A5103175049- Ion channel regulation and function
- Plant and Fungal Species Descriptions
- Model-Driven Software Engineering Techniques
- Plant Diversity and Evolution
- Plant and animal studies
- Natural product bioactivities and synthesis
- HIV Research and Treatment
- Enzyme function and inhibition
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- Nephrotoxicity and Medicinal Plants
- HIV/AIDS Research and Interventions
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Mathematics Education and Teaching Techniques
- Rabbits: Nutrition, Reproduction, Health
- Molecular Biology Techniques and Applications
- Advanced Software Engineering Methodologies
- Software Engineering Research
- Sesquiterpenes and Asteraceae Studies
- Ion Transport and Channel Regulation
- Fish Biology and Ecology Studies
- Hemoglobin structure and function
- Genomics and Phylogenetic Studies
- Global Educational Reforms and Inequalities
Johns Hopkins University
1989-2025
Johns Hopkins Medicine
1989-2025
Royal Botanic Gardens, Kew
2024
Royal Botanic Garden Edinburgh
2023
Health Canada
2021
New Jersey Institute of Technology
2010-2015
State University of New York
1977-2013
SUNY Plattsburgh
1977-2013
Université de Reims Champagne-Ardenne
2007
Ludwig-Maximilians-Universität München
2007
As part of an institution-wide program to enhance the education physicians in diagnosing and treating alcohol dependence abuse, a comprehensive survey was conducted which all new admissions adult inpatient services The Johns Hopkins Hospital were screened for alcoholism. prevalence screen-positive alcoholism, by department, as follows: medicine (25%), psychiatry (30%), neurology (19%), obstetrics-gynecology (12.5%), surgery (23%). Detection rates house staff faculty caring those patients who...
Objective: To identify the effects of substance abuse status (active, former, and never) on utilization highly active antiretroviral therapy (HAART), medication adherence, virologic immunologic responses to therapy. Design: Prospective cohort study 764 HIV-1-infected patients who attended an urban HIV clinic participated in a standardized interview. Main Outcome Measures: Past HAART, self-reported nonadherence with therapy, changes HIV-1 RNA level CD4+ lymphocyte count relative prior peak...
The separation between the aP and PP resonances in NMR spectrum of intracellular ATP may be used to measure fraction total that is complexed M&+ and, thereby, estimate level free i n intact cells (Gupta, R.
We use high content cell analysis, live fluorescent imaging, and transmission electron microscopy approaches combined with inhibitors of cellular transport nuclear import to conduct a systematic study the mechanism interaction nonfunctionalized quantum dots (QDs) human blood monocyte-derived primary macrophages lines phagocytic, epithelial, endothelial nature. Live are shown be able rapidly uptake accumulate QDs in distinct compartment specifically size charge. show that smallest target...
A direct cytoplasmic connection between macrophages and potential antibody-producing cells has been demonstrated in lymph nodes spleen. This was observed the tissues from both immunized nonimmunized rabbits.
Measurements have been made of the fluxes thallous ions (Tl(+)) across membrane frog sartorius muscle fibers. These show that at an external concentration 74 microM influx is about 270 x 10(-15) moles/cm.(2) sec., while efflux from a with internal equal to above 5 sec. The increased order 300-fold during twitch, and Tl(+) reach steady-state distribution between fiber water Ringer solution very close corresponding ratio for K(+). High concentrations depolarize 58 mv. tenfold increase in...
The advent of highly active antiretroviral therapy (HAART) has reduced the incidence most AIDS-related opportunistic illnesses (OI) and death in HIV-infected individuals. We investigated whether there are demographic disparities HIV disease progression HAART era compared with before.HIV-infected patients an urban clinical practice USA were using survival methods for time to a new AIDS-defining OI or therapeutic 1 (monotherapy combination therapy; 1990--1995; n = 2016) versus 2 (HAART;...
In a case-control study to identify risk factors for fluconazole-resistant oroesophageal candidiasis in human immunodeficiency virus-infected patients, 25 patients with clinical and vitro were paired controls who had treatment-responsive been observed similar time periods. After their first episode of candidiasis, later developed fluconazole resistance more treated episodes than did matched (cases, 3.1; controls, 1.8; P = .004), lower median CD4 cell counts (11/mm3 vs. 71/mm3; greater...
In a glucose-free bicarbonate Ringer (5% CO2 in N2), insulin increased intracellular pH (pHi), as determined by [14C]dimethadione, 0.12 +/- 0.02 and stimulated glycolysis, monitored anaerobic lactate production, 42.9 3.5% paired frog sartorius muscles. The effect of on glycolysis was shown to vary approximately linearly with log [Na+]0, being converted mM Na+ 51.5 8.4% inhibition glycolysis. As the free-energy gradient varied decreasing [Na+]0 from 104 6.8 mM, changes glycolytic flux...
1. Insulin increased the rate of net Na extrusion from Na‐loaded frog skeletal muscle into glucose‐free Na‐Ringer. After a 90 min period efflux, insulin‐treated muscles contained approximately 11% less intracellular water than did their controls. This decrease in resulted an increase concentration K, [K + ] i , even though there was no definite effect upon K flux. In spite water, [Na lower those treated with 500 m‐u. insulin/ml. 2. consistently 22 efflux Na‐Ringer containing either 10 or 2·5...
At a concentration that stimulates the Na pump, insulin hyperpolarizes plasma membrane of frog sartorius in presence substrate-free Ringer. The hyperpolarization ranged from 3.5 to 7.3 mV and averaged 4.7 mV. Ouabain, 10(-4) M, completely blocked effect on potential. Moreover, ouabain reversed insulin-induced within 20 min. produced by was not associated with detectable increase ratio K+ permeability Na+ nor intracellular K+, although depletion near external surface cannot be excluded....
Sulfation of tissue sections which contained nonmetachromatic polysaccharides was done in an equivolume mixture concentrated sulfuric acid and glacial acetic at 0°C. The were washed successively water. Aqueous solutions toluidine blue, 1.5 × 10-4 M, used for staining. procedure produced a metachromatic substrate sites previously nonmetachromatic. Normal metachromasy unaffected. There no loss, damage or distortion the sections.
In human immunodeficiency virus (HIV) disease, neutropenia occurs most commonly in patients who are also severely immunosuppressed. It is not currently known whether an independent risk factor for the development of bacterial infection, which a potentially serious complication advanced HIV disease.We compared incidence infection between 118 neutropenic (absolute neutrophil count [ANC], < 1 x 10(9)/L) and nonneutropenic matched CD4+ lymphocyte count, use injecting drugs, follow-up time from...
Journal Article The Response of Connective Tissue Associated with Tumors the Skin Get access Richard D. Moore, Moore Search for other works by this author on: Oxford Academic Google Scholar John Stevenson, Stevenson Melvin Schoenberg American Clinical Pathology, Volume 34, Issue 2, 1 August 1960, Pages 125–130, https://doi.org/10.1093/ajcp/34.2.125 Published: 01 1960 history Received: 30 December 1959 Accepted: March
A single inoculation of statolon into mice with established Friend virus (FV) leukemia can suppress the viral infection and produce a clinical remission lasting many months. Eventually, however, most develop characteristic FV leukemia. Persistence activity in spleens during be demonstrated by cell transfer histopathologic studies. Transfer to normal large number spleen cells (10(7)) from produces leukemia, small (10(2)) immunity challenge. Histopathologic examination reveals clusters...