A5020900919- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- CAR-T cell therapy research
- Prostate Cancer Treatment and Research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Renal and related cancers
- Colorectal Cancer Treatments and Studies
- Neuroblastoma Research and Treatments
- Cancer Research and Treatments
- Radiation Dose and Imaging
- MRI in cancer diagnosis
- Thyroid Cancer Diagnosis and Treatment
- HER2/EGFR in Cancer Research
Austin Health
2015-2025
La Trobe University
2015-2025
The University of Melbourne
2014-2025
Olivia Newton-John Cancer Wellness & Research Centre
2016-2025
RMIT University
2024
Austin Hospital
2008-2020
Ludwig Cancer Research
2007-2015
Ludwig Cancer Research
2014
Epworth Hospital
2012
LBA602 Background: The increasing detection of renal masses presents a significant patient management challenge. Diagnostic options include cross-sectional imaging, which cannot reliably differentiate benign and malignant masses, biopsy, is invasive subject to sampling errors. These limitations highlight the unmet need for accurate noninvasive techniques guide management. Girentuximab monoclonal antibody that targets carbonic anhydrase IX (CAIX), an enzyme highly expressed in clear cell...
Abstract Purpose The recent development and approval of new diagnostic imaging therapy approaches in the field theranostics have revolutionised nuclear medicine practice. To ensure provision these a safe high-quality manner, training physicians qualified specialists is paramount. This required for trainees who are learning practice, ensuring minimum standards knowledge competency existing practising specialists. Methods address need curriculum that would be utilised at global level,...
Background. This study investigates the use of 18F-fluoromisonidazole (FMISO) PET-guided radiotherapy dose painting for potentially overcoming radioresistant effects hypoxia in head and neck squamous cell carcinoma (HNSCC). Material methods. The cohort consisted eight patients with HNSCC who were planned definitive radiotherapy. Hypoxic subvolumes automatically generated on pre-radiotherapy FMISO PET scans. Three plans each patient: a standard (STD) plan to 70 Gy, uniform escalation (UDE)...
The field of nuclear medicine traces its origin to the accidental discovery and naming radioactivity by Henri Becquerel Marie Curie in 1896 1905. In March 1936, Hamilton Stone California used "radiosodium," first artificially produced radioisotope, treat 3 patients with
Convolutional neural networks (CNNs) may improve response prediction in diffuse large B-cell lymphoma (DLBCL). The aim of this study was to investigate the feasibility a CNN using maximum intensity projection (MIP) images from 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) baseline scans predict probability time-to-progression (TTP) within 2 years and compare it with International Prognostic Index (IPI), i.e. clinically used score. 296 DLBCL 18F-FDG PET/CT collected...
Synthetic somatostatin analogs have been posed as a potential source of error in receptor imaging through interference with tumor detection; however, experimental models and clinical studies shown complex mechanism the effect octreotide on tumors. The aim this study was to assess whether <sup>68</sup>Ga-DOTATATE uptake before treatment long-acting differs from that after treatment. <b>Methods:</b> Thirty patients (15 men; age [mean ± SD], 64.6 13.4 y) who had intermediately differentiated...
TPS271 Background: Combination immune checkpoint inhibitors (ICI) with ipilimumab and nivolumab has been shown to induce adaptive responses in patients mCRPC, albeit resulting modest clinical benefit. There is growing evidence that radiation may enhance the activity of ICI by modulating tumour microenvironment. We hypothesize radionuclide 177 Lu-PSMA-617 result immunogenic cell death therefore synergise combination improve long term outcomes. EVOLUTION aims determine safety mCRPC. Methods:...
Introduction Glioblastoma is the most common aggressive primary central nervous system cancer in adults characterised by uniformly poor survival. Despite maximal safe resection and postoperative radiotherapy with concurrent adjuvant temozolomide-based chemotherapy, tumours inevitably recur. Imaging O-(2-[ 18 F]-fluoroethyl)-L-tyrosine (FET) positron emission tomography (PET) has potential to impact (RT) planning, distinguish between treatment-induced pseudoprogression versus tumour...
The Nuclear Medicine Global Initiative was formed in 2012 by 13 international organizations to promote human health advancing the field of nuclear medicine and molecular imaging supporting practice application medicine. first project focused on standardization administered activities pediatric resulted 2 articles. For its second chose explore issues impacting access availability radiopharmaceuticals around world. <b>Methods:</b> Information obtained survey responses from 35 countries...
ABT-806 is a tumor-specific antibody targeting the epidermal growth factor receptor (EGFR). This study assessed safety, biodistribution, and pharmacokinetics of <sup>111</sup>In-radiolabeled (ABT-806i) effects repeated doses on occupancy. <b>Methods:</b> Eligible patients had advanced tumors likely to express EGFR/EGFRvIII; adequate performance status organ function; measurable disease by RECIST 1.1. In cohort 1, 6 received bolus administration ABT-806i underwent SPECT followed whole-body...
In nuclear medicine, theranostics is a burgeoning development that rapidly being implemented worldwide. There an increasing need to provide multidisciplinary framework the practice of theranostics, ensuring patients receive this treatment safely and are secure in knowledge their health-care practitioners adequately trained. Nuclear medicine experts Australia have taken initiative producing set theranostic guidelines relevant Australian medical practice. These encompass specialist...
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Follicular lymphoma (FL) outcomes are heavily influenced by host immune activity with anti-tumor mitigated PD-1/PD-L1 pathway engagement. Combination CD20-directed therapy plus PD-1 inhibition (PD-1i) increases T-cell tumor killing and NK-cell antibody-dependent cell cytotoxicity (ADCC). Mounting evidence supports immune-priming using PD-1i before cancer-directed agents. Our multicentre, open-label, phase II 1st FLOR study (NCT03245021) enrolled 39 previously-untreated advanced-stage FL...