A5100421858- Foot and Ankle Surgery
- Diabetic Foot Ulcer Assessment and Management
- Tendon Structure and Treatment
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- Bone Tumor Diagnosis and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Bone and Joint Diseases
- Inflammatory mediators and NSAID effects
- MicroRNA in disease regulation
- Lower Extremity Biomechanics and Pathologies
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Neurological Disorders and Treatments
- Sports injuries and prevention
- Cell Adhesion Molecules Research
- Orthopedic Surgery and Rehabilitation
- Rheumatoid Arthritis Research and Therapies
- Total Knee Arthroplasty Outcomes
- Cancer, Lipids, and Metabolism
- Protease and Inhibitor Mechanisms
- Lipid metabolism and disorders
- Knee injuries and reconstruction techniques
Xi'an Honghui Hospital
2016-2025
Xi'an Jiaotong University
2016-2024
Northwest University
2022
Shaanxi University of Chinese Medicine
2022
Hanzhong People's Hospital
2020
Nanjing University
2017
Xiangya Hospital Central South University
2012
Central South University
2012
Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through pretreatment with pro-inflammatory cytokines is an evolving field investigation. However, underlying mechanisms have not been fully clarified. Here, we pretreated human umbilical cord-derived MSCs interleukin-1β (IL-1β) and evaluated their therapeutic effects in a cecal ligation puncture-induced sepsis model. We found that systemic administration IL-1β-pretreated (βMSCs) ameliorated symptoms murine more...
This study aimed to compare modified minimally invasive chevron osteotomy (MIC group) and traditional incision (TIC for correction of mild moderate hallux valgus deformity. retrospective enrolled 42 patients (60 feet) with deformities who were treated MIC or TIC between January 2020 June 2021. The divided into the groups according whether treatment received was invasive. group included 20 (28 feet), comprising 1 male 19 female patients; aged 37.15 ± 14.60 years, deformity in 12 cases (14 8...
Abstract Background Osteoarthritis (OA) is the most common form of arthritis and characterized by degradation articular cartilage inflammation synovial membrane. Fucosylation an important feature protein N/O-glycosylation involved in a variety pathological processes, including cancer. However, whether fucosylation impacts OA process unknown. Methods Total proteins were extracted from samples obtained patients with ( n = 11) rabbit models at different time points 12). OA-associated abnormal...
Abstract Ever since the first application of mesenchymal stem cell (MSC) transplantation treating human hematologic malignancies in 1995, MSC‐based treatments have demonstrated great therapeutic potential clinical settings. However, only a few therapy products been clinically approved. Accumulating evidence suggests that beneficial effects MSCs are mainly attributed to release paracrine factors or extracellular vesicles (EVs) rather than their mesodermal differentiation potential. Therefore,...
To explore clinical effect of the fifth metatarsal head excision and non-excision in rheumatoid arthritis (RA) forefoot deformity reconstruction.
Abstract Purpose This study aimed to compare modified minimally invasive chevron osteotomy (MIC group) and traditional incision (TIC for correction of mild moderate hallux valgus deformity. Methods retrospective enrolled 42 patients (60 feet) with deformities who were treated MIC or TIC between January 2020 June 2021. The divided into the groups according whether treatment received was invasive. group included 20 (28 feet), comprising 1 male 19 female patients; aged 37.15 ± 14.60 years,...
Objective To observe the effect of atorvastatin combined with insulin glargine on renal function in patients early diabetic nephropathy. Methods From January 2016 to March 2019, 100 nephropathy admitted Hanzhong 3201 Hospital Affiliated Xi′an Jiaotong University Medical School were selected as subjects. According random number table, divided into control group and observation group, 50 cases each group. All underwent diet control, blood pressure symptomatic treatment. Patients treated...
Abstract Background: Osteoarthritis (OA) is characterized by ECM degradation in chondrocytes and inflammation of the synovial membrane. Fucosylation a main type glycosylation, involved variety pathological processes, including cancer. However, whether fucosylation impacts OA process unknown. Methods: Total proteins were extracted from cartilage samples obtained patients with (n = 11), rabbit models at different time points 12). The OA-associated abnormal glycopatterns evaluated lectin...
To explore clinical effect of rotational Scarf osteotomy in treating hallux valgus (HV) with rotation the first metatarsal bone.From January 2018 to October 2019, 35 patients (40 feet) HV and deformity were treated osteotomy, including 5 males 30 females;aged from 25 76 years old an average (40.32±5.43) old. Hallux angle(HVA), intermetatarsal angle (IMA), distal articular (DMAA), length (FML) observed compared, American Orthopedic Foot Ankle Society(AOFAS) metatarsophalangeal interphalangeal...
Abstract Background There have been debates on the necessity of fibular osteotomy (FO) in supramalleolar (SMOT) for treatment varus ankle osteoarthritis. The purpose current study was to compare clinical and radiological outcomes between SMOT with without FO Methods group included 39 patients, 24 patients. basic information reached no significant difference groups. American Orthopedic Foot Ankle Society (AOFAS) ankle-hindfoot score, Osteoarthritis Scale (AOS), modified Takakura stage range...