A5086035586- Diversity and Impact of Dance
- Child and Adolescent Psychosocial and Emotional Development
- Quantum Dots Synthesis And Properties
- Sport Psychology and Performance
- Infant Development and Preterm Care
- Physical Education and Pedagogy
- Chalcogenide Semiconductor Thin Films
- Ectopic Pregnancy Diagnosis and Management
- Family and Disability Support Research
- Immune cells in cancer
- Sports Performance and Training
- Phagocytosis and Immune Regulation
- Attention Deficit Hyperactivity Disorder
- Adolescent and Pediatric Healthcare
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Community Health and Development
- Estrogen and related hormone effects
- Substance Abuse Treatment and Outcomes
- Cell Adhesion Molecules Research
- Family Support in Illness
- Child and Adolescent Health
- Youth Development and Social Support
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Policy Implementation Science
University of Exeter
2020-2025
Heavitree Hospital
2025
Peninsula Research
2024
University of Plymouth
2024
Cornwall Partnership NHS Foundation Trust
2024
Guy's and St Thomas' NHS Foundation Trust
2020-2023
St Thomas' Hospital
1991-2022
University of Bath
2016-2021
Victoria University of Wellington
2021
Denison University
2021
Abstract Lipoxins (LX) are lipoxygenase-derived eicosanoids generated during inflammation. LX inhibit polymorphonuclear neutrophil (PMN) chemotaxis and adhesion putative braking signals for PMN-mediated tissue injury. In this study, we report that LXA4 promotes another important step in the resolution phase of inflammation, namely, phagocytosis apoptotic PMN by monocyte-derived macrophages (Mφ). triggered rapid, concentration-dependent uptake PMN. This bioactivity was shared stable synthetic...
ABSTRACT. Lipoxins (LX) are eicosanoids with antiinflammatory activity in glomerulonephritis (GN) and inflammatory diseases, hypersensitivity, ischemia reperfusion injury. It has been demonstrated that LXA<sub>4</sub> stimulates non-phlogistic phagocytosis of apoptotic polymorphonuclear neutrophils (PMN) by monocyte-derived macrophages (Mφ) <i>in vitro</i>, suggesting a role for LX as endogenous pro-resolution lipid mediators. is here reported LXA<sub>4</sub>, LXB<sub>4</sub>, the...
We use high content cell analysis, live fluorescent imaging, and transmission electron microscopy approaches combined with inhibitors of cellular transport nuclear import to conduct a systematic study the mechanism interaction nonfunctionalized quantum dots (QDs) human blood monocyte-derived primary macrophages lines phagocytic, epithelial, endothelial nature. Live are shown be able rapidly uptake accumulate QDs in distinct compartment specifically size charge. show that smallest target...
Individual differences in the growth and maturation have been shown to impact player performance development youth soccer. This study investigated Premier League academy players' experiences of participating a tournament bio-banded for biological maturation. Players (N = 66) from four professional soccer clubs aged 11 14 years between 85-90% adult stature participated tournament. competed three vs games on full size pitch with 25-min halves. Sixteen players 15-min focus groups were asked...
We report the preparation and luminescence enhancement of thioglycolic acid (TGA) stabilised CdTe quantum dots (QDs) for use as live cell imaging tools in THP-1 macrophage cells. Short irradiating times utilising a high powered Hg lamp resulted increases efficiencies up to ∼40% permit significantly enhanced cellular components. It was found that TGA-stabilised QDs traverse membrane, illuminating cytoplasm decorating nuclear membrane. These studies highlight potential photoetched probes...
The compartmentalization of size-tuned luminescent semiconductor nanocrystal quantum dots (QDs) in four distinctive cell lines, which would be representative the most likely environmental exposure routes to nanoparticles humans, is studied. cells are fixed and permeabilized prior addition QDs, thus eliminating any cell-membrane-associated effects due active QD uptake mechanisms or specificity signaling different types, but leaving intact putative physical subcellular barriers. All...
This study aimed to investigate academy football coaches’ perceptions and experiences of managing adolescent growth maturation within the constraints an English Premier League academy. Using a longitudinal mixed method design, 98 under 12–16 players were assessed for maturity status, velocities match performance grade. Interviews conducted in parallel, with their nine respective coaches. The quantitative qualitative data then combined generate rich, contextualised understanding. One case is...
Fluorescent magnetite nanocomposites based on magnetic nanoparticles, a polyhedral octaaminopropylsilsesquioxane and porphyrin derivative have been prepared. The intracellular uptake of the by macrophage bone osteoblast cells, their potential as MRI contrast agents, has demonstrated.
Watching nanowires grow! Self-organization of CdTe nanocrystals into luminescent (see picture) takes place in a standard physiological phosphate-buffered solution and is completed several hours, as demonstrated situ by means confocal microscopy. Luminescence Raman spectroscopy data evidence the occurrence recrystallization processes during nanowire formation. Supporting information for this article available on WWW under http://www.wiley-vch.de/contents/jc_2267/2004/z400330_s.html or from...
Abstract Background National clinical guidelines emphasise the need for good communication of information by clinicians to young people and their parent/carers about what expect during transition into adult services. Recent research indicates that in attention deficit hyperactivity disorder (ADHD), only a minority experience continuity care adulthood, with additional concerns quality transition. This qualitative analysis explored role plays from child mental health services ADHD,...
ABSTRACT Objective Around 80% of women with endometriosis have superficial (SE) rather than ovarian or deep (DE). However, to date, advances in non‐invasive, imaging‐based diagnosis been limited DE disease. The objective this study was determine whether we can detect SE on transvaginal ultrasound scan (TVS) by assessing the peritoneum pouch Douglas (POD). Methods This a retrospective diagnostic test following change practice include POD assessment for during TVS at tertiary London hospital....
In the UK, there has been a notable increase in referrals to specialist children’s mental health services. This, coupled with shortages of qualified staff, raised concerns about escalating occupational stress experienced by staff this sector. brief report, we present cross-sectional quantitative data from 97 members working one Child and Adolescent Mental Health Service (CAMHS) UK during spring 2023, reporting on their wellbeing, job satisfaction, burnout. Our findings reveal that over third...
Summary Background We previously demonstrated that low concentrations of a new antihistamine levocetirizine inhibited eosinophil transmigration through human microvascular endothelial cells. Objective Here, the inhibitory effect on adhesion to recombinant vascular cell molecule‐1 (rhVCAM)‐1 was examined under conditions shear stress using an in vitro model post‐capillary venules. Methods Eosinophils isolated from normal subjects were pre‐incubated with concentration range (10 −6 –10 −10 m )...
Reducing bullying is a public health priority. KiVa, school-based anti-bullying programme, effective in reducing Finland and requires rigorous testing other countries, including the UK. This trial aims to test effectiveness cost-effectiveness of KiVa child reported UK schools compared usual practice. The currently on-going. Recruitment commenced October 2019, however due COVID-19 pandemic resulting school closures was re-started 2020.Design: Two-arm pragmatic multicentre cluster randomised...
Background Evidence for parenting programs to improve wellbeing in children under three is inconclusive. We investigated the fidelity, impact, and cost-effectiveness of two delivered within a longitudinal proportionate delivery model (‘E-SEE Steps’). Methods Eligible parents with child ≤ 8 weeks were recruited into parallel two-arm, assessor blinded, randomized controlled, community-based, trial embedded economic process evaluations. Post-baseline randomization applied 5:1...
T cell activation and the resultant production of interleukin (IL-2) is a central response adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses several mechanisms evade both innate arms response. Here we demonstrate that liver biopsy specimens from individuals infected with had significantly lower levels IL-2 compared those other inflammatory diseases. Cell culture–grown particles inhibited by normal peripheral blood mononuclear cells, did serum HCV-infected...
Background A proportionate universal (PU) approach to early years’ service provision has been advocated improve children’s health and development reduce inequality, by ensuring that services provide timely high-quality parenting support commensurate with need. Process-oriented research is critical examine the factors contribute to, or hinder, effective delivery/implementation of such a model in community-based family services. This study aimed assess delivery, acceptability feasibility new...