A5044879443- Bone Metabolism and Diseases
- Organometallic Compounds Synthesis and Characterization
- Bone health and treatments
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Bone Tissue Engineering Materials
- Crystallization and Solubility Studies
- Luminescence Properties of Advanced Materials
- MicroRNA in disease regulation
- Glass properties and applications
- Orthopaedic implants and arthroplasty
- Bone health and osteoporosis research
- X-ray Diffraction in Crystallography
- Sesquiterpenes and Asteraceae Studies
- Vehicle License Plate Recognition
- Synthesis and Characterization of Heterocyclic Compounds
- Titanium Alloys Microstructure and Properties
- Genetics and Plant Breeding
- Adsorption and biosorption for pollutant removal
- Estrogen and related hormone effects
- Medicinal plant effects and applications
- Indian Economic and Social Development
- Synthesis of Organic Compounds
- Phytochemical compounds biological activities
- Synthesis and Reactivity of Heterocycles
Central Drug Research Institute
2021-2024
Academy of Scientific and Innovative Research
2021-2024
National Bureau of Plant Genetic Resources
2024
University of Toronto
2024
Birla Institute of Technology and Science - Hyderabad Campus
2018
Birla Institute of Technology and Science, Pilani
2018
Anti-resorptive inhibitors such as bisphosphonates are widely used but they have limited efficacy and serious side effects. Though subcutaneous injection of teriparatide [PTH (1-34)] is an effective anabolic therapy, long-term repeated administration not recommended. Henceforth, orally bio-available small-molecule-based novel therapeutics unmet medical needs to improve the treatment. In this study, we designed, synthesized, carried out a biological evaluation 31 pyrimidine derivatives potent...
The presence of harmful contaminants in the waste stream is an important concern worldwide. convergence biotechnology and nanoscience offers a sustainable alternative treating contaminated waters. Hexavalent chromium, being carcinogenic deserves effective methods for sequestration. Here in, we report immobilization prokaryote (Rhizobium) eukaryote (Saccharomyces cerevisiae) multiwalled carbon nanotubes (MWCNTs) adsorption hexavalent chromium. carboxylic groups were introduced into MWCNTs...
Complexes of copper(II) with 5(2′-hydroxyphenyl)-3-(4-x-phenyl)pyrazolines, (C15H12N2OX)2Cu [X =–H,–Cl,–CH3,–OCH3] have been synthesized their addition complexes 2,2′-bipyridine, 1,10-phenanthroline and triphenylphosphine. The were characterized by elemental analyses, molecular weight measurement, magnetic, conductivity IR, electronic, 31P NMR, ESR FAB mass spectra. examined for crystalline/amorphous nature through XRD. Square-planar geometry around is suggested two bidentate pyrazoline...
Abstract Osteoporosis is a metabolic bone disorder associated with impaired microarchitecture leading to fragility fractures. Long‐term usage of parathyroid hormone (PTH) enhances resorption and leads osteosarcoma in rats which limits its exposure maximum 2 years human. Notably, the anabolic effects PTH do not endure absence sustained administration. Studies our lab identified osteogenic antiresorptive activity medicarpin, phytoestrogen belonging pterocarpan class. Considering dual‐acting...
Iron(III)5(2′-hydroxyphenyl)-3-(4-X-phenyl)pyrazolinates of the type (C15H12N2OX)3Fe [where X =–H,–Cl,–CH3,–OCH3] have been synthesized by reaction anhydrous FeCl3 with sodium salts pyrazoline in 1 : 3 molar ratio. Their addition complexes N and P donor ligands [2,2′-bipyridine, 1,10-phenanthroline triphenylphosphine] were prepared 1:1 These newly derivatives characterized using elemental analysis (C, H, Fe), molecular weight measurement, magnetic moment data, FAB mass, 31P NMR Mössbauer...
Abstract 5(2′-Hydroxyphenyl)-3-(4-substituted-phenyl)pyrazolinates of cobalt(II) the type (C15H12N2OX)2Co [here substituted group X is–H,–Cl,–CH3 or–OCH3] have been synthesized by reaction anhydrous cobalt(II)chloride with sodium salt pyrazolines in 1 : 2 molar ratio. Their addition complexes N and P donor ligands [2, 2′-bipyridine, 1, 10-phenanthroline triphenylphosphine] were prepared The newly characterized elemental analyses, molecular weight measurement, magnetic susceptibility, IR,...
Synthesis, spectral, biological, and anti-inflammatory investigations of a series complexes zinc(II) with 5-(2′-hydroxyphenyl)-3-(4-X-phenyl)pyrazolines the type (C15H12N2OX)2Zn (where X =–H,–Cl,–CH3,–OCH3) are presented. The were synthesized by reaction anhydrous chloride sodium salts pyrazoline in 1 : 2 molar ratio. Adducts N P donor ligands (2,2′-bipyridine, 1,10-phenanthroline triphenylphosphine) prepared characterized elemental analyses, molecular weight, conductivity, IR, electronic,...
A number of complexes nickel(II) with 5(2′-hydroxyphenyl)-3-(4-X-phenyl)pyrazolines the type (C15H12N2O ··· X)2Ni [where X = H, Cl, CH3 and OCH3] were synthesized by reaction anhydrous chloride sodium salts pyrazoline in 1 : 2 molar ratio. Their addition 2,2′-bipyridine, 1,10-phenanthroline triphenylphosphine prepared These characterized elemental analyses, molecular weight, magnetic, conductivity, IR, electronic, 1H, 13C, 31P NMR FAB mass spectral data. All are amorphous. Square planar...
In this work, a new series of 3-aryl-2H-chromene derivatives were rationally designed based on natural isoflavonoids, and synthesized through ring transformation 2H-pyran-2-ones using 3-acetyl-2H-chromene in quest for identifying osteogenic agents. From primary screening, five compounds (8a, 8b, 8e, 8g, 8i) found active osteoblast differentiation. Among all, the most compound 8i showed significantly enhanced calcium nodule formation at 1pM 100pM; increased cell viability. Western blotting...
Heat stress in Brassica is a great threat to its productivity and it major abiotic challenge the current scenario of changing global climatic conditions. Oil production from second largest after soybean, globally. In this study, 32 Indian mustard accessions were evaluated (post-anthesis stage) under heat field conditions during rabi season 2019-20, by being exposed 3 different growing i.e., early, optimum late sowing. Biochemical assays performed at post-anthesis stage analyze...
Estrogen deficiency is one of the main causes for postmenopausal osteoporosis. Current osteoporotic therapies are high cost and associated with serious side effects. So there an urgent need cost-effective anti-osteoporotic agents. Anti-osteoporotic activity Litsea glutinosa extract (LGE) less explored. Moreover, its role in fracture healing mechanism action still unknown. In present study we explore osteoprotective potential LGE osteoblast cells fractured ovariectomized (Ovx) mice models....
Aim: The intent of the study was to assess bone conserving effect Butea monosperma total extract (BTE) prepared from stem-bark, in ovariectomy (Ovx)-induced loss Sprague Dawley (SD) rats.
 Methods: Sprague-Dawley rats were ovariectomized (Ovx) and BTE treatment with three different doses (100mg, 250mg 500mg/kg body weight) commenced a day after Ovx continued for 12 weeks. Skeletal parameters including trabecular cortical microarchitecture, mineral density, content, biomechanical...
Bone healing and regeneration is a complex process that recapitulates embryonic skeletal development delayed in diseases like osteoporosis. therapies recombinant bone morphogenetic-2 protein (rhBMP-2) parathyroid hormone (PTH), an approved anabolic therapy reduces fracture risks but are fraught with high cost several side effects. Thus, there unmet need for cost-effective agents. In this study, we have synthesized 3-piperidinylethoxypterocarpan (3-PEP) which hybrid of supplement ipriflavone...