A5006489468- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Mitochondrial Function and Pathology
- Elasticity and Material Modeling
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- ATP Synthase and ATPases Research
- Composite Material Mechanics
- Numerical methods in engineering
- RNA modifications and cancer
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Nonlocal and gradient elasticity in micro/nano structures
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Connective tissue disorders research
- Cardiomyopathy and Myosin Studies
- Nitric Oxide and Endothelin Effects
- Cardiovascular Effects of Exercise
- Hybrid Renewable Energy Systems
- Composite Structure Analysis and Optimization
- Inflammasome and immune disorders
- Coronary Interventions and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Risk Factors
University of Strathclyde
2021-2024
Queen's University
2015-2024
Glasgow Life
2022
University of Wisconsin–Madison
2012-2015
Madison Area Technical College
2014
Nanjing Forestry University
2012
University of Colorado System
2012
University of Colorado Boulder
2010-2011
Northwestern University
2009
University of British Columbia
2006-2007
The aim of the present study was to determine contemporary survival in pulmonary arterial hypertension (PAH), and investigate whether or not National Institutes Health (NIH) equation remains an accurate predictor survival. In 576 patients with PAH referred during 1991–2007, observed described using Kaplan–Meier method. idiopathic, familial anorexigen-associated (n = 247), versus NIH predicted compared. A new prediction developed exponential regression analysis. 1-, 3- 5-yr total cohort were...
Rationale: Pulmonary arterial hypertension (PAH) often results in death from right ventricular failure (RVF). NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3)-macrophage activation may promote RVF PAH. Objectives: Evaluating the contribution of inflammasome RV macrophages to PAH RVF. Methods: Rats with decompensated hypertrophy (monocrotaline [MCT] and Sugen-5416 hypoxia [SuHx]) were compared compensated rats (pulmonary artery banding)....
Rationale: Pulmonary arterial hypertension (PAH) is an obstructive vasculopathy characterized by excessive pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and apoptosis resistance. This cancer-like phenotype promoted increased cytosolic calcium ([Ca2+]cyto), aerobic glycolysis, mitochondrial fission.Objectives: To determine how changes in uniporter (MCU) complex (MCUC) function influence dynamics contribute to PAH’s phenotype.Methods: PASMCs were isolated from patients...
Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure. While reflects changes the function of resident fibroblasts (RVfib), these cells are understudied. Objective: Examine role mitochondrial metabolism RVfib human and experimental hypertension. Methods Results: Male Sprague-Dawley rats received monocrotaline (MCT; 60 mg/kg) or saline. Drinking water containing no supplement PDK (pyruvate dehydrogenase kinase) inhibitor dichloroacetate was...
Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy. Hereditary cases are associated with germline mutations in BMPR2 and 16 other genes; however, these occur <25% of patients idiopathic PAH rare connective tissue diseases. Preclinical studies suggest epigenetic dysregulation, including altered DNA methylation, promotes PAH. Somatic Tet-methylcytosine-dioxygenase-2 ( TET2 ), key enzyme demethylation, cardiovascular disease clonal hematopoiesis, inflammation, adverse...
Two-dimensional elastic field of a nanoscale circular hole/inhomogeneity in an infinite matrix under arbitrary remote loading and uniform eigenstrain the inhomogeneity is investigated. The Gurtin–Murdoch surface/interface elasticity model applied to take into account stress effects. A closed-form analytical solution obtained by using complex potential function method Muskhelishvili. Selected numerical results are presented investigate size dependency effects surface moduli residual stress....
Pulmonary arterial hypertension (PAH) results in right ventricular (RV) dysfunction and failure. Paradoxically, women are more frequently diagnosed with PAH but have better RV systolic function survival rates than men. The mechanisms by which sex differences alter outcomes remain unknown. Here, we sought to study the role of estrogen functional remodeling response PAH. SU5416-hypoxia (SuHx) mouse model was used. To estrogen, female mice were ovariectomized then treated or placebo. SuHx...
Right ventricular (RV) fibrosis contributes to RV failure in pulmonary arterial hypertension (PAH). The mechanisms underlying PAH and the role of fibroblasts (RVfib) are unknown. Activation mitochondrial fission mediator dynamin-related protein 1 (Drp1) dysfunction myocytes through interaction with its binding partner, (Fis1). However, RVfib is
The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-
Pulmonary arterial hypertension (PAH) is a lethal disease characterized by obstructive pulmonary vascular remodeling and right ventricular (RV) dysfunction. Although RV function predicts outcomes in PAH, mechanisms of dysfunction are poorly understood, RV-targeted therapies lacking. We hypothesized that abnormal microtubular structure cardiomyocytes impairs reducing junctophilin-2 (JPH2) expression, resulting t-tubule derangements. Conversely, we assessed whether colchicine,...
Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression, contributes unrestricted cell proliferation and apoptosis-resistance hyperproliferative diseases like pulmonary arterial hypertension (PAH) non-small lung cancer (NSCLC).We hypothesized that Mfn2 levels are reduced increased proteasomal degradation of triggered by its phosphorylation at serine 442 (S442) investigated the potential kinase mediators.Mfn2 expression was S442 artery smooth muscle cells from...
A new constitutive model for elastic, proximal pulmonary artery tissue is presented here, called the total crimped fiber model. This based on material and microstructural properties of two main, passive, load-bearing components wall, elastin, collagen. Elastin matrix proteins are modeled with an orthotropic neo-Hookean material. High stretch behavior governed by as a planar sinusoidal linear elastic beam, which represents collagen deformations. Collagen-dependent orthotropy defined structure...
Introduction: Group 2 pulmonary hypertension (PH), defined as a mean arterial pressure ≥25 mmHg with elevated capillary wedge >15 mmHg, has no approved therapy and patients often die from right ventricular failure (RVF). Alterations in mitochondrial metabolism, notably impaired glucose oxidation, increased fission, contribute to ventricle (RV) dysfunction PH. We hypothesized that the impairment of RV left (LV) function group PH results part proglycolytic isoform switch pyruvate kinase muscle...
Pulmonary arterial hypertension (PAH), a rapidly fatal vascular disease, strikes women more often than men. Paradoxically, female PAH patients have better prognosis and survival rates males. The sex hormone 17β-estradiol has been linked to the outcome of in females; however, mechanisms by which alters progression outcomes remain unclear. Because proximal pulmonary (PA) stiffness, one hallmark PAH, is powerful predictor mortality morbidity, we hypothesized that attenuates PAH-induced changes...