A5049428732- Lymphoma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Peroxisome Proliferator-Activated Receptors
- Metabolism and Genetic Disorders
- Molecular Communication and Nanonetworks
- CAR-T cell therapy research
- Environmental Impact and Sustainability
- Microfluidic and Bio-sensing Technologies
- Semiconductor Lasers and Optical Devices
- Sustainable Building Design and Assessment
- Optical Wireless Communication Technologies
- Microbial Inactivation Methods
- Building Energy and Comfort Optimization
- Nanoplatforms for cancer theranostics
- Pulsed Power Technology Applications
- Innovations in Concrete and Construction Materials
- CNS Lymphoma Diagnosis and Treatment
- Tactile and Sensory Interactions
- Innovative Human-Technology Interaction
- Biosensors and Analytical Detection
- Offshore Engineering and Technologies
- Scheduling and Optimization Algorithms
- Graphite, nuclear technology, radiation studies
- Chemical Safety and Risk Management
Box Hill Hospital
2022-2024
Eastern Health
2024
Austin Hospital
2024
Liverpool John Moores University
2021-2024
Singapore University of Technology and Design
2018-2022
Oak Ridge National Laboratory
2012-2017
Rice University
2015
The Alfred Hospital
2014
University of North Carolina at Chapel Hill
1995-1996
Peroxisomal genetic disorders, such as Zellweger syndrome, are characterized by defects in one or more enzymes involved the peroxisomal β-oxidation of very long chain fatty acids and associated with defective biogenesis. The biologic role system, which consists three enzymes: acyl-CoA oxidase (ACOX), enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (HD), thiolase, has been examined mice disrupting ACOX gene, encodes first rate-limiting enzyme this system. Homozygous (ACOX −/−) lacked...
The role of the enzyme lipoprotein lipase (LPL) in atherosclerosis is uncertain. To generate an animal model LPL deficiency, we targeted gene embryonic stem cells with a vector designed to disrupt COOH terminus protein and used these LPL-deficient mice. Germ line transmission disrupted allele was achieved two chimeric males, offspring from each animals were phenotypically identical. Pups homozygous (-/-) for deficiency died within 48 h birth extreme elevations serum triglycerides (13,327...
Developing novel nanostructures and advanced nanotechnologies for cancer treatment has attracted ever-increasing interest. Electrothermal therapy offers many advantages such as high efficiency minimal invasiveness, but finding a balance between increasing stability of the nanostructure state and, at same time, enhancing biodegradability presents key challenge. Here, we modulate biodegradation process two-dimensional-material-based by using polyethylene glycol (PEG) via disrupt-and-release...
Changes in lipid composition and structure during cell development can be markers for apoptosis or various diseases such as cancer. Although traditional fluorescence techniques utilising molecular probes have been studied, these methods are limited studying micro-changes they require complex probe preparation cannot reused, making monitoring detection challenging. Here, we developed a direct current (DC) resistance sensor based on two-dimensional (2D) molybdenum disulfide (MoS2) nanosheets...
Population-based studies have demonstrated a high risk of second cancers, especially the skin, among patients with chronic lymphocytic leukaemia (CLL). We describe age-standardised incidence ratios (SIRs) primary malignancies (SPM) in Australian relapsed/refractory CLL treated at least two lines therapy, including ibrutinib. From December 2014 to November 2017, 156 were identified from 13 sites enrolled Australasian Lymphoma and Related Diseases Registry, 111 had follow-up data on rates SPM....
RF technologies has facilitated communication including audio, images, video and data transmission. However, the spectrum is getting increasingly crowded, alternative methods to transfer need be explored. In this paper, software-hardware co-design implemented design audio synchronization transmission for an optical-through-air transceiver system. Besides transmission, performance of VLC system verified through testing serial text The experimental results show that can achieve up 4 Mb/s rate...
The ever-growing evidence of climate emergency continues to drive the need for innovative solutions reduce release anthropogenic harmful gases. Continuing heavily rely on energy originating from fossil fuels remains non-sustainable owing their limited, exhausting supplies, dependence politically insecure sources and adverse environmental impacts. These considerations, coupled with current desperate security, have driven research towards finding...
Promising results in clinical studies have been demonstrated by the utilization of electrothermal agents (ETAs) cancer therapy. However, a difficulty arises from balance between facilitating degradation ETAs, and at same time, increasing performance/stability required for highly efficient treatment. In this study, we controlled thermal signature MoS2 harnessing nanostructures with M13 phage (MNM) via structural assembling (hydrophobic interaction) phenomena developed combined PANC-1 cell-MNM...
The idea for the Knowledge Sharing Initiative (KSI) was born in 1999, when National Aeronautics and Space Administration (NASA) Academy of Program Project Leadership (APPL) director Dr. Edward Hoffman teamed up with Alexander Laufer, an engineering professor at University Maryland. They worked together on a project focused around management, which culminated book, Management Success Stories. impressed Laufer's expertise using storytelling to promote knowledge sharing among managers, NASA...
Long-term nondestructive monitoring of cells is significant importance for understanding cell proliferation, signaling, death, and other processes. However, traditional methods are limited to a certain range testing conditions may reduce viability. Here, we present microgap, multishot electroporation (M2E) system recovery up ∼2 h using ∼5 V pulses with excellent viability medium population. Electric field simulations reveal the bias-voltage- gap-size-dependent electric intensities in M2E...
The development of combined 2D-material-polymer-phage frameworks that can enhance cancer cell detection via the enhancement electrical conductivity.
The adoption of IoT enabled devices have led to higher risks EMI issues, especially in their power management. Particularly, rectifiers for are concerning. To mitigate this, one approach is use wide-bandgap semiconductor management, which reduces the devices' susceptibility and emission conducted EMI. One such example GaN semiconductors. However, low voltage, frequency systems, literature concerning performance with regards been sparse. This particularly important industries as medical field...
A combined alternating current pulse carbon nanotube platform that can enhance cancer cell-specific thermal ablation via Joule heating.
Biosensors are of vital significance for healthcare by supporting the management infectious diseases preventing pandemics and diagnosis life-threatening conditions such as cancer. However, advancement field can be limited low sensing accuracy. Here, we altered bioelectrical signatures cells using carbon nanotubes (CNTs) via structural loosening effects. Using an alternating current (AC) pulse under light irradiation, developed a photo-assisted AC sensor based on CNTs to differentiate between...
A few-volt nanosecond alternating-current stimulation method with an increased number of pulses exploiting orientational-disordering processes.
Buildings are a huge carbon emitter. Efforts being made to cut both embodied and operational emissions reduce the impact on built environment. This study aims compare Life Cycle Carbon Footprint (LCCF) LCC of two alternatives: refurbishment radical replacement an existing community centre building in Liverpool identify options that could achieve significant CO2 emission reductions economically viable way. The calculation methods standardised by UK's RICS (Royal Institute Chartered Surveyors)...
This research aims to determine the feasibility of converting a Grade II* listed building, built in 1667 and located within conservation area UK, into an eco-home by reducing energy consumption carbon emissions. The project explores facilitating change use from commercial building residential dwelling while significantly improving performance. A baseline performance assessment is carried out using combination infrared thermography, monitoring hygrothermal conditions, thermal modelling....