A5103001104- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Inflammatory mediators and NSAID effects
- Myasthenia Gravis and Thymoma
- Pancreatitis Pathology and Treatment
- Cellular Mechanics and Interactions
- Bone Metabolism and Diseases
- Knee injuries and reconstruction techniques
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic and Hepatic Oncology Research
- Sports injuries and prevention
- Lipoproteins and Cardiovascular Health
- Total Knee Arthroplasty Outcomes
- Platelet Disorders and Treatments
- Muscle Physiology and Disorders
University of Oulu
2019-2024
Oulu University Hospital
2024
Wihuri Research Institute
2021
Helsinki University Hospital
2000
Abstract Collagen XIII is a conserved transmembrane collagen mainly expressed in mesenchymal tissues. Previously, we have shown that modulates tissue development and homeostasis. Integrins are family of receptors mediate signals from the environment into cells vice versa. Integrin α11β1 receptor known to recognize GFOGER (O=hydroxyproline) sequence collagens. Interestingly, integrin both role regulation bone To study whether for XIII, utilized C2C12 transfected express as their only...
Transmembrane collagen XIII has been linked to maturation of the musculoskeletal system. Its absence in mice (Col13a1-/- ) results impaired neuromuscular junction (NMJ) differentiation and function, while transgenic overexpression (Col13a1oe leads abnormally high bone mass. Similarly, loss-of-function mutations COL13A1 humans produce muscle weakness, decreased motor synapse function mild dysmorphic skeletal features. Here, analysis exogenous various muscles revealed highly increased...
Abstract Objectives To study the medial meniscus extrusion (MME) in subjects with and without meniscal tears on magnetic resonance imaging (MRI), supine ultrasound (US), weight‐bearing US. Methods Forty‐seven cases (mean age 43.7 years) 53 healthy controls 36.6 were assessed. Two experienced sonographers performed US evaluations, a fellowship‐trained musculoskeletal radiologist assessed menisci MRI. Independent paired T ‐tests ICC used for statistical analyses. Results On US, mean MME was...
Trypsinogen-2 and the trypsin-2-alpha1-antitrypsin complex are recently introduced new laboratory markers for acute pancreatitis. They show high sensitivity specificity pancreatitis on admission, but little is known their time course profiles.The serum concentrations of trypsinogen-2 were monitored in 92 patients with verified The follow-up period was 42 days severe (N = 73) 9 mild disease 19).On admission mean concentration 2880 microg/l 920 These values 32- 10-fold upper reference limit,...
Mutations in the COL13A1 gene result congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences Col13a1 null mice (Col13a1-/-) recapitulate muscle findings CMS19 patients. Collagen XIII (ColXIII) is exists as two forms, transmembrane protein soluble molecule. While Col13a1-/- have poorly formed junctions, prevention shedding ColXIII ectodomain Col13a1tm/tm...