A5058485569- Nutrition and Health in Aging
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Angiogenesis and VEGF in Cancer
- Dementia and Cognitive Impairment Research
- GDF15 and Related Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cerebrovascular and Carotid Artery Diseases
- Wound Healing and Treatments
- Renal Diseases and Glomerulopathies
- Diabetes and associated disorders
- Eicosanoids and Hypertension Pharmacology
- Immune cells in cancer
- Antimicrobial Peptides and Activities
- Electrolyte and hormonal disorders
- Inflammatory mediators and NSAID effects
- Blood disorders and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- Body Composition Measurement Techniques
- Advanced MRI Techniques and Applications
- Cancer Diagnosis and Treatment
Tokyo Metropolitan Institute of Gerontology
2023-2024
Kitasato University
2012-2022
Tokyo Metropolitan Geriatric Hospital
2019-2022
Sarcopenia is a serious problem because of its poor prognosis. Growth differentiation factor 15 (GDF15) associated with mitochondrial dysfunction, inflammation, insulin resistance and oxidative stress, which may play crucial roles for the development sarcopenia. We aimed to examine whether serum GDF15 level muscle mass, strength lower extremity function in older patients cardiometabolic disease.Serum levels were measured 257 diseases (including 133 diabetes) who had visited frailty clinic,...
Thromboxane A2 (TXA2) induces platelet adhesion through thromboxane prostanoid (TP) receptor. Platelets contain many pro-angiogenic factors and are recruited to the site of vascular injury. However, cellular molecular mechanisms platelet-dependent angiogenesis, especially involvement TP signalling, have not been fully elucidated. The present study hypothesized that TP-dependent would contribute angiogenesis in a mouse hindlimb ischaemic model. Blood flow recovery was suppressed by TXA2...
<b><i>Introduction:</i></b> Frailty is a crucial health issue among older adults. Growth differentiation factor 15 (GDF15) associated with inflammation, oxidative stress, insulin resistance, and mitochondrial dysfunction, which are possible pathogeneses of frailty. However, few longitudinal studies have investigated the association between GDF15 incidence Therefore, we whether high serum levels <b><i>Methods:</i></b> A total 175 adults (mean...
To investigate whether sarcopenic obesity is associated with the progression of atherosclerotic lesions in older patients diabetes and to identify components that best reflect atherosclerosis.
There are many reports of incompletely glycosylated O-linked oligosaccharides on the IgA1 hinge region in certain IgA nephropathy patients. In addition, other have noted a relationship between tonsillectomy and nephropathy.Immunoglobulins from extracts tonsillectomized tissue sources were analysed by isoelectric focusing (IEF) enzyme-linked immunosorbent assay (ELISA).The IEF profile tonsillar differed that serum it was enriched cationic IgA. However, tonsillitis controls patients exhibited...
Abstract Background Dementia is an important health issue for older people and requires early intervention in the mild cognitive impairment (MCI) stage to manage risk factors. Both dynapenia (DP) abdominal obesity (AO) are associated with inflammation oxidative stress, which may be involved pathogenesis of impairment. Therefore, this cross-sectional study, we aimed evaluate association between MCI dynapenic (DAO), a combination DP AO. Methods A total 417 outpatients cardiometabolic diseases...
Aim We examined whether the Dementia Assessment Sheet for Community‐based Integrated Care System 8‐items (DASC‐8) is useful screening frailty and as a comprehensive geriatric assessment (CGA). Methods Outpatients ( N = 431; 269 women; M age 78.9 ± 6.8 years) with cardiometabolic disease from clinic participated. Frailty status was assessed using modified Cardiovascular Health Study criteria, Clinical Scale Kihon Checklist. Cognition, higher‐level activities of daily living, sarcopenia,...
Abstract Identification of low-abundance, low-molecular-weight native peptides using non-tryptic plasma has long remained an unmet challenge, leaving potential bioactive/biomarker undiscovered. We have succeeded in efficiently removing high-abundance proteins to enrich and comprehensively identify mass spectrometry. Native peptide sequences were chemically synthesized subsequent functional analyses resulted the discovery three novel bioactive polypeptides derived from epidermal...
Although vaccination against coronavirus disease (COVID-19) has several side effects, hypopituitarism due to hypophysitis rarely been reported.
Destructive thyroiditis and secondary adrenal insufficiency are major endocrinological immune-related adverse events of immune checkpoint inhibitors (ICIs). However, the timing at which each event occurs most frequently after drug administration varies, cases where multiple occur simultaneously rare. We encountered a patient who concurrently suffered from thyrotoxicosis insufficiency. An 80-year-old woman with history type 2 diabetes mellitus (DM) was diagnosed stage IVA squamous cell...
White matter abnormalities may reflect cerebral microvessel disease. Diffusion tensor imaging (DTI) can help detect early changes in white integrity each tract. However, studies investigating the relationship between subclinical atherosclerosis markers and alterations DTI findings are limited. This study aimed to examine associations cardiovascular risk factors indices of atherosclerosis—ankle brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), carotid artery intima-media...
Older adults with diabetes mellitus are susceptible to sarcopenia. Diffusion tensor imaging studies have also shown that patients altered white matter integrity. However, the relationship between these structural changes in and sarcopenia remains poorly understood.The study included 284 older (aged ≥65 years) who visited Tokyo Metropolitan Geriatric Hospital Frailty Clinic. We used diffusion measure fractional anisotropy (FA) mean diffusivity (MD) evaluate investigated associations...
Diffusion tensor imaging (DTI) can be used for the early detection of abnormal changes in integrity cerebral white matter tracts, and we have previously reported that these are associated with indices atherosclerotic lesions. Although been demonstrated to incidence frailty older adults, no studies investigated this relationship patients at high risk vascular disease. In longitudinal study, followed outpatients cardiometabolic diseases a maximum 6 years (median, 3 years) evaluated association...
Aim This longitudinal study aimed to determine whether categorization by the Dementia Assessment Sheet for Community‐based Integrated Care System 8‐items (DASC‐8) is associated with risk of frailty onset, disability, and mortality. Methods We analyzed data from outpatients aged 65 years older evaluated DASC‐8 at Frailty Clinic. The outcomes during 3‐year follow‐up period were (Study A) onset (Kihon Checklist ≥8) B) disability (new certification nursing care needs) or Multivariate Cox...
This observational longitudinal study aimed to explore the risk factors for disabilities in older Japanese individuals with diabetes at a frailty clinic, an outpatient clinic specializing comprehensive geriatric assessments patients.
The discovery of bioactive peptides is an important research target that enables the elucidation pathophysiology human diseases and provides seeds for drug discovery. Using a large number native previously identified using plasma peptidomics technology, we sequentially synthesized selected sequences subjected them to functional screening cultured cells. A 15-amino-acid residue proangiotensinogen-derived peptide, designated ANGT_HUMAN[448-462], elicited cellular responses bound Synthetic...
A 47-year-old woman with a history of diabetes mellitus (DM) and obesity was admitted to our hospital for glucose control. She detected have hypertension (HT) diagnosed primary aldosteronism (PA) based on the high level aldosterone renin ratio results upright furosemide-loading test according criteria Japanese Society Hypertension (JSH) guidelines. Computed tomography revealed left renal tumor adrenocortical adenoma. underwent nephrectomy adrenalectomy. The pathological findings were...