A5088383933- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Drug Delivery Systems
- Computational Drug Discovery Methods
- Corneal Surgery and Treatments
- Bacterial Identification and Susceptibility Testing
- Natural Antidiabetic Agents Studies
- Hormonal and reproductive studies
- Glaucoma and retinal disorders
- Ovarian function and disorders
- Analytical Chemistry and Chromatography
- Cancer therapeutics and mechanisms
- Intraocular Surgery and Lenses
- Genetics, Bioinformatics, and Biomedical Research
- Diet, Metabolism, and Disease
- HER2/EGFR in Cancer Research
- Pharmacological Effects of Medicinal Plants
- Ginseng Biological Effects and Applications
- Pharmacology and Obesity Treatment
- Herbal Medicine Research Studies
- Quinazolinone synthesis and applications
- Biotechnology and Related Fields
- Retinal Diseases and Treatments
- Advancements in Transdermal Drug Delivery
Central Drug Research Institute
2021-2024
Jawaharlal Nehru University
2021-2024
Weatherford College
2023
Council of Scientific and Industrial Research
2023
Academy of Scientific and Innovative Research
2022
Dynamic emergence of microbial keratitis (MK) requires a promising therapeutic arsenal antifungal and antibacterial agents like voriconazole (VCZ) moxifloxacin (MOXI), respectively. Parallelly, another paradigm MK associated with ulcerative wounds cannot be left unnoticed antifibrotic remedy (pirfenidone, PIR) as an authalic antimicrobial to retain the primordial vision. For designing effective clinical cure, combination these three is required at dosage regimen. Following quest, we have...
Fenugreek seeds are used in numerous marketed herbal formulations with therapeutic benefits. Some of its bioactive components such as 4-hydroxyisoleucine, trigonelline, raffinose, and pinitol reported to possess potential activities, antibacterial, antidiabetic, stomach stimulant, anti-invasive, against hyperandrogenism other allied diseases, including polycystic ovary syndrome. A fully validated, selective, sensitive bioanalytical method for the simultaneous rapid quantification...
Purpose: Diabetic retinopathy (DR) is a microvascular retinal disease associated with chronic diabetes mellitus, characterized by the damage of blood vessels in eye. It projected to become leading cause blindness, given increasing burden diabetic population worldwide. The diagnosis and management DR pose significant challenges for physicians because involvement multiple biochemical pathways complexity ocular tissues. This review aims provide comprehensive understanding molecular implicated...
A novel, quick and precise RP-UHPLC analytical method for the simultaneous determination of moxifloxacin (MFX), voriconazole (VCZ) pirfenidone (PIR) was developed validated according to International Conference on Harmonization guidelines using a QbD-driven response surface Box-Behnken design. The considering selectivity, sensitivity, linearity, accuracy-precision, robustness, stability, limit detection quantification, respectively. Resolution between MFX, VCZ PIR achieved gradient elution...
Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that prevalent in tropical countries, particularly developing regions of Asia and Africa. Factors like lens misuse, inappropriate steroid use, diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, deformities. Accurate pathological diagnosis crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves...
Abstract Managing ocular microbial infections typically requires pharmacotherapy using antibiotic eye drops, such as moxifloxacin hydrochloride (MFX), combined with an antifungal agent like amphotericin B (AB). We carried out and validated LC–MS/MS assay to quantify these compounds in rabbit tear fluid order look into the pharmacokinetics of two drugs. employed a protein precipitation technique for extraction drugs under examination. A Waters Symmetry C 18 column was used separate analytes...
Aim: To study the preclinical pharmacokinetics of 4-hydroxy isoleucine (4-HIL) targeted for polycystic ovary syndrome. Methodology: The quantitative bioanalysis 4-HIL in different biological matrices female Sprage-Dawley rats using LC-MS/MS. Results: At 50 mg/kg, had 56.8% absolute oral bioavailability. It was quickly absorbed and distributed various tissues order small intestine > kidney spleen lung liver heart brain after administration. Moreover, 11.07% recovered urine feces within 72 h....
Background: Chebulinic acid (CA) is an active constituent of Terminalia chebula fruits with therapeutic potential against multiple metabolic diseases, including dementia, benign prostate hyperplasia, and osteoporosis. Objective: The present work intends to explore the preclinical pharmacokinetics, absolute bioavailability CA its influence on gene expression cytochrome P450 enzymes in liver. Methods: Quantifying probe drugs vitro samples serum male SD rats were performed using LC-MS/MS....
Abstract A simple, fast, and responsive liquid chromatography‐tandem mass spectrometry method was established fully validated according to the United States Food Drug Administration guidelines for simultaneous quantitation of ofloxacin dexamethasone in tear fluid partially aqueous humor cornea. Samples were cleaned‐ up by single‐step precipitation using methanol as an anti‐solvent. Agilent SB C 18 column with 4.5 min total run time used chromatographic separation utilizing isocratic mode....
S-011-1559 is a tyrosine-derived novel benzoxazine CDRI molecule targeted to the oestrogen-related receptor (ER-α/β) modulator in breast cancer. To explore pharmacokinetics of S-011-1559, selective and sensitive bioanalytical method using LC-MS/MS was established validated different biological matrices female rats.Blood-to-plasma ratio plasma protein binding (PPB) were found be <1 >97% both rats humans, respectively. The human serum albumin (HSA) alpha-1-acid glycoprotein (AAG) range > 68...
Abstract Chebulinic acid (CA), a polyphenolic compound extracted from the fruits of Terminalia chebula, has been recently reported as novel neuraminidase inhibitor against influenza A virus and also for various biological activities that require pharmacokinetic estimation. We report proposed fragmentation pathway formation selection sodium ammonium adducts using molecular thermodynamics. The chebulinic adduct was reproducible stable compared to earlier quantify by liquid...