Non-small cell lung cancer (NSCLC) is a worldwide health threat with high annual morbidity and mortality. Chemotherapeutic drugs such as paclitaxel (PTX) have been widely applied clinically. However, systemic toxicity due to the non-specific circulation of PTX often leads multi-organ damage, including liver kidney. Thus, it necessary develop novel strategy enhance targeted antitumor effects PTX.Here, we engineered exosomes derived from T cells expressing chimeric antigen receptor (CAR-Exos),...

In this study, molecular dynamics simulations were used to investigate the micro-scale effects of modification nano-SiO2 with commonly silane coupling agents (KH550, KH560, KH570, and KH792) on cellulose/nano-SiO2 interface. The relative optimum agent grafting density for improve interface determined. results showed that at same density, KH792 yielded highest interfacial binding energy largest number hydrogen bonds interface, strongest cellulose chains, overlapping area We found non-bonding...

The development of new materials for use in advanced distribution transformers is required to improve their heat resistance rating, operational safety, and reliability. combination polymer nanoparticles the preferred approach thermal stability materials. In this study, laboratory-prepared meta-aramid insulation paper modified with polyphenylsilsesquioxane (PPSQ) was evaluated. results showed that superior unmodified paper. Molecular dynamics simulations were used analyse internal mechanism...

Calpain small subunit 1 (Capn4) plays a key role in tumor migration or invasion. In this study, expression and function of Capn4 was investigated human nasopharyngeal carcinoma ( NPC) . Here we report that both mRNA protein levels were elevated NPC tissues when compared to normal NP tissues. Similarly, also highly expressed multiple cell lines, immortalized epithelial line 69. Moreover, significantly correlated with Epstein‐Barr virus infection, advanced stages, lymph node distant metastasis...

Thermodynamic properties of cellulose insulation paper are vital factors affecting the life a transformer; in order to obtain with better thermodynamic properties, three types silane coupling agents—3-aminopropyltriethoxy (KH550), 3-glycidoxypropyltrimethoxy (KH560), and 3-methacryloyloxypropyltrimethoxy (KH570)—were grafted on surface nano-SiO2, modified nano-SiO2 were explored. The molecular dynamics method was used establish composite model nano-SiO2/cellulose. Also, different agent...

The synergistic application of magnetic fields and iron oxide nanorod particles (IONPs) presents a novel therapeutic approach for inducing lysosome-dependent cell death (LDCL) via magneto-mechanical force (MMF). This study demonstrates the efficacy decaying oscillating pulsed (DOPMFs) to propel IONPs induce rapid tumor regression lysosomal membrane permeabilization (LMP). systematic evaluation dose-dependent parameters revealed that DOPMF intensity pulse number critically determine A375...

Non-contact pulsed magnetic fields can enhance the permeability of biological cells, creating an innovative approach for delivering external substances through cell membranes. However, mechanism by which cause permeabilization remains unclear, and experimental findings from different researchers often vary widely, sometimes even contradicting one another. To gain a deeper understanding caused fields, this study uses theoretical analytical approach. It begins with qualitative analysis how...

Abstract Amyotrophic lateral sclerosis is characterized by the progressive loss of motor neurons. Early-stage axonal dysfunction, rather than central nervous system injury, plays a key role in disease process. However, molecular mechanisms underlying this dysfunction remain unclear. To investigate relationship between peripheral immune dysregulation and amyotrophic sclerosis, we recruited 372 patients within first 12 months sporadic onset January 2018 May 2024. We collected markers at...

This paper presents the results of a laboratory investigation influence zone (IZ) air sparging (AS) in different media at surface tension. Different kinds were used two-dimensional tank experiments, designed to determine (1) effect tension reduction on airflow pattern during AS travelling modes (channels and bubbles) homogeneous aquifer (2) distribution migration characteristics heterogeneous AS. The demonstrated that gravel aquifer, IZ was almost identical with or without surfactant...

Pulsed electric field-induced electroporation has been widely used, but its specific perforation theory not fully elucidated. Therefore, this Perspective paper takes as a clue the dynamic development relationship between pore energy and state in cell membranes. First, based on contribution of line tension, surface steric repulsion, applied field to energy, theoretical models reversible microsecond pulsed irreversible high-frequency nanosecond are reviewed. Then, elastic strain is increased,...

The mechanical properties of the cell membrane play an important role in electroporation. This paper studied influence on transition energy electroporation through both modeling and experiments. An electromechanical coupling model a single pore was established COMSOL, effect elastic strain formation pores analyzed. Additionally, to compare barrier for different membrane, experiments were carried out at temperatures. simulation showed that increased pores. also larger when elasticity is...

Polymethylsilsesquioxane (PMSQ) nanoparticles with mass percentages of 0, 2.5, 5.0, 7.2, 9.4 wt %, respectively, were constructed by molecular dynamics methods in this paper. Composite models established using PMSQ and MPIA (poly-metaphenylene isophthalamide) fiber. The influence different contents on the thermal stability meta-aramid insulation paper was analyzed from parameters mechanical property, interaction energy, mean square displacement. results showed that trend properties decreased...

The combination of magnetic fields and nanoparticles (MNPs) to kill cancer cells by magneto-mechanical force represents a novel therapy, offering advantages such as non-invasiveness, among others. Pulsed (PMFs) hold promise for application in this therapy due easily adjustable parameters; however, they suffer from the drawback narrow pulse width. In order fully exploit potential PMFs MNPs while maximizing therapeutic efficacy within constraints width, feature-matching theory is proposed,...

In this work, prochloraz pH-responsive nanocapsules were developed by the Pickering emulsion polymerization method with isophorone diisocyanate (IPDI) as reaction monomer and nano Fe3O4 particle-branched polyethyleneimine (PEI) surfactant. The physical chemical properties sustained release determined a transmission electron microscope (TEM), field emission (FETEM), atomic force (AFM), laser particle size analyzer, Fourier transform infrared spectrometer, contact angle tester. results...

Overexpression of aquaporin protein 5 (AQP5) is associated with the metastasis, migration and angiogenesis ovarian cancer, but its function in cell proliferation has not been described. This study was to explore effects topotecan (TPT) on expression AQP5, nuclear factor-kappaB (NF-kappaB) receptor IkappaBalpha cancer SKOV3 cells.When cells were treated TPT various concentrations for different time, measured by MTT assay, NF-kappaB detected Western blot.After incubated 0.4 microg/mL 24 h, p65...

In previous studies, PCAT1 has been proved to be a key carcinogenic driver in hepatocellular carcinoma. However, the regulatory mechanism of remains poorly understood diffuse large B-cell lymphoma (DLBCL).The expression PCAT1, miR-508-3p and NFIB DLBCL was detected by RT-qPCR assay. CCK-8 assay transwell were used measure cell proliferation, migration invasion cells. Western blot explore protein NFIB. Dual-Luciferase reporter applied correlation between NFIB.PCAT1 demonstrated upregulated...

Poor efficacy and low electrical safety are issues in the treatment of tumours with pulsed magnetic fields (PMFs). Based on cumulative effect high-frequency pulses enhanced perforation targeted nanoparticles, this article proposes for first time a new method that combines nanosecond-pulsed (nsPMFs) folic acid-superparamagnetic iron oxide nanoparticles (SPIONs-FA) to kill tumour cells. After determining safe concentration CCK-8 reagent was used detect changes cell viability after utilising...

Background: Rabdosia japonica has been historically used in China as a popular folk medicine for the treatment of cancer, hepatitis, and gastricism. Glaucocalyxin A (GLA), an ent-kaurene diterpene isolated from japonica, is one main active ingredients showing potent inhibitory effects against several types tumor cells. To best our knowledge, studies regarding structural modification Structure- Activity Relations (SAR) this compound have not yet reported. Objective: The aim study was to...

Pulsed magnetic field treatment can enhance cell membrane permeability, allowing large molecular substances that normally cannot pass through the to enter cell. This research holds significant prospects for biomedical applications. However, mechanism underlying pulsed field-induced permeabilization remains unclear, impeding further progress in related field. Currently, hypotheses about are struggling explain experimental results. Therefore, this study developed a parameter-adjustable...

The spatial resolution (250–1000 m) of the FY-3D MERSI is too coarse for agricultural monitoring at farmland scale (20–30 m). To achieve winter wheat yield (WWY) scale, based on FY-3D, a method framework developed in this work. enhanced deep convolutional spatiotemporal fusion network (EDCSTFN) was used to perform 10 day interval and Sentinel-2 vegetation indices (VIs), which were compared with temporal adaptive reflectance model (ESTARFM). In addition, BP neural built calculate...