A5071473132- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Health Policy Implementation Science
- Health and Medical Research Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Electronic Health Records Systems
- Mental Health and Patient Involvement
- Social Media in Health Education
Colorado Clinical and Translational Sciences Institute
2023-2024
University of Colorado Anschutz Medical Campus
2020-2023
University of Colorado Denver
2018
Objectives/Goals: Electronic health record (EHR)-based recruitment can facilitate participation in clinical trials, but is not a panacea to trial accrual challenges. We conducted root cause analysis identify EHR-based barriers and facilitators pragmatic randomized of metformin for those with prostate cancer glucose intolerance. Methods/Study Population: quantitatively analyzed enrollment drop-offs among eligible patients who either did complete consent (with EHR-embedded process) or...
The ACT Network was funded by NIH to provide investigators from across the Clinical and Translational Science Award (CTSA) Consortium ability directly query national federated electronic health record (EHR) data for cohort discovery feasibility assessment of multi-site studies. refunded program expanded research application become "Evolve Next-Gen ACT" (ENACT). In parallel, US Food Drug Administration has been evaluating use real-world (RWD), including EHR data, as sources evidence (RWE) its...
The Clinical and Translational Science Award (CTSA) Program is a Consortium of nearly 60 academic medical research centers across the USA natural network for evaluating spread uptake translational innovation Consortium.Dissemination Accrual to Trials (ACT) Network, federated clinical informatics data population-based cohort discovery, began January 2018 Consortium. Diffusion theory guided dissemination design evaluation. Mixed-methods assessed through July 1, 2019 (n = 48 CTSAs). Methods...
Abstract Introduction: The expansion of electronic health record (EHR) data networks over the last two decades has significantly improved accessibility and processes around sharing. However, there lies a gap in meeting needs Clinical Translational Science Award (CTSA) hubs, particularly related to real-world (RWD) evidence (RWE). Methods: We adopted mixed-methods approach construct comprehensive assessment that included: (1) A Landscape Context analysis understand competitive environment;...
OBJECTIVES/SPECIFIC AIMS: The Clinical and Translational Science Award (CTSA) program is a national consortium of 50+ academic medical research centers charged with accelerating the translation clinical research. In 2017, NIH National Center for Advancing Sciences anticipates total CTSA funding over $500M. consortium’s hub-and-spoke structure makes it natural dissemination network, newest announcement innovation across an explicit goal, but characteristics hubs as adopters transmitters are...
Abstract BACKGROUND Engaging patients and care partners in research planning conduct improves equity patient-centeredness of research. Determining the most effective engagement methods remains challenging. This study evaluated participation experience using three with Low Grade Glioma (LGG) Registry’s OPTIMUM project, part Participant Engagement Cancer Genome Sequencing (PE-CGS) Network. METHODS We among participants LGG Registry Research Advisory Council (RAC) meetings, Twitter (“tweet...
Abstract BACKGROUND The International Low Grade Glioma (LGG) Registry is a community of people with LGGs who have contributed data and specimens to facilitate genomic research. aims discover the roles genetics environment play in glioma risk factors treatment response. To ensure findings apply range diverse populations settings, it crucial build trust encourage representative participation Registry. METHODS Three engagement strategies were used gather recommendations for improving LGG We...
OBJECTIVES/SPECIFIC AIMS: The ACT Network was developed by 46 members of the CTSA Program hubs in collaboration with NCATS to help investigators explore and validate feasibility clinical studies real-time using linked electronic health record data for cohort discovery. is being disseminated nationally across consortium. METHODS/STUDY POPULATION: Diffusion Innovation Theory Lean Start-Up principles inform dissemination strategies. Core materials were are tailored meet local norms. An advisory...