A5075739188- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Response and Inflammation
- Erythrocyte Function and Pathophysiology
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- RNA Research and Splicing
- Microbial Inactivation Methods
- Rheumatoid Arthritis Research and Therapies
- Atherosclerosis and Cardiovascular Diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Transgenic Plants and Applications
- Toxin Mechanisms and Immunotoxins
- Cancer Immunotherapy and Biomarkers
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Melanoma and MAPK Pathways
- Inflammasome and immune disorders
- Genomics, phytochemicals, and oxidative stress
- 3D Printing in Biomedical Research
- Exercise and Physiological Responses
- Biomarkers in Disease Mechanisms
- RNA modifications and cancer
Research Institute of Fundamental and Clinical Immunology
2004-2024
Russian Academy of Sciences
2006-2012
Academy of Medical Sciences
2007-2012
Institute of Immunology
2012
Minimal residual disease remaining after resection of primary tumors can lead to tumor recurrence and metastasis, increasing mortality morbidity rates among cancer patients. Thus, there is a need for new technologies recognition elimination single cells in patient's body radiation therapy, chemotherapy, or surgical resection. Effector CD8+ T cells, also commonly known as cytotoxic lymphocytes (CTLs), play key role antitumor cellular immunity and, when properly activated, are able effectively...
Abstract Background Erythroid nuclear cells (ENC) of the bone marrow (BM) have not previously been considered as important producers wide spectrum haemo- and immunoregulatory cytokines. The aim current work was to confirm production main hemo- cytokines in human ENC from BM. Results We used native BM our experiments. for first time shown, that unstimulated erythroblasts (Gl A + or AG-EB ) produced a Human produce such interleukn (IL)-1β, IL-2, IL-4, IL-6, interferon (IFN)-γ, transforming...
The level of TNF receptors on various cells immune system and its association with the gene polymorphism were investigated. Determining levels membrane-bound α peripheral blood mononuclear (PBMCs) was performed by flow cytometry using BD QuantiBRITE calibration particles. Soluble receptor (sTNFRs) determined ELISA genotyping PCR-RFLP. Homozygous TT individuals at SNP<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mo>-</mml:mo><mml:mn>609</mml:mn></mml:math>G/T TNFRI...
TCR-like chimeric antigen receptor (CAR-T) cell therapy has emerged as a game-changing strategy in cancer immunotherapy, offering broad spectrum of potential targets, particularly solid tumors containing intracellular antigens. In this study, we investigated the cytotoxicity and functional attributes vitro-generated T-lymphocytes, engineered with CAR precisely targeting testis MAGE-A4. Through viral transduction, T-cells were genetically modified to express co-cultured MAGE-A4-expressing...
Adoptive T-cell therapies tailored for the treatment of solid tumors encounter intricate challenges, necessitating meticulous selection specific target antigens and engineering highly receptors (TCRs). This study delves into cytotoxicity functional characteristics in vitro-cultured T-lymphocytes, equipped with a TCR designed to precisely cancer-testis antigen NY-ESO-1. Flow cytometry analysis unveiled notable increase population cells expressing activation markers upon encountering...
Introduction Adoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested a variety blood neoplasms but yet to be deeply solid tumors. Among tumors, cancer-testis antigens are prominent targets for tumor-specific therapy, as they usually found on cells that lie behind blood-tissue barriers. Methods We have employed novel efficient protocol MAGE-A3-specific clonal expansion, performed single-cell...
The development of T cell receptor-engineered cells (TCR-T) targeting intracellular antigens is a promising strategy for treating solid tumors; however, the mechanisms underlying their effectiveness remain poorly understood. In this study, we employed advanced techniques to investigate functional state engineered with retroviral vectors express TCR specific NY-ESO-1 157-165 peptide in HLA-A*02:01 context. Flow cytometry revealed predominance naïve cells. Gene expression profiling using...
: Adoptive cell therapy is the most promising approach for battling cancer, with T receptor-engineered (TCR-T) emerging as viable option treating solid tumors. Current techniques preparing TCR-T provide a limited number of candidates TCRs, missing comprehensive view repertoire, which may hinder identification effective TCRs.
Adoptive cell therapy, particularly T receptor–engineered (TCR-T) represents a cutting-edge and promising strategy for treating solid tumors [1]. Current methods developing TCR-T therapies yield limited number of candidate TCRs [2], missing the comprehensive view repertoire, which may impede identification most effective TCRs. This limitation highlights need new techniques in therapy development.
TCR-engineered T cells targeting intracellular antigens hold promise for cancer therapy. Yet, the mechanisms driving their effectiveness remain elusive. This study employed a cutting-edge approach to explore adaptation and functional state of with TCR specific NY-ESO-1 in vivo. We revealed unique subset CD8+ effector cells, exhibiting gene expression profile characteristic both CTLs NK cells.
In this study antigen-specific T cells expressing chimeric antigen receptor (CAR) targeting disialoganglioside (GD2) and GITR ligand were generated using retroviral transduction. The GD2-specific CAR exhibited antitumor activity properties in vitro vivo against GD2+ tumor cell lines.
Background . Nonspecific immunosuppressive therapy for graft rejection and graft-versus-host disease (GVHD) is often accompanied by severe side effects such as opportunistic infections cancers. Several approaches have been developed to suppress transplantation reactions using tolerogenic cells, including induction of FoxP3 + Tregs with antigen-loaded dendritic cells (DCs) CD4 IL-10 interleukin IL-10-producing DCs. Here, we assessed the effectiveness both in suppression GVHD. Methods DCs were...
Search for molecular genetic markers of risk and prognosis breast cancer is an important prospective modern research. Many mechanisms are involved in pathogenesis define a wide range possible candidate genes. The genes pro-inflammatory cytokine receptors, such as tumor necrosis factor interleukin-1, also among potential Numerous functional allelic variants these have been shown which associated with changed expression membranebound soluble forms the receptors. In addition, they expressed...