A5069444055- Trypanosoma species research and implications
- Biochemical and Molecular Research
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
University of California, Los Angeles
2022-2024
Motility of pathogenic protozoa depends on flagella (synonymous with cilia) axonemes containing nine doublet microtubules (DMTs) and two singlet microtubules. Microtubule inner proteins (MIPs) within DMTs influence axoneme stability motility provide lineage-specific adaptations, but individual MIP functions assembly mechanisms are mostly unknown. Here, we show in the sleeping sickness parasite Trypanosoma brucei, that FAP106, a conserved at DMT junction, is required for trypanosome as...
is a human and animal pathogen that depends on flagellar motility for transmission infection. The trypanosome flagellum built around canonical "9+2" axoneme, containing nine doublet microtubules (DMTs) surrounding two singlet microtubules. Each DMT contains 13-protofilament A-tubule 10-protofilament B-tubule, connected to the by conserved, non-tubulin inner junction (IJ) filament made up of alternating PACRG FAP20 subunits. Here we investigate in procyclic form
Trypanosoma brucei is a human and animal pathogen that depends on flagellar motility for transmission infection. The trypanosome flagellum built around canonical "9+2" axoneme, containing nine doublet microtubules (DMTs) surrounding two singlet microtubules. Each DMT contains 13-protofilament A-tubule 10-protofilament B-tubule, connected to the by conserved, non-tubulin inner junction (IJ) filament made up of alternating PACRG FAP20 subunits. Here we investigate in procyclic form T. . A...
ABSTRACT Motility of pathogenic protozoa depends on flagella (synonymous with cilia) axonemes containing nine doublet microtubules (DMTs) and two singlet microtubules. Microtubule inner proteins (MIPs) within DMTs influence axoneme stability motility provide lineage-specific adaptations, but individual MIP functions assembly mechanisms are mostly unknown. Here, we show in the sleeping sickness parasite Trypanosoma brucei , that FAP106, a conserved at DMT junction, is required for trypanosome...