A5020793004- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Supramolecular Chemistry and Complexes
- RNA Interference and Gene Delivery
- Human Health and Disease
- Lipid Membrane Structure and Behavior
- Cell death mechanisms and regulation
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Hydrogen's biological and therapeutic effects
- Immune Response and Inflammation
- Effects of Radiation Exposure
- Cytomegalovirus and herpesvirus research
- Glycosylation and Glycoproteins Research
- Asthma and respiratory diseases
- Healthcare Systems and Public Health
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- High Altitude and Hypoxia
- Medical and Biological Ozone Research
- Mass Spectrometry Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Medical and Agricultural Research Studies
- Atherosclerosis and Cardiovascular Diseases
Research Institute of Fundamental and Clinical Immunology
2019-2024
Academy of Medical Sciences
2007
Cucurbiturils are a family of macrocyclic oligomers capable forming host–guest complexes with various molecules. Due to noncovalent binding drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carriers for delivery. However, the immune system’s interactions different carriers, including cucurbiturils, still under investigation. In this study, we focused on cucurbiturils’ immunosafety immunomodulation properties in vivo. We measured blood counts...
Currently, cucurbiturils are being actively researched all over the world. Research is focused on ways of improving solubility and selectivity cucurbiturils, increasing stability complexes with other particles in various media enhancing their ability to bind release substances. The most significant area our research assessment safety, studying biological properties synergistic effects during complexation drugs. In this article, hemocompatibility erythrocytes leukocytes was investigated. We...
Tumors are a leading pathology in the population. Chemotherapy cannot provide adequately and effectively to cure patients. Some medicine, such as cytostatic, characterized by wide range of side effects resistance solid tumors chemotherapy these medicines. In recent research, mechanisms action cytotoxic agents have been described, most appropriate causes suggested. Drug delivery system based on Cucurbit[7]uril (CB[7]) was used minimize overcome resistance. CB[7] has ability form host-guest...
. Cucurbiturils are a family of macrocyclic oligomers capable forming host-guest complexes with various molecules. Due to noncovalent binding drug molecules and low toxicity, cucurbiturils has been extensively investigated as potential carrier for delivery. However, the immune system interactions different carriers, including cucurbiturils, still under investigation. In this study, we focused on immunosafety immunomodulation properties in vivo. We measured blood counts, lymphocyte...
Bronchial asthma is a chronic inflammatory disease of the respiratory tract. T-lymphocytes play key role in pathogenesis this allergic disease. The reduction number naïve T cells and accumulation memory bronchial are accompanied by dysregulation lymphocyte function. In present study, we have investigated contents different subpopulations peripheral blood as well resting PHA-stimulated cultures, along with their proliferative capacity patients healthy donors. study included 10 (age 45.4±11.8...
The process of apoptosis is known that play an important role in cellular homeostasis, and the altered cell death may lead to development pathological disorders. Evolving autoimmune conditions, particular, rheumatoid arthritis, are associated with decreased rates as a form programmed death. aim this study was evaluate expression activation proliferation markers on T lymphocytes during initiation apoptotic under conditions “cell neighborhood” healthy individuals patients arthritis. Patients...
Cellular homeostasis in the body is known to be maintained by processes of cell proliferation and death, whereas apoptosis most frequent physiological, “silent” mechanism elimination. It has been currently shown that process traditionally considered an autonomous event, a pronounced non-autonomous effect on migration, proliferation, death neighboring cells. This work was based data impaired programmed mononuclear cells from patients with rheumatoid arthritis (RA) leading evolving autoimmune...
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease, the development of which associated with impaired mechanisms cell number control, proliferation balance, and apoptosis. The aim our study was to perform comprehensive analysis cellular humoral effects exerted by “apoptotic” T lymphocyte culture upon “proliferating” cells, taking into account parameters “primary” “secondary” apoptosis induction, activation markers, viable contents, role cortisol, caspase...
Much attention of researchers is directed to study the role factors homeostatic proliferation in pathogenesis autoimmune diseases, however, effect IL-7 and IL-15 on phenotype naive T cells has not yet been sufficiently investigated pathology. The aim this was investigate proportion CD45RA + CD31 among CD4 CD8 lymphocytes from healthy individuals patients with rheumatoid arthritis (RA) upon stimulation IL-7, vitro. In peripheral blood, we did find any differences number between group donors...