A5077513765- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Drug Delivery Systems
- Corneal Surgery and Treatments
- Computational Drug Discovery Methods
- Glaucoma and retinal disorders
- Nanoparticle-Based Drug Delivery
- Analytical Chemistry and Chromatography
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Bacterial Identification and Susceptibility Testing
- Cancer therapeutics and mechanisms
- RNA Interference and Gene Delivery
- Hormonal and reproductive studies
- Ovarian function and disorders
- Research on Leishmaniasis Studies
- Phytochemicals and Medicinal Plants
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacogenetics and Drug Metabolism
- Ocular Diseases and Behçet’s Syndrome
- Nanoplatforms for cancer theranostics
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Academy of Scientific and Innovative Research
2021-2024
Central Drug Research Institute
2019-2024
Council of Scientific and Industrial Research
2023
Weatherford College
2023
Dynamic emergence of microbial keratitis (MK) requires a promising therapeutic arsenal antifungal and antibacterial agents like voriconazole (VCZ) moxifloxacin (MOXI), respectively. Parallelly, another paradigm MK associated with ulcerative wounds cannot be left unnoticed antifibrotic remedy (pirfenidone, PIR) as an authalic antimicrobial to retain the primordial vision. For designing effective clinical cure, combination these three is required at dosage regimen. Following quest, we have...
Fenugreek seeds are used in numerous marketed herbal formulations with therapeutic benefits. Some of its bioactive components such as 4-hydroxyisoleucine, trigonelline, raffinose, and pinitol reported to possess potential activities, antibacterial, antidiabetic, stomach stimulant, anti-invasive, against hyperandrogenism other allied diseases, including polycystic ovary syndrome. A fully validated, selective, sensitive bioanalytical method for the simultaneous rapid quantification...
Purpose: Diabetic retinopathy (DR) is a microvascular retinal disease associated with chronic diabetes mellitus, characterized by the damage of blood vessels in eye. It projected to become leading cause blindness, given increasing burden diabetic population worldwide. The diagnosis and management DR pose significant challenges for physicians because involvement multiple biochemical pathways complexity ocular tissues. This review aims provide comprehensive understanding molecular implicated...
A novel, quick and precise RP-UHPLC analytical method for the simultaneous determination of moxifloxacin (MFX), voriconazole (VCZ) pirfenidone (PIR) was developed validated according to International Conference on Harmonization guidelines using a QbD-driven response surface Box-Behnken design. The considering selectivity, sensitivity, linearity, accuracy-precision, robustness, stability, limit detection quantification, respectively. Resolution between MFX, VCZ PIR achieved gradient elution...
Pirfenidone, initially indicated for lung fibrosis, has gone beyond its original purpose, and shown promise in eye care. This detailed review tracks evolution from treatment to aiding healing as evidenced by published literature. Pirfenidone's multifaceted attributes extend mitigating corneal inflammation, trauma. Through rigorous investigations, efficacy emerges diabetic retinopathy, macular degeneration, postoperative glaucoma interventions. As an unheralded protagonist, pirfenidone...
Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that prevalent in tropical countries, particularly developing regions of Asia and Africa. Factors like lens misuse, inappropriate steroid use, diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, deformities. Accurate pathological diagnosis crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves...
The progressive development of tumors leading to angiogenesis marks the advancement cancer which requires specific targeted treatment preferably with combination chemotherapy.
Abstract Managing ocular microbial infections typically requires pharmacotherapy using antibiotic eye drops, such as moxifloxacin hydrochloride (MFX), combined with an antifungal agent like amphotericin B (AB). We carried out and validated LC–MS/MS assay to quantify these compounds in rabbit tear fluid order look into the pharmacokinetics of two drugs. employed a protein precipitation technique for extraction drugs under examination. A Waters Symmetry C 18 column was used separate analytes...
Aim: To study the preclinical pharmacokinetics of 4-hydroxy isoleucine (4-HIL) targeted for polycystic ovary syndrome. Methodology: The quantitative bioanalysis 4-HIL in different biological matrices female Sprage-Dawley rats using LC-MS/MS. Results: At 50 mg/kg, had 56.8% absolute oral bioavailability. It was quickly absorbed and distributed various tissues order small intestine > kidney spleen lung liver heart brain after administration. Moreover, 11.07% recovered urine feces within 72 h....
Background: Chebulinic acid (CA) is an active constituent of Terminalia chebula fruits with therapeutic potential against multiple metabolic diseases, including dementia, benign prostate hyperplasia, and osteoporosis. Objective: The present work intends to explore the preclinical pharmacokinetics, absolute bioavailability CA its influence on gene expression cytochrome P450 enzymes in liver. Methods: Quantifying probe drugs vitro samples serum male SD rats were performed using LC-MS/MS....
ABSTRACT Bacterial keratitis (BK) is an infection that causes inflammation of the cornea and, if severe, can result in blindness. Topical fluoroquinolones combined with corticosteroids have been shown to be useful treatment BK. A rapid, selective, and sensitive bioanalytical method for simultaneous quantification Gatifloxacin (GAT) Dexamethasone (DEX) has developed validated using tandem mass spectrometry (LC–MS/MS). Optimal separation was accomplished under 5 min Agilent Zorbax C18 column...