A5006238285- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Essential Oils and Antimicrobial Activity
- Peptidase Inhibition and Analysis
- Bone Metabolism and Diseases
- Antimicrobial Peptides and Activities
- Microbial Natural Products and Biosynthesis
- Probiotics and Fermented Foods
- Bone health and osteoporosis research
- Synthesis and Characterization of Pyrroles
- Studies on Chitinases and Chitosanases
- Process Optimization and Integration
- Berberine and alkaloids research
- Autophagy in Disease and Therapy
- Innovation and Socioeconomic Development
- Medicinal Plants and Neuroprotection
- Neuropeptides and Animal Physiology
- Epoxy Resin Curing Processes
- Epigenetics and DNA Methylation
- Food Chemistry and Fat Analysis
- Plant-based Medicinal Research
- Catalysis for Biomass Conversion
- Injection Molding Process and Properties
- Fungal Infections and Studies
Academy of Scientific and Innovative Research
2022-2025
Central Drug Research Institute
2022-2025
Indian Institute of Technology Kharagpur
2019-2024
Shiv Nadar University
2024
Galgotias University
2022
Jamia Millia Islamia
2018-2020
Jawaharlal Nehru University
2017-2019
Multidrug-resistant Klebsiella pneumoniae has emerged as one of the deadliest opportunistic nosocomial pathogens that forms biofilm for establishment chronic K. infections. Herein, we made an attempt to identify genes involved in formation strain ATCC13883. To achieve this, constructed mini-Tn5 transposon insertion mutants and screened them production. We observed was enhanced mutant where wcaJ gene disrupted. WcaJ is initiating enzyme colanic acid synthesis loads first sugar (glucose-1-P)...
Anti-resorptive inhibitors such as bisphosphonates are widely used but they have limited efficacy and serious side effects. Though subcutaneous injection of teriparatide [PTH (1-34)] is an effective anabolic therapy, long-term repeated administration not recommended. Henceforth, orally bio-available small-molecule-based novel therapeutics unmet medical needs to improve the treatment. In this study, we designed, synthesized, carried out a biological evaluation 31 pyrimidine derivatives potent...
Exploring sustainable approaches to replace petroleum-based chemicals is an ongoing challenge in reducing the carbon footprint. Due complexity and percentage variation nature-generated molecules, which further varies based on geographical origin purification protocol adopted, a better isolation strategy for individual components required. Agrowaste from cashew industry generates phenolic lipid (cardanol)-rich nutshell liquid (CNSL) has recently shown extensive commercial utility. Cardanol...
The pathogenicity of Candida albicans, an opportunistic human fungal pathogen, is attributed to several virulence factors. β-citronellol a monoterpenoid present in plant essential oils. study explores the antifungal potential and mode action against C. albicans ATCC 90028 (standard), D-27 (FLC-sensitive), S-1 (FLC-resistant). Anti-Candida was studied by performing MIC, MFC, growth curves, disc diffusion, spot assay, WST1 cytotoxic assay. Morphological transition monitored microscopically...
Fungal pathogens such as Candida albicans exhibit several survival mechanisms to evade attack by antifungals and colonise host tissues. Rta3, a member of the Rta1-like family lipid-translocating exporters has 7-transmembrane domain topology, similar G-protein-coupled receptors is unique fungal kingdom. Our findings point towards role for plasma membrane localised Rta3 in providing tolerance miltefosine, an analogue alkylphosphocholine, maintaining mitochondrial energetics. Concurrent with...
β-citronellol, an acyclic monoterpenoid, inhibits dose-dependent growth of C. glabrata and tropicalis with MIC/MFC values 400 µg/ml/600 µg/ml 100 µg/ml/200 µg/ml, respectively. Below MIC, the compound was more toxic to but inhibition extracellular proteinases higher in tropicalis. Significant phospholipase activity not observed both cases. Membrane ergosterol content decreased at concentrations above MIC/4; being greater Interestingly β-citronellol showed significantly better comparison FLC....
Hypoxic adaptation pathways, essential for Candida albicans pathogenesis, are tied to its transition from a commensal pathogen. Herein, we identify WW domain-containing protein, Ifu5, as determinant of hypoxic that also impacts normoxic responses in this fungus. Ifu5 activity supports glycosylation homeostasis via the Cek1 mitogen-activated protein kinase-dependent up-regulation PMT1, under normoxia. Transcriptome analysis ifu5Δ/Δ normoxia shows significant regulator EFG1 and EFG1-dependent...
ABSTRACT Ion transporters or channels are involved in maintaining metal homeostasis bacterial cells by aiding the movement of ions across cell, which might also facilitate export antimicrobials. Ubiquitous magnesium transporter, CorA Mycobacterium smegmatis is well known for its role homeostasis. However, little about involvement exerting antimicrobial resistance. Here, with help molecular genetics, vivo and silico studies we tried to envisage M. resistance E. coli . Expression corA...
Abstract With the growing threat of drug-resistant Acinetobacter baumannii , there is an urgent need to comprehensively understand physiology this nosocomial pathogen. As penicillin-binding proteins are attractive targets for antibacterial therapy, herein we have tried explore physiological roles two putative DD-carboxypeptidases, viz., dacC and dacD in A. . Surprisingly, deletion resulted a reduced growth rate, loss rod-shaped morphology, reduction biofilm-forming ability, enhanced...
Abstract With the growing threat of drug-resistant Acinetobacter baumannii, there is an urgent need to comprehensively understand physiology this nosocomial pathogen. As penicillin-binding proteins are attractive targets for antibacterial therapy, we have tried explore physiological roles two putative DD-carboxypeptidases, viz., DacC and DacD, in A. baumannii. Surprisingly, deletion dacC resulted a reduced growth rate, loss rod-shaped morphology, reduction biofilm-forming ability, enhanced...
Abstract Aim Ubiquitous magnesium transporter, CorA of Mycobacterium smegmatis is well known for its role in maintaining homeostasis. However, little about involvement exerting antimicrobial resistance. Here, by using molecular genetics, vivo and silico studies, we tried to envisage the M. resistance Escherichia coli. Methods results Expression corA E. coli decreased susceptibility host cells towards various antibiotics anti-tubercular drugs, which was elucidated determining minimum...
Haryana the cradle of Indus Valley and Vedic civilization is one wealthiest state India. The state's economy largely depends upon agriculture business process out sourcing. Many factors affect tender in Haryana. objective study to find most important independent that success sales Haryana, To meet this a survey was conducted data reduction technique “Factor Analysis” used factors. It found main three are namely “Safe Variety”, “Democratic Opinion” “Long Term Budget”. With these findings, can...
Antifungal potential of β-citronellol was studied on C. albicans, a commensal that causes both superficial and systemic infection in immunocompromised humans.This non-toxic natural compound displayed minimum inhibitory concentration (MIC) 200 µg/ml fungicidal at 350 µg/ml.On YPD agar, it formed inhibition zones (ZOI) 16.2 mm, 18.15 mm 19.25 respectively MIC, 2MIC 3MIC while fluconazole (FLC) ZOI 20.43 its MIC (disc diffusion assay).No growth observed above solid media (spot assay) ≥ liquid...
This research is conducted in order find out the reasons for hurdles IPP improvement and ways to improve them. IN each 8-hour shift Motherhub people working on Primary secondary stations sorting purpose are supposed segregate shipments based destinations of that they using scanners, there a way monitor their productivity. The pre-existing methods which were use Flipkart (Motherhub_JKS) not able calculate individual IPP, calculation average basis. method was unable track person, as management...