A5089085536- Hearing, Cochlea, Tinnitus, Genetics
- Developmental Biology and Gene Regulation
- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Ear Surgery and Otitis Media
- Neurogenesis and neuroplasticity mechanisms
- Ferroptosis and cancer prognosis
- Plant Genetic and Mutation Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital heart defects research
Loyola University Chicago
2025
William Paterson University
2023-2025
Rutgers, The State University of New Jersey
2025
University of Sheffield
2005-2006
Emx2 is a homeodomain protein that plays critical role in inner ear development. Homozygous null mice die at birth with range of defects the CNS, renal system and skeleton. The cochlea shorter than normal about 60% fewer auditory hair cells. It appears to lack outer cells some supporting are either absent or fail differentiate. Many differentiate pairs although their bundles develop normally planar cell polarity compromised. Measurements suggest classic molecules not directly influenced by...
Pancreatic cancer (PDAC) cells experience nutrient starvation in a poorly perfused tumor microenvironment. Metabolic dependencies that protect PDAC from detrimental oxidative stress nutrient-restricted niche represent as tumor-specific targets. While the role of mitochondria supporting energy production and biosynthetic requirements has been well investigated, their contribution to maintaining intracellular redox homeostasis when are exposed limitation is unknown. Our results demonstrate...
Aberrant activation of transposable elements (TEs) has been a well-documented source genomic instability and disease, stemming from their insertion into genes imposition epigenetic effects on nearby loci. However, the extent to which disruptive involve concomitant or subsequent formation DNA:RNA hybrids (R-loops) remains unknown. Here we used immunoprecipitation followed by high-throughput sequencing (DRIP-seq) map R-loop profiles TEs satellites in D. melanogaster ovaries control rhino...
Abstract The auditory neuroblast cell line US/VOT‐N33 (N33), which is conditionally immortal, was studied as an in vitro model for the differentiation of spiral ganglion neurons (SGNs) and a candidate transplantation rodents. It expresses numerous molecular markers characteristic neuroblasts, including transcription factors GATA3, NeuroD, Brn3a Islet1, well neuronal cytoskeletal protein β3‐tubulin. displays active migratory behaviour vivo . In presence fibroblast growth FGF1 or FGF2 it...
We have studied the function of zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles gene expression during differentiation conditionally immortal cell lines derived to model specific types and developmental stages. tested applied a novel probabilistic method called gamma Model for Oligonucleotide Signals analyse hybridization signals from Affymetrix oligonucleotide arrays. Expression levels estimated this correlated closely (p<0.0001) across...
The endocannabinoidome (eCBome) is the expanded endocannabinoid system (ECS) and studies show that there a link between this how it modulates alcohol induced neuroinflammation. Using conditional knockout (cKO) mice with selective deletion of cannabinoid type 2 receptors (CB2Rs) in dopamine neurons (DAT- Cnr2 ) microglia (Cx3Cr1- ), we investigated CB2Rs modulate behavioral neuroinflammation by alcohol. Behavioral tests including locomotor wheel running activity, rotarod performance test,...