A5027980745- Herpesvirus Infections and Treatments
- Poxvirus research and outbreaks
- SARS-CoV-2 and COVID-19 Research
- Bacillus and Francisella bacterial research
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Quinazolinone synthesis and applications
- Microbial Natural Products and Biosynthesis
- Long-Term Effects of COVID-19
- Advanced Synthetic Organic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Microplastics and Plastic Pollution
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical synthesis and alkaloids
University of Washington
2022-2025
University of Washington Tacoma
2021-2024
Recently, roadway releases of
Interest in therapeutic discovery typically drives the preparation of natural product analogs, but these undertakings contribute significant advances for synthetic chemistry as well. The need a highly efficient and scalable route to complex molecular scaffold diversification frequently inspires new methodological development or unique application existing methods on structurally intricate systems. Additionally, planning with an aim toward late-stage can provide access otherwise unavailable...
People living with HIV (PLWH) have an increased risk of severe COVID-19, including prolonged viral shedding and emergence mutations. To investigate the simian immunodeficiency virus (SIV) macaque model for HIV/SARS-CoV-2 co-infection, seven SIV+ rhesus macaques were co-infected SARS-CoV-2. COVID-19 in all was mild. SARS-CoV-2 replication persisted upper, but not lower respiratory tract 14 days post-infection. Animals showed impaired generation anti-SARS-CoV-2 antibodies T-cells. also...
The synthesis of a biologically relevant 2-amino-
Abstract BACKGROUND In spring of 2022, an outbreak monkeypox spread worldwide. Here, we describe performance characteristics virus (MPXV)-specific and pan-orthopoxvirus qPCR assays for clinical use. METHODS We validated probe-based targeting MPXV-specific loci F3L G2R (genes MPXVgp052/OPG065 MPXVgp002 gp190/OPG002, respectively) a assay the E9L locus (MPXVgp057/OPG071). Clinical samples synthetic controls were extracted using Roche MP96 or Promega Maxwell 48 instrument. was performed on...