A5089589550- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Caveolin-1 and cellular processes
- Microtubule and mitosis dynamics
- Global Cancer Incidence and Screening
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- PI3K/AKT/mTOR signaling in cancer
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Urinary and Genital Oncology Studies
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Developmental Biology and Gene Regulation
- Bladder and Urothelial Cancer Treatments
China Medical University
2018-2025
First Hospital of China Medical University
2020-2025
First Affiliated Hospital of Jinan University
2023-2024
Shanxi University
2024
Second Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
We report an elderly male with mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) and oligometastatic lung involvement, initially diagnosed as benign prostatic hyperplasia treated transurethral plasma resection (TURP). Postoperative pathology indicated mucinous adenocarcinoma, immunohistochemistry positive for CK7, CK20, CDX-2. Next-generation sequencing (NGS) identified genetic alterations similar to those found in intestinal adenocarcinoma. After ruling out...
Abstract NSCLC is common and the primary cause of cancer-related deaths due to a lack early diagnosis its propensity for metastasis. The pathogenesis still unclear. Here, we explored molecular mechanisms underlying development, focusing on HOXC-AS3/YBX1/HOXC8 axis. Human specimens cell lines were used. qRT-PCR western blotting utilised examine levels HOXC-AS3/YBX1/HOXC8. CCK-8, colony formation, scratch wound healing Transwell assays performed evaluate cancer proliferation, migration...
Tripartite motif-containing 67 (TRIM67), an E3 ubiquitin ligase, belongs to the TRIM protein family. The relationship between TRIM67 and tumorigenesis is not fully clear. Here, we elucidated function in non-small cell lung cancer (NSCLC). immunostaining results were correlated with clinicopathological features. Moreover, of cultured NSCLC cells was evaluated by MTT, colony formation, Transwell assays. expression associated tumor size, lymph node metastasis, p-TNM stage, differentiation, poor...
In a meta-analysis, the long noncoding RNA cancer susceptibility candidate 8 (CASC8) was found to be gene closely related lung cancer, but its functions in are unknown.In Cancer Genome Atlas database, expression of CASC8 significantly higher non-small cell than adjacent normal tissues, and high associated with poor prognosis patients adenocarcinoma.Silencing inhibited proliferation, migration, invasion lines.Silencing also promoted sensitivity osimertinib through Forkhead box M1...
Damage-regulated autophagy modulator 2(DRAM2) is associated with processes. However, the role of DRAM2 in progression human neoplasms still unknown. Here, we show that may act as an oncogenic regulator non-small cell lung cancer (NSCLC).Tumor specimens from 259 NSCLC patients were collected and analyzed. Transwell migration, cycle analysis, MTT colony formation assays performed to determine effect overexpression knockdown on NSCLC-cell migration proliferation. Western blotting confirmed...
Lung cancer remains the leading cause of cancer‐related death worldwide. Previous studies have shown that novel KIAA 0247 gene potentially targeted by tumor suppressor p53 may inhibit development several cancers. However, exact function in non‐small‐cell lung ( NSCLC ) is unknown. The purpose present study was to clarify role . expression evaluated tumors and adjacent normal tissues 197 patients immunohistochemistry real‐time PCR analyzed for association with clinicopathological parameters....
The expression of Kelch-like protein 18 (KLHL18) in non-small cell lung cancer (NSCLC) is lower than that normal tissue according to the Gene Expression Profiling Interactive Analysis database. KLHL18 a BTB domain and binds cullin 3 (CUL3). However, whether this complex participates ubiquitination-mediated degradation NSCLC unclear. Therefore, we aimed investigate role human cells. We found downregulated cells associated with poor prognosis. Further, its was significantly tumor node...
JMJD8 is a JmjC domain-containing protein that has not been widely examined, despite its potential role in malignant tumor development.The underlying biological functions and molecular mechanisms of non-small-cell lung cancer (NSCLC) remain unclear.Herein, we explored the relationship between activation malignancy pathways NSCLC.Immunohistochemical analyses revealed high expression significantly correlated with cell differentiation advanced TNM stages NSCLC.The overexpression promoted...
Abstract Mitotic spindle organizing protein 2A (MZT2A) is localized at the centrosome and regulates microtubule nucleation activity in cells. This study assessed role of MZT2A non–small‐cell lung cancer (NSCLC). Differential expression was bioinformatically using TCGA database, GEPIA Kaplan‐Meier survival data to determine association between NSCLC prognosis. Furthermore, tissue specimens were evaluated by immunohistochemistry. overexpressed or knocked down cells cDNA siRNA, respectively....
Abstract Lung cancer is the leading cause of cancer-related death worldwide. KLHL38 has been reported to be upregulated during diapause but downregulated after androgen treatment reversal androgen-dependent skeletal muscle atrophy. This study aimed clarify role in non-small cell lung (NSCLC). expression was evaluated tumor and adjacent normal tissues from 241 patients with NSCLC using immunohistochemistry real-time PCR, its association clinicopathological parameters analyzed. levels...
Purpose Competing-risk analysis was used to accurately assess prognostic factors for cancer-specific death in patients with adenocarcinoma of transverse colon (ATC), and the results were compared those from a conventional Cox regression analysis. Materials Methods Patients diagnosed ATC between 2000 2019 selected Surveillance, Epidemiology, End Results database. The crude mortality rates calculated their differences tested using Gray’s test, respectively. In performing multivariate analysis,...
Abstract Non‐small‐cell lung cancer (NSCLC) accounts for approximately 80% of cases. TBC1D23, a member the TBC/RABGAP family, is widely expressed in human tissues; however, its role NSCLC currently unknown. Immunohistochemical analysis was conducted on 173 paraffin‐embedded tissue sections from patients with 2014 to 2018 at First Affiliated Hospital China Medical University. MTT, colony formation assay, cell cycle scratch transwell Western blotting and real‐time PCR were employed multiple...
To investigate the status of breast cancer incidence, trends, and survival in women urban Shenyang from 2008-2017 using large Cancer Registry data.Breast incidence mortality data were abstracted between 2008 2017. The crude age-standardized rates calculated for each year. Average annual percentage changes (AAPC) used to describe change over time.A total 14,255 out 18,782,956 diagnosed with 2017 Shenyang. overall incidences 75.89 43.42 per 100,000, respectively. increased 61.93 100,000 90.07...
The aim of this study was to analyze the trend non-Hodgkin's lymphoma incidence and mortality in China from 1990 2019, along with assessing effects age, period, cohort, as well predict future trends.
Abstract Background : Mitotic spindle organizing protein 2A (MZT2A) is localized at the centrosome and regulates microtubule nucleation activity in cells. This study assessed role of MZT2A non-small cell lung cancer (NSCLC). Methods Differential expression was bioinformatically using Cancer Genome Atlas database, Gene Expression Profiling Interactive Analysis Kaplan-Meier survival data to determine association between NSCLC prognosis. Furthermore, tissue specimens from 132 patients were...
Abstract Background: Lung cancer is the second most prevalent type of worldwide; however, its death highest among all cancers. Previous studies have shown that MEX3A associated with Argonaute (Ago) and CDX2 proteins, which are important in tumor progression. High expression also known to negatively affect therapeutic impact radiotherapy chemotherapy. Therefore, we investigated role non-small cell lung (NSCLC).Methods: Tumor specimens were collected from 87 NSCLC patients who underwent...
Abstract Purpose: Lung cancer is one of the leading causes death worldwide. Sparc (osteonectin), cwcv, and Kazal-like domains proteoglycan 2 (SPOCK2) play important roles in development progression various types human cancers. However, role SPOCK2 non-small-cell lung (NSCLC) unclear. Hence, we aimed to elucidate NSCLC. Methods: Real-time PCR immunohistochemistry were used study relationship between expression clinicopathology was modulated using siRNA (knockdown) or pcmv6-myc-DDK-SPOCK2...
Abstract Background : The role of tetraspanins in cancer development has been widely reported. However, the expression and roles tetraspanin 3 (TSPAN3) solid tumors, including non-small cell lung (NSCLC), have not yet extensively investigated. In this study, we explored TSPAN3 NSCLC its potential trafficking integrin β1, which is highly expressed type cancer. Methods tissue lines was evaluated, correlation between disease progression assessed. Furthermore, loss- gain-of-expression studies...