A5092122526- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- CNS Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune cells in cancer
The Royal Melbourne Hospital
2023-2024
The University of Melbourne
2023
Australian Cancer Research Foundation
2023
Peter MacCallum Cancer Centre
2023
Poor graft function (PGF), manifested by multilineage cytopenias and complete donor chimerism post-allogeneic stem cell transplantation (alloSCT), acquired aplastic anaemia (AA) are immune-mediated bone marrow (BM) failure syndromes with a similar clinical presentation. In this study, we used spatial proteomics to compare the immunobiology of BM microenvironment identify common mechanisms immune dysregulation under these conditions. Archival trephines from patients exhibited downregulation...
Introduction: Inter-tumoral T cell dysfunction and efficacy of immune checkpoint inhibitors (ICI) in follicular lymphoma (FL) has been well described. However, few studies have examined peripheral blood immunity at diagnosis or the impact frontline ICI on circulating FL. We hypothesised that dysregulation would be present treatment naïve FL correlate to response ICI. Methods: PBMC samples from 34 untreated patients receiving rituximab (R) nivolumab (nivo) 1st FLOR trial (Hawkes JCO 2021)...
Topic: 20. Lymphoma Biology & Translational Research Background: Inter-tumoral T cell dysfunction and efficacy of immune checkpoint inhibitors (ICI) in follicular lymphoma (FL) has been well described. However, few studies have examined peripheral blood immunity at diagnosis or the impact frontline ICI on circulating FL. Aims: We hypothesised that dysregulation would be present treatment naïve FL correlate to response ICI.. Methods: PBMC samples from 34 untreated patients receiving rituxibab...