A5102990637- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Calpain Protease Function and Regulation
- Ubiquitin and proteasome pathways
- Dental materials and restorations
- DNA Repair Mechanisms
- interferon and immune responses
- Dental Research and COVID-19
- Reproductive Biology and Fertility
- Cellular transport and secretion
- Atherosclerosis and Cardiovascular Diseases
- Cancer therapeutics and mechanisms
- Photosynthetic Processes and Mechanisms
- Signaling Pathways in Disease
- Asthma and respiratory diseases
- Magnetism in coordination complexes
- Anatomy and Medical Technology
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- PARP inhibition in cancer therapy
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
- NF-κB Signaling Pathways
- Nuclear Structure and Function
Fujian Medical University
2014-2025
Southeast University
2012-2013
Calpain small subunit 1 (Capn4) plays a key role in tumor migration or invasion. In this study, expression and function of Capn4 was investigated human nasopharyngeal carcinoma ( NPC) . Here we report that both mRNA protein levels were elevated NPC tissues when compared to normal NP tissues. Similarly, also highly expressed multiple cell lines, immortalized epithelial line 69. Moreover, significantly correlated with Epstein‐Barr virus infection, advanced stages, lymph node distant metastasis...
TSLP regulates eotaxin-1 production by nasal epithelial cells from patients with
Abstract Capn4, also known as CapnS1, is a member of the calpain family, which plays crucial role in maintaining activity and function calpain. We previously reported that Capn4 an essential migration nasopharyngeal carcinoma (NPC) cells through regulation (MMP‐2) by nuclear factor‐kappa B activation. Epstein‐Barr virus latent membrane protein 1 (LMP1) closely related to malignant functions NPC; however, relationship between LMP1 NPC remain unclear. Immunohistochemical studies showed level...
<b><i>Aim:</i></b> To investigate the expression and clinical significance of ATP-binding cassette transporter 1 (ABCA1) in pregnant women with preeclampsia (PE). <b><i>Methods:</i></b> 52 PE who were admitted for delivery enrolled study, while 30 normal inpatients chosen as controls. Blood lipid serum ABCA1 concentrations assayed by enzymatic analysis ELISA, respectively, <i>ABCA1</i> gene its encoded protein detected quantified...
To synthesize and determine the antifungal activity of AgBr-nanoparticles (NP) @CTMAB (cetyltrimethyl-ammonium bromide) against Candida albicans (C. albicans) for use in field denture cleaning.The morphology structure AgBr-NP@CTMAB were characterized by IR, UV-Vis, XRD SEM. The potential C. was determined colony formation assay growth curve analysis. PMMA containing prepared, long-term efficacy analyzed. effect biofilm analyzed SEM OD600 , color changes specimens observed stereomicroscopy...
Chronic prenatal hypoxia is a damaging to fetal development and may have various consequences, including hearing loss. Connexin 26 (Cx26) one of the major protein subunits required for gap junction formation, has an important role in maintaining homeostasis cochlea normal hearing. Cx26 mutation expression abnormality are closely associated with inherited nonsyndromic deafness, but association between less established. The present study aimed examine aberrant methylation promoter region from...
Determining whether tea extracts are effective in removing Candida albicans (C. albicans) from dentures is of interest. This study aimed to investigate the antifungal effect on C. albicans. One green (Anji white tea, AGW) and 2 oolong teas (Tie Guan Yin, TGY; Da Hong Pao, DHP) different concentrations were tested. suspensions inoculated plates numbers colony-forming units (CFU) culture medium used screen for optimum extracts. Polymethyl methacrylate (PMMA) specimens that contained biofilms...
Nine novel 4‐aminoquinazoline derivatives were designed and synthesized. Biochemical cellular analyses demonstrated that most of the exhibited a strong activity to inhibit Aurora A B kinases suppress proliferation panel human tumor cell lines (U937, K562, A549, LoVo, HT29). Quantum chemical studies also carried out determine structural features these compounds engaged in inhibition kinases.
Purpose: To investigate the inhibition of Streptococcus mutans (S.mutans) and its biofilm by AgBr-nanoparticles (NP) @CTMAB (cetyltrimethyl-ammonium bromide) evaluate changes in Polymethyl methacrylate (PMMA)’s surface roughness (Ra), microhardness, flexural strength during prolonged immersion AgBr-NP@CTMAB for application denture cleaning industry. Patients Methods: The antibacterial activity against S.mutans was measured colony formation assay, OD600 laser confocal microscopy. Changes...
Etoposide (VP-16) is used for the treatment of various cancers, including nasopharyngeal carcinoma (NPC); however, cancers develop resistance to this agent by promoting DNA repair. The DNA-PK (DNA-PKcs) catalytic subunit and poly(ADP-ribose) polymerase 1 (PARP1) mediate acquired poor survival in NPC cells exposed damaging agents. repair can alter sensitivity agents, these two enzymes function concomitantly response damage vivo. Therefore, we explored relationship between DNA-PKcs PARP1,...
The metastasis and recurrence of nasopharyngeal carcinoma (NPC) contribute to the poor prognosis patients. Inhibiting epithelial-mesenchymal transition (EMT) is an effective strategy obstruct metastasis. Therefore, this study aimed explore effects Capn4 on EMT NPC cells its specific mechanism action. mRNA protein expression levels objective genes in cell lines (5-8F CNE-2) were evaluated by qRT-PCR western blotting methods. subcellular localization was detected immunofluorescence (IF)....
Abstract Preclinical Research The A urora family of serine/threonine kinases plays important roles in process cell division or mitosis. Overexpression , B and C has been identified many human cancers including colon carcinoma cells. To date, a number small molecular inhibitors have developed for reducing activities tumor cells preclinical clinical trials. In this study, we describe the properties AM ‐005, novel orally active / kinase inhibitor. ‐005 irreversibly inhibited proliferation...
Abstract The goal of the study reported here was to determine developmental potential cloned embryos using two donor cells [fetal‐derived fibroblast (FFCs) and adult‐derived (AFCs)] in vitro fertilization (IVF) with oocytes obtained by ovum pickup (OPU) relationship between timing first cleavage pregnancy or calving rate. Heifers were subjected OPU once weekly. In total, 1558 recovered from 2033 follicles, a mean 7.8±0.4 per session animal. Mean oocyte production similar not quantity but...
Scientific education is an important part of modern medical education,including four aspects(scientific knowledge,scientific method,scientific attitude and scientific spirit)which war out balance in hnman anatomy teaching.Four aspects should be balanced teaching,which may mainly accomplished through changing the idea teachers,permeating teaching with opening extra-curricular classes. Key words: Human anatomy; Scientific education; Teaching