A5021407797- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Microbial infections and disease research
- Antimicrobial Resistance in Staphylococcus
- Pituitary Gland Disorders and Treatments
- Parasitic Diseases Research and Treatment
- Veterinary Medicine and Surgery
- Veterinary Oncology Research
- Hedgehog Signaling Pathway Studies
- Mycobacterium research and diagnosis
- Growth Hormone and Insulin-like Growth Factors
- Pharmaceutical and Antibiotic Environmental Impacts
Royal Veterinary College
2021-2025
This study examines the pharmacodynamics (PD) of florfenicol (FFN) for treating porcine respiratory diseases by comparing its effects on Glaesserella parasuis, Actinobacillus pleuropneumoniae and Pasteurella multocida. In vitro time-kill assays semi-mechanistic PD modeling were used to assess bacterial growth killing rates at varying FFN concentrations. Species-specific models indicated that fAUC/MIC was best PK/PD index across all species. A. P. multocida had target values 1.05 1.66 × MIC,...
Colistin, a last-line antibiotic of major importance in veterinary medicine and critical human medicine, is authorized to treat gastrointestinal (enteric) infections caused by non-invasive Escherichia coli multiple species including poultry. Its use has been implicated the widespread prevalence mobilized colistin resistance. The objectives this study were determine intestinal content reached broiler chickens during 72-h treatment with colistin, evaluate associated impact on E. density,...
Fluoroquinolones (FQ) are commonly used in dogs with bacterial skin infections. Their use as first choice, along the increased incidence of FQ-resistance, represents a risk to animal and public health. Our study determined minimum inhibitory (MIC) bactericidal (MBC) concentrations five FQs Staphylococcus aureus, pseudintermedius, Escherichia coli, together FQ-resistance mechanisms. MICs, efflux pump (EP) overexpression MBCs were measured 249 infection isolates following CLSI guidelines (CLSI...
Electrolyte abnormalities, especially hypernatremia, are frequent complications after transsphenoidal hypophysectomy in dogs with pituitary-dependent hypercortisolism.To describe electrolyte abnormalities and to investigate possible associations between postoperative hypernatremia clinical surgical variables as well outcome.One hundred twenty-seven client-owned dogs.Dogs pituitary corticotroph adenomas that underwent were retrospectively included. Plasma sodium potassium concentrations...
The Hollow-fibre Infection Model (HFIM) is a valuable in vitro platform for emulating antimicrobial drug (AMD) pharmacokinetic (PK) profiles. Despite its potential, standardized protocols HFIM operation, especially concerning fastidious organisms, are lacking. This study addresses this gap by examining challenges culturing Pasteurella multocida and Actinobacillus pleuropneumoniae, two the HFIM. Our findings reveal effective strategies to prevent system clogging, involving multiple...
The hollow-fibre infection model (HFIM) is a valuable in vitro platform for emulating antimicrobial drug pharmacokinetic profiles. Despite its potential, standardized protocols HFIM operation, especially concerning fastidious organisms, are lacking. This study addresses this gap by examining challenges culturing Pasteurella multocida and Actinobacillus pleuropneumoniae , two the HFIM. Our findings reveal effective strategies to prevent system clogging, involving multiple freeze–thaw cycles...
Time-kill curves (TKCs) are more informative compared with the use of minimum inhibitory concentration (MIC) as they allow capture bacterial growth and development drug killing rates over time, which allows to compute key pharmacodynamic (PD) parameters. Our study aimed, using a semi-mechanistic mathematical model, estimate best pharmacokinetic/pharmacodynamic (PK/PD) indices (ƒAUC/MIC or %ƒT > MIC) for prediction clinical efficacy veterinary FQs in Staphylococcus pseudintermedius, aureus,...
The Hollow-fibre Infection Model (HFIM) is a valuable in vitro platform for emulating antimicrobial drug (AMD) pharmacokinetic (PK) profiles. Despite its potential, standardized protocols HFIM operation, especially concerning fastidious organisms, are lacking. This study addresses this gap by examining challenges culturing Pasteurella multocida and Actinobacillus pleuropneumoniae, two the HFIM. Our findings reveal effective strategies to prevent system clogging, involving multiple...