A5069193143- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Research on Leishmaniasis Studies
- Wildlife Ecology and Conservation
- Service-Oriented Architecture and Web Services
- Ruminant Nutrition and Digestive Physiology
- Neurotransmitter Receptor Influence on Behavior
- Genetic and phenotypic traits in livestock
- Helminth infection and control
- Biochemical and Molecular Research
- Forensic Toxicology and Drug Analysis
- Parasite Biology and Host Interactions
- Advanced Database Systems and Queries
- Ecology and biodiversity studies
- Reproductive Physiology in Livestock
- Coenzyme Q10 studies and effects
- Distributed and Parallel Computing Systems
- Psychedelics and Drug Studies
National Institute on Drug Abuse
2016
South Texas Veterans Health Care System
2016
The University of Texas Health Science Center at San Antonio
2016
National Institute on Alcohol Abuse and Alcoholism
2016
Murdoch University
2012-2013
We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor Trypanosoma cruzi (T. cruzi), causative agent Chagas disease, and results structure–activity investigations leading to potent analogues with low nM IC50s in a T. whole cell vitro assay. Lead compounds suppressed blood parasitemia virtually undetectable levels after once daily oral dosing mouse models infection. Compounds are chemically tractable, allowing rapid optimization target biological activity drug...
New drugs for visceral leishmaniasis that are safe, low cost, and adapted to the field urgently required. Despite concerted efforts over last several years, number of new chemical entities suitable clinical development treatment Leishmania remains low. Here, we describe discovery preclinical DNDI-6174, an inhibitor cytochrome bc 1 complex activity originated from a phenotypically identified pyrrolopyrimidine series. This compound fulfills all target candidate profile criteria required...
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is an increasing threat to global health. Available medicines were introduced over 40 years ago, have undesirable side effects, and give equivocal results of cure in chronic stage disease. We report development two compounds, 6 (S)-7, with PCR-confirmed curative activity a mouse model established T. infection after once daily oral dosing for 20 days at mg/kg 10 (S)-7. Compounds (S)-7 potent vitro activity, are...
Illicit drug preparations often include more than one pharmacologically active compound. For example, cocaine and synthetic cathinones [e.g., 3,4-methylenedioxypyrovalerone (MDPV)] are mixed with caffeine before sale. Caffeine is likely added to these because it inexpensive legal; however, might also mimic or enhance some of the effects MDPV. In studies, male Sprague-Dawley rats were trained discriminate 10 mg/kg from saline, discriminative stimulus cocaine, caffeine, MDPV evaluated alone as...
Several physical and physiological indices have been used to assess white-tailed deer (Odocoileus virginianus) nutritional condition habitat quality. We tested whether reflected inferred circumstances under controlled conditions of dietary protein energy at 2 time scales. Our study adult female that were captured in southern Texas placed captivity. randomly assigned (n = 51) the long-term 4 diet groups representing a factorial combination levels each crude (CP) for 6 months. 31) short-term...
Background: Inhibitors of Trypanosoma cruzi with novel mechanisms action are urgently required to diversify the current clinical and preclinical pipelines. Increasing number diversity hits available for assessment at beginning discovery process will help achieve this aim. Results: We report evaluation multiple generated from a high-throughput screen identify inhibitors T. these studies two series currently in lead optimization. Lead compounds potently selectively inhibit growth vitro most...
The effects of contrasting (16L:8D vs. 8L:16D) photoperiods on fat accretion and growth in 19 white-tailed doe fawns (Odocoileus virginianus) from 9 September to 16 December 1981 were examined. Fawns exposed long days (LD fawns) delayed their autumn pelage change, whereas those short (SD underwent a normal molt. SD heavier accumulated more than LD counterparts. combined skeletal muscle viscera daylength contained 1,195 2,269 g 10 November December, respectively, as compared with 290 621 for...