A5103158479- Mycotoxins in Agriculture and Food
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Viral Infectious Diseases and Gene Expression in Insects
- Pesticide and Herbicide Environmental Studies
- Glutathione Transferases and Polymorphisms
- Renal Transplantation Outcomes and Treatments
- Radiation Effects and Dosimetry
- Pharmaceutical and Antibiotic Environmental Impacts
- Effects and risks of endocrine disrupting chemicals
- Pharmacogenetics and Drug Metabolism
University of Padua
2022-2024
Poly- and perfluoroalkyl substances (PFAS) are frequently detected in the environment linked to adverse reproductive health outcomes humans. Although legacy PFAS have been phased out due their toxicity, alternative increasingly used despite fact that information on toxic effects traits is particularly scarce. Here, we exposed male guppies (Poecilia reticulata) for a short period (21 days) an environmentally realistic concentration (1 ppb) of PFOA, PFAS, its replacement compound, GenX, assess...
Aflatoxin B1 (AFB1) is a food contaminant metabolized mostly in the liver and leading to hepatic damage. Livestock species are differently susceptible AFB1, but underlying mechanisms of toxicity have not yet been fully investigated, especially ruminants. Thus, aim present study was better characterize molecular mechanism by which AFB1 exerts hepatotoxicity cattle. The bovine fetal hepatocyte cell line (BFH12) exposed for 48 h three different concentrations (0.9 µM, 1.8 µM 3.6 µM)....
Abstract Aflatoxin B1 (AFB1) is a pro-carcinogenic compound bioactivated in the liver by cytochromes P450 (CYPs). In mammals, CYP1A and CYP3A are responsible for AFB1 metabolism, with formation of genotoxic carcinogens AFB1-8,9-epoxide AFM1, detoxified metabolite AFQ1. Due to climate change, cereals contamination arose Europe. Thus, cattle, as other farm animals fed grains (pig, sheep broiler), more likely exposed via feed consequent release AFM1 milk, posing great concern human health....
In human, the cytochrome P450 3A (CYP3A) subfamily of drug-metabolizing enzymes (DMEs) is responsible for a significant number phase I reactions, with CYP3A4 isoform superintending hepatic and intestinal metabolism diverse endobiotic xenobiotic compounds. The CYP3A4-dependent bioactivation chemicals may result in hepatotoxicity trigger carcinogenesis. cattle, four CYP3A genes (CYP3A74, CYP3A76, CYP3A28 CYP3A24) have been identified. Despite cattle being daily exposed to xenobiotics (e.g.,...
Among veterinary antibiotics, flumequine (FLU) is still widely used in aquaculture due to its efficacy and cost-effectiveness. Although it was synthesized more than 50 years ago, a complete toxicological framework of possible side effects on non-target species far from being achieved. The aim this research investigate the FLU molecular mechanisms Daphnia magna, planktonic crustacean recognized as model for ecotoxicological studies. Two different concentrations (2.0 mg L-1 0.2 L-1) were...
Aflatoxin B1 (AFB1) is a major food safety concern, threatening the health of humans and animals. Bentonite (BEN) an aluminosilicate clay used as feed additive to reduce AFB1 presence in contaminated feedstuff. So far, few studies have characterized BEN toxicity efficacy vitro. In this study, cytotoxicity (WST-1 test), effects on cell permeability (trans-epithelial electrical resistance lucifer yellow dye incorporation), transcriptional changes (RNA-seq) caused by BEN, their combination...