidative stress, insulin resistance, and mitochondrial dysfunction, which are possible pathogeneses of frailty. However, few longitudinal studies have investigated the association between GDF15 incidence Therefore, we whether high serum levels <b><i>Methods:</i></b> A total 175 adults (mean...
To investigate whether sarcopenic obesity is associated with the progression of atherosclerotic lesions in older patients diabetes and to identify components that best reflect atherosclerosis.
Abstract Background Dementia is an important health issue for older people and requires early intervention in the mild cognitive impairment (MCI) stage to manage risk factors. Both dynapenia (DP) abdominal obesity (AO) are associated with inflammation oxidative stress, which may be involved pathogenesis of impairment. Therefore, this cross-sectional study, we aimed evaluate association between MCI dynapenic (DAO), a combination DP AO. Methods A total 417 outpatients cardiometabolic diseases...
We examined the impact of a history coronary artery disease (CAD) or cerebrovascular (CVD) and physical activity habits on functional disability among community-dwelling Japanese adults. This population-based retrospective cohort study included 10,661 people aged 39-98 years in Japan (5054, men). Median follow-up was 3.7 years. During period, 209 disabilities occurred overall population. In multivariable analysis, CVD (hazard ratio [HR] 1.57 [95% CI: 1.00-2.45]) no habit (HR 1.74...
Aim We examined whether the Dementia Assessment Sheet for Community‐based Integrated Care System 8‐items (DASC‐8) is useful screening frailty and as a comprehensive geriatric assessment (CGA). Methods Outpatients ( N = 431; 269 women; M age 78.9 ± 6.8 years) with cardiometabolic disease from clinic participated. Frailty status was assessed using modified Cardiovascular Health Study criteria, Clinical Scale Kihon Checklist. Cognition, higher‐level activities of daily living, sarcopenia,...
This study investigates the associations between sodium intake and diabetes complications in a nationwide cohort of elderly Japanese patients with type 2 aged 65-85. Data from 912 individuals regarding their dietary at baseline is analyzed assessed by Food Frequency Questionnaire based on food groups. Primary outcomes are times to diabetic retinopathy, overt nephropathy, cardiovascular disease (CVD), all-cause mortality during six years. We find that mean quartiles ranges 2.5 g 5.9 g/day....
Although vaccination against coronavirus disease (COVID-19) has several side effects, hypopituitarism due to hypophysitis rarely been reported.
Destructive thyroiditis and secondary adrenal insufficiency are major endocrinological immune-related adverse events of immune checkpoint inhibitors (ICIs). However, the timing at which each event occurs most frequently after drug administration varies, cases where multiple occur simultaneously rare. We encountered a patient who concurrently suffered from thyrotoxicosis insufficiency. An 80-year-old woman with history type 2 diabetes mellitus (DM) was diagnosed stage IVA squamous cell...
White matter abnormalities may reflect cerebral microvessel disease. Diffusion tensor imaging (DTI) can help detect early changes in white integrity each tract. However, studies investigating the relationship between subclinical atherosclerosis markers and alterations DTI findings are limited. This study aimed to examine associations cardiovascular risk factors indices of atherosclerosis—ankle brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), carotid artery intima-media...
Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients altered white matter integrity. However, the relationship between these structural changes in and sarcopenia remains poorly understood.The study included 284 older (aged ≥65 years) who visited Tokyo Metropolitan Geriatric Hospital Frailty Clinic. We used diffusion measure fractional anisotropy (FA) mean diffusivity (MD) evaluate investigated associations...
Diffusion tensor imaging (DTI) can be used for the early detection of abnormal changes in integrity cerebral white matter tracts, and we have previously reported that these are associated with indices atherosclerotic lesions. Although been demonstrated to incidence frailty older adults, no studies investigated this relationship patients at high risk vascular disease. In longitudinal study, followed outpatients cardiometabolic diseases a maximum 6 years (median, 3 years) evaluated association...
Aim This longitudinal study aimed to determine whether categorization by the Dementia Assessment Sheet for Community‐based Integrated Care System 8‐items (DASC‐8) is associated with risk of frailty onset, disability, and mortality. Methods We analyzed data from outpatients aged 65 years older evaluated DASC‐8 at Frailty Clinic. The outcomes during 3‐year follow‐up period were (Study A) onset (Kihon Checklist ≥8) B) disability (new certification nursing care needs) or Multivariate Cox...
This observational longitudinal study aimed to explore the risk factors for disabilities in older Japanese individuals with diabetes at a frailty clinic, an outpatient clinic specializing comprehensive geriatric assessments patients.
目的:水疱性類天疱瘡は,表皮基底膜部抗体の出現により表皮下水疱を生じる自己免疫疾患である.近年,DPP-4阻害薬使用中の高齢糖尿病患者における水疱性類天疱瘡の発症報告が散見されるようになったが,どのような臨床的特徴を有するのか不明な点が多い.水疱性類天疱瘡を発症した高齢2型糖尿病患者の臨床的特徴について,糖尿病がない水疱性類天疱瘡患者と比較し検討を行った.方法:対象は2012年9月から2016年9月に,当院皮膚科にて水疱性類天疱瘡と確定診断された65歳以上の2型糖尿病患者15名(年齢81.1±5.5歳,男性11名,女性4名)および非糖尿病高齢患者20名(年齢87.7±7.3歳,男性8名,女性12名)である.発症時のADL,併存疾患,使用薬剤,および臨床経過について調査し,Wilcoxon検定及びχ2検定を用いて群間比較した.結果:2型糖尿病患者における水疱性類天疱瘡発症時のHbA1c値は7.3±1.6%であった.糖尿病患者においては,DPP-4阻害薬を15例中13例(87%)が内服しており,平均服用期間は17.7±10.7カ月であった.糖尿病患者では,非糖尿病患者と比較して男性が...
Few reports have described the characteristics of hyperglycemic hyperosmolar syndrome (HHS) in elderly. We investigated background and clinical features 14 elderly patients with HHS.HHS was diagnosed based on a blood glucose level >600 mg/dL an effective plasma osmolality [2 (Na) + glu/18] >320 mOsm/kg. For cases HHS, we medical social backgrounds patients, their findings, outcomes.The mean patient age 83 years, body mass index 17.8 kg/m2. Half had history either cerebral infarction or hip...
A 47-year-old woman with a history of diabetes mellitus (DM) and obesity was admitted to our hospital for glucose control. She detected have hypertension (HT) diagnosed primary aldosteronism (PA) based on the high level aldosterone renin ratio results upright furosemide-loading test according criteria Japanese Society Hypertension (JSH) guidelines. Computed tomography revealed left renal tumor adrenocortical adenoma. underwent nephrectomy adrenalectomy. The pathological findings were...
症例は84歳男性.55年来の2型糖尿病でインスリン療法が行われていた.胆道系腺癌を認め,胆管ステントが留置されていた.2週間前より発熱と食思不振が出現しインスリン療法を自己中断した.2日前より意識障害(JCSII-20)が出現し,救急搬送された.血糖値632 mg/dL,血漿浸透圧391 mOsm/kg・H2O,血清Na 163 mEq/L,尿ケトン体±より,高浸透圧高血糖状態と診断し,敗血症の合併もあり,緊急入院した.補液及びインスリン投与,抗生剤投与によって血糖値や血清Na値は緩徐に改善した.意識障害も改善したが,入院第3病日の食事再開の際に嚥下困難を認め,嚥下内視鏡検査で嚥下反射遅延と唾液の咽頭貯留を指摘された.頭部MRIでは橋正中部のT2強調像高信号域を認めており,浸透圧性脱髄症候群と考えられた.嚥下リハビリテーションによって経口摂取が可能となるまで回復した.高浸透圧高血糖症候群に浸透圧性脱髄症候群を合併することは比較的稀である.さらに本症例では嚥下機能障害が主症状であり,他疾患との鑑別に困難を要した貴重な症例と考えられたため報告する.