A5007074463- Genetic Associations and Epidemiology
- BRCA gene mutations in cancer
- Neurological and metabolic disorders
- Acute Ischemic Stroke Management
- Inflammatory Biomarkers in Disease Prognosis
- Atherosclerosis and Cardiovascular Diseases
- Dermatology and Skin Diseases
- Gene expression and cancer classification
- Diabetic Foot Ulcer Assessment and Management
- Genomic variations and chromosomal abnormalities
- Bioinformatics and Genomic Networks
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- IL-33, ST2, and ILC Pathways
Liaocheng People's Hospital
2023-2024
Osaka University
2022-2024
Shandong First Medical University
2023-2024
The Institute of Statistical Mathematics
2022
RIKEN Center for Integrative Medical Sciences
2022
The University of Tokyo
2022
Abstract Genome-wide association studies (GWAS) are overwhelmingly biased toward European ancestries. Nearly all existing agree that transferring genetic predictions from ancestries to other populations results in a substantial loss of accuracy. This is commonly referred as low portability polygenic risk scores (PRS) and one the most important barriers ethical clinical deployment PRS. Yet, it remains unclear how much various factors, such linkage disequilibrium (LD) differences, allele...
Abstract Atopic dermatitis (AD) is a skin disease heterogeneous both in terms of clinical manifestations and molecular profiles. It increasingly recognized that AD systemic rather than local should be assessed the context whole-body level biology. In this study, we integrated RNA-seq data PBMC along with from 115 patients matched 14 healthy controls aiming to comprehensively capture signature associated specific presentation. Analysis cross-tissue ligand-receptor coupling suggested increase...