A5011710489- Radiation Therapy and Dosimetry
- Spaceflight effects on biology
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Mitochondrial Function and Pathology
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Plant Genetic and Mutation Studies
- Gene expression and cancer classification
- Advanced Radiotherapy Techniques
- Astrophysics and Cosmic Phenomena
- Radiation Effects and Dosimetry
- Climate Change and Health Impacts
- Advanced X-ray and CT Imaging
- Carcinogens and Genotoxicity Assessment
- Electromagnetic Fields and Biological Effects
- Genetics, Aging, and Longevity in Model Organisms
University of Houston
2018-2024
University of California, Los Angeles
2021
Wyle (United States)
2016-2017
Johnson Space Center
2016
Understanding space radiation health effects is critical due to potential increased morbidity and mortality following spaceflight. We evaluated whether there evidence for excess cardiovascular disease or cancer in early NASA astronauts if a correlation exists between exposure mortality. Astronauts selected from 1959-1969 were included followed until death February 2017, with 39 of 73 individuals still alive at that time. Calculated standardized rates tested outcomes significantly below U.S....
Abstract NASA has employed high-throughput molecular assays to identify sub-cellular changes impacting human physiology during spaceflight. Machine learning (ML) methods hold the promise improve our ability important signals within highly dimensional data. However, inherent limitation of study subject numbers a spaceflight mission minimizes utility ML approaches. To overcome sample power limitations, data from multiple missions must be aggregated while appropriately addressing intra- and...
Recently reported studies considering nonlinearity in the effects of low-dose space radiation have assumed a nontargeted mechanism. To date, few analyses been performed to assess whether term is supported by available data. The Harderian gland data from Alpen et al. (published 1993 and 1994), Chang (2016) provide most diversity ions energies tumor induction model, including multiple high-energy charge particles. These can be used investigate various assumptions against linear region or cell...
The clinical efficacy of radiation therapy is mechanistically linked to ionization-induced free radicals that cause cell and tissue injury through direct indirect mechanisms. Free radical reaction dynamics are influenced by many factors can be manipulated static weak magnetic fields (WMF) perturb singlet-triplet state interconversion. Our study exploits this phenomenon directly increase ionizing (IR) dose absorption in tumors combining WMF with as a new effective method improve...
Although there has been extensive research done on the biological response to doses of ionizing radiation relevant radiodiagnostic procedures, very few studies have examined schemes similar those frequently utilized in CT exams. Instead a single exposure, exams are often made up series scans separated order minutes. DNA damage dose-response kinetics after and protocols were established both cultured (ESW-WT3) whole blood lymphocytes compared higher dose exposures. Both extent H2AX...
Abstract The space environment includes unique hazards like radiation and microgravity which can adversely affect biological systems. We assessed a multi-omics NASA GeneLab dataset where mice were hindlimb unloaded and/or gamma irradiated for 21 days followed by retinal analysis at 7 days, 1 month or 4 months post-exposure. compared time-matched epigenomic transcriptomic profiles resulting in total of 4178 differentially methylated loci regions, 457 expressed genes. Highest correlation...
Prediction of cancer risk from space radiation exposure is critical to ensure spaceflight crewmembers are adequately informed the risks they face when accepting assignments ambitious long-duration exploratory missions. Although epidemiological studies have assessed effects terrestrial radiation, no robust humans exposed exist support estimates exposure. Mouse data derived recent irradiation experiments provides valuable information successfully develop mouse-based excess models for assessing...
Purpose: To identify exam and patient parameters affecting the biological response to CT studies using in vivo ex blood samples. Methods: Blood samples were collected under IRB approval from 16 patients undergoing clinically-indicated exams. was procured prior to, immediately after 30minutes following irradiation. A sample of preexam placed on within region for analysis. Whole fixed collection stained γH2AX assess DNA damage (DDR). Median fluorescence treated compared non-irradiated control...
<title>Abstract</title> NASA has employed high-throughput molecular assays to identify sub-cellular changes impacting human physiology during spaceflight. Machine learning (ML) methods hold the promise improve our ability important signals within highly dimensional data. However, inherent limitation of study subject numbers a spaceflight mission minimizes utility ML approaches. To overcome sample power limitations, data from multiple missions must be aggregated while appropriately addressing...