Catalytic hydrotreatment is an attractive technology to convert fast pyrolysis oil stabilized products for co-processing in conventional crude refinery units. We report here the use of novel bimetallic NiCu- and NiPd-based (Picula) catalysts characterized by a high Ni content (29–58 wt %) prepared using sol–gel method with SiO2, La2O3, kaolin, ZrO2, combinations thereof as support, catalytic oil. The experiments were performed batch autoclave (1 h at 150 °C, 3 350 200 bar initial pressure...

In this paper, the effects of process conditions on catalyst performance and product properties are reported in both batch continuous set-ups.

CD44 is a hyaluronic acid receptor, surface molecule expressed on many cells in human body that essential for some processes, such as cell adhesion and migration. Therefore, this also plays an important role various aspects of tumor growth, metastasis invasive processes. High levels expression have been found from patients with hematological malignancies, there direct link between the likelihood relapse, well dismal prognosis most malignancies. The purpose study was to determine level cells,...

Background. Cd44 molecule is overexpressed on tumor‑associated cells, including stem in the tumor microenvironment, which most cases a poor prognostic marker for progression. In addition, pd‑L1 positively correlates with Cd44, associated resistance to antitumor therapy, so these markers are perspective targets both diagnostics and therapy of oncological diseases. Aim. To determine expression checkpoint molecules during co‑cultivation hematopoietic cells under various conditions. Materials...

Abstract Catalytic hydrotreatment is a promising technology to convert pyrolysis liquids into intermediates with improved properties. Here, we report catalyst screening study on the catalytic of using bi- and tri-metallic nickel-based catalysts in batch autoclave (initial hydrogen pressure 140 bar, 350 °C, 4 h). The are characterized by high nickel metal loading (41 57 wt%), promoted Cu, Pd, Mo, and/or combination thereof, SiO 2 , -ZrO or -Al O 3 matrix. results were compared benchmark Ru/C...

Cucurbiturils are a family of macrocyclic oligomers capable forming host–guest complexes with various molecules. Due to noncovalent binding drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carriers for delivery. However, the immune system’s interactions different carriers, including cucurbiturils, still under investigation. In this study, we focused on cucurbiturils’ immunosafety immunomodulation properties in vivo. We measured blood counts...

Abstract The cellular uptake of drug carriers to the cytosol a specific cell remains challenging, and non‐classical supramolecular strategy is motivated. Here, we select model host–guest complex in which diamino‐viologen (1,1′‐bis(4‐aminophenyl)‐[4,4′‐bipyridine]−1,1′‐diium dichloride [VG]) fluorescent tag was engulfed by cucurbit[8]uril (CB8) covalently linked alginate polysaccharides (alginic acid [ALG]) as modified vehicle. When adsorbed on ALG surface, encapsulation VG first confirmed...

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but eliminating the cause disease, is allergen-specific immunotherapy (AIT). To reduce risk side effects and improve delivery allergens to mucosa, various systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. date, there are data on creation systems based glycyrrhizic acid (GA) its derivatives, a system has been used for therapy until now. It also known that GA an anti-inflammatory...

Tumors are a leading pathology in the population. Chemotherapy cannot provide adequately and effectively to cure patients. Some medicine, such as cytostatic, characterized by wide range of side effects resistance solid tumors chemotherapy these medicines. In recent research, mechanisms action cytotoxic agents have been described, most appropriate causes suggested. Drug delivery system based on Cucurbit[7]uril (CB[7]) was used minimize overcome resistance. CB[7] has ability form host-guest...

. Cucurbiturils are a family of macrocyclic oligomers capable forming host-guest complexes with various molecules. Due to noncovalent binding drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carrier for delivery. However, the immune system interactions different carriers, including cucurbiturils, still under investigation. In this study, we focused on immunosafety immunomodulation properties in vivo. We measured blood counts, lymphocyte...

One of the modern approaches to treatment cancer is creation targeted delivery systems for anticancer drugs, which allows increasing concentration delivered substance in right place and preventing its accumulation healthy organs tissues. At same time, one can also expect an increase duration effectiveness as well a reduction side effects during therapy. The hyaluronic acid receptor CD44, which, according literature, highly expressed many types tumors regulates metastasis, promising target...

In recent years, hyaluronic acid (HA) has attracted increasing attention as a promising biomaterial for the development of drug delivery systems. Due to its unique properties, such high biocompatibility, low toxicity, and modifiability, HA is becoming basis creation targeted systems, especially in field oncology. Receptors overexpressed subpopulations cancer cells one them, CD44, recognized molecular marker stem cells. This review examines role receptors health tumors analyzes existing...

Today, there is a theory that proliferative potential of hematopoietic stem cells depleted, and the balance committed precursor shifts towards suppressors during development cancer. However, differentiation can vary depending on tumor type, localization, microenvironment specifics. The study aimed to assess impact tumors various origins CD34+ (n = 10). Assessment cell cycle via both direct contact with exchanging humoral factors only in transwells was conducted by flow cytometry. In...

There has been a recent increase in the incidence of allergies and severity allergic reactions worldwide. Most allergy treatments, such as antihistamines, only treat symptoms allergy. In contrast, allergen-specific immunotherapy (ASIT) refers to pathogenetic treatment that prevents progression allergies. ASIT can also reduce risk mild reactions, rhinitis, worsening into more serious conditions, bronchial asthma. is performed by administration an allergen, usually either subcutaneously or...

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but eliminating the cause disease, is allergen-specific immunotherapy (AIT). To reduce risk side effects and improve delivery allergens to mucosa, various systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. date, there are data on creation systems based glycyrrhizic acid (GA) its derivatives, a system has been used for therapy until now. At same time, it known that GA an...