A5088671983- Hair Growth and Disorders
- Pregnancy and preeclampsia studies
- Dermatologic Treatments and Research
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Geographic Information Systems Studies
- Gut microbiota and health
- Reproductive tract infections research
- Pulmonary Hypertension Research and Treatments
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Phytochemicals and Antioxidant Activities
- Lipid metabolism and disorders
- Innovative Approaches in Technology and Social Development
- Community Health and Development
- melanin and skin pigmentation
- Diabetes Management and Education
- Autoimmune Bullous Skin Diseases
- Neurogenesis and neuroplasticity mechanisms
- Human Mobility and Location-Based Analysis
- Smart Cities and Technologies
- Cardiovascular Issues in Pregnancy
- Nonmelanoma Skin Cancer Studies
- Transportation Planning and Optimization
- Lipoproteins and Cardiovascular Health
University of Toronto
2021-2025
University of California, San Francisco
2009-2024
Sunnybrook Health Science Centre
2024
Health Sciences Centre
2024
Mount Sinai Hospital
2022
Kulicke & Soffa (Singapore)
2018
Queen's University
2016
Florida International University
2009-2015
Western University
2013-2015
Earl Haig Secondary School
2011
Rationale: Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and apoptosis resistance. This cancer-like phenotype promoted increased cytosolic calcium ([Ca2+]cyto), aerobic glycolysis, mitochondrial fission.Objectives: To determine how changes in uniporter (MCU) complex (MCUC) function influence dynamics contribute to PAH’s phenotype.Methods: PASMCs were isolated from patients...
Mitotic fission is increased in pulmonary arterial hypertension (PAH), a hyperproliferative, apoptosis-resistant disease. The mediator dynamin-related protein 1 (Drp1) must complex with adaptor proteins to cause fission. Drp1-induced has been therapeutically targeted experimental PAH. Here, we examine the role of 2 recently discovered, poorly understood Drp1 adapter proteins, mitochondrial dynamics 49 and 51 kDa (MiD49 MiD51), normal vascular cells explore their dysregulation PAH.Immunoblots...
Abstract We examined the vulnerability to excitotoxicity of rat oligodendrocytes in dissociated cell culture at different developmental stages. Mature that express myelin basic protein were resistant excitotoxic injury produced by kainate, whereas earlier stages oligodendrocyte lineage vulnerable this insult. To test hypothesis sensitivity immature and resistance mature kainate toxicity due differences membrane responsiveness we used whole‐cell patch‐clamp recording. Oligodendrocyte...
FetA, the recently characterized gonococcal ferric enterobactin receptor, exhibited extremely rapid phase variation between high‐ and low‐expression levels. The frequency of was ≈ 1.3% in both directions strain FA1090. FetA expression ‘high phase’ significantly greater than level ‘low phase’. Expression levels correlated with number cytosine residues a string cytosines located close to transcriptional start site for fetA putative −10 −35 consensus sequences. Antibody production against...
Type 2 diabetes (T2DM) is a growing global health epidemic identified by the World Health Organization (WHO) as major public challenge of 21st century.1 By 2050, it estimated that 1.31 billion people worldwide could be living with T2DM. Across Canada, T2DM affects >9% our population (i.e., >3.6 million individuals), and age-adjusted prevalence also increasing at an alarming rate averaging 3.3% per year. More than 90% have T2DM, most these individuals are cared for in primary care...
BACKGROUND• Alopecia areata (AA) is an autoimmune disease with underlying immunoinflammatory pathogenesis characterized by nonscarring hair loss on the scalp, face, and/or body 1