A5063405173- Osteoarthritis Treatment and Mechanisms
- Innovative Approaches in Technology and Social Development
- E-Learning and Knowledge Management
- Service and Product Innovation
- Total Knee Arthroplasty Outcomes
- Inflammatory mediators and NSAID effects
- Bone and Joint Diseases
- University-Industry-Government Innovation Models
- Recycling and utilization of industrial and municipal waste in materials production
- Bone Metabolism and Diseases
- Periodontal Regeneration and Treatments
- Interprofessional Education and Collaboration
- Interactive and Immersive Displays
- Spectroscopy Techniques in Biomedical and Chemical Research
- Design Education and Practice
- Air Traffic Management and Optimization
- Musculoskeletal synovial abnormalities and treatments
- Innovative Human-Technology Interaction
- Infrared Thermography in Medicine
- Persona Design and Applications
- Research in Social Sciences
- Veterinary Equine Medical Research
- Bauxite Residue and Utilization
- Lower Extremity Biomechanics and Pathologies
- Augmented Reality Applications
University of Oulu
2014-2024
Laurea University of Applied Sciences
2012-2023
University of Johannesburg
2022
Oulu University Hospital
2015-2016
Eurocontrol
2002-2005
Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in structure compared cartilage degeneration. This study linked structural adaptation of with histological OA grade. Twenty-five osteochondral samples macroscopically different degeneration were prepared from tibiae 14 patients. Samples scanned micro-computed tomography (μCT) and both conventional parameters novel 3D based on patterns analyzed the plate...
ObjectiveCollagen distribution within articular cartilage (AC) is typically evaluated from histological sections, e.g., using collagen staining and light microscopy (LM). Unfortunately, all techniques based on sections are time-consuming, destructive, without extraordinary effort, limited to two dimensions. This study investigates whether phosphotungstic acid (PTA) phosphomolybdic (PMA), collagen-specific markers X-ray absorbers, could (1) produce contrast for AC imaging or (2) be used...
This study investigates the influence of osteoarthritis (OA) disease severity on bio-composition osteochondral junction at human tibial plateau using Raman microspectroscopy. We specifically aim to analyze spatial composition mineralized tissues, i.e., calcified cartilage (CC) and subchondral bone plate (SBP) from unfixed, hydrated specimens. hypothesize that mineralization CC SBP decreases in advanced OA. Twenty-eight cylindrical samples (d = 4 mm) plateaus seven cadaveric donors were...
Journal Article SymbolChat: A flexible picture-based communication platform for users with intellectual disabilities Get access Tuuli Keskinen, Keskinen * aUniversity of Tampere, Kanslerinrinne 1, 33014 Finland Corresponding author. Tel.: +358 50 318 5850; fax: 3 219 1001. E-mail addresses:tuuli.keskinen@sis.uta.fi(T. Keskinen), tomi.heimonen@sis.uta.fi (T. Heimonen), markku.turunen@sis.uta.fi (M. Turunen), juha-pekka.rajaniemi@sis.uta.fi (J.-P. Rajaniemi), sami.kauppinen@laurea.fi (S....
Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular cartilage. However, the selectivity PTA staining to cartilage constituents remains be elucidated. The aim this study was investigate dependence content in bovine Adjacent samples were treated chondroitinase ABC and collagenase degrade proteoglycan cartilage, respectively. Enzymatically degraded compared untreated using CEμCT reference...
This article conceptualizes public value and develops a conceptual framework for understanding the nature of in service ecosystems. So far, conceptualization research value, its context ecosystems is incoherent scant. The theoretical development this occurs within foundations ecosystems, service-dominant logic, dominant logic. It bridges domains ecosystem between private sector research. proposes characterizing at different levels ecosystem. main contribution paper further characterization...
Porous alkali-activated materials are synthetic aluminosilicates that should be often produced as granules for practical applications. In the present study, municipal solid waste incineration fly ash with ~1.2 wt% of metallic aluminium was used a novel blowing agent metakaolin (their ratio ranged from 0% to 100%) an aqueous sodium silicate solution alkali-activator and granulation fluid in high-shear granulation. The compressive strength all sufficient (≥2 MPa). Water absorption indicated...
The purpose of the present study was to evaluate bone healing in rabbit critical-sized calvarial defects using two different synthetic scaffold materials, solid biodegradable bioactive glass and tricalcium phosphate granules alongside particulated autogenous grafts.Bilateral full thickness were created 15 New Zealand white adult male rabbits. Ten filled with scaffolds made or porous granules. biomaterial-filled compared at 6 week time point autologous grafted a cranial block 5 combined...
Abstract Tissue paper softness relies on two major factors, the bulk softness, which can be indicated by elasticity of sheet, and surface softness. Measurement is complicated often requires a multi-step process. A key parameter defining topography surface, particularly crepe structure its periodicity. Herein, we present novel approach to measure quantify tissue periodicity based detection waviness along sample using laser scanning confocal microscopy (LSM) X-ray tomography (XRT). In...
Contrast-enhanced micro-computed tomography (CEµCT) with cationic and anionic contrast agents reveals glycosaminoglycan (GAG) content distribution in articular cartilage (AC). The advantage of using stains (e.g. CA4+) compared to Hexabrix®), is that it distributes proportionally GAGs, while stain AC inversely proportional the GAG content. To date, studies have been conducted sufficient resolution study its distributions on macro-scale, but insufficient micro-scale. Therefore, not known...
Citizens' participation in an open innovation process enables them to express their needs and wishes for new kinds of public services. However, the challenge citizens' is finding methods ways working that familiarize participants with complex concepts. Also, make participants' tacit knowledge visible. Design games aim at creating a forum meeting users designers as well providing tools making empirical This paper introduces WeLive design game aims help co-design workshops innovate develop...
To characterize inflammatory and mechanical changes in the collagenase-induced OA (CIOA) model rats.
Mutations in the COL13A1 gene result congenital myasthenic syndrome type 19 (CMS19), a disease of neuromuscular synapses and including various skeletal manifestations, particularly facial dysmorphisms. The phenotypic consequences Col13a1 null mice (Col13a1-/-) recapitulate muscle findings CMS19 patients. Collagen XIII (ColXIII) is exists as two forms, transmembrane protein soluble molecule. While Col13a1-/- have poorly formed junctions, prevention shedding ColXIII ectodomain Col13a1tm/tm...
Technological development has significantly affected children's everyday life over the last decades. Interactive technologies have become an inseparable part of their daily lives. In this paper, we present results a case study product designs that aims to provide new opportunities for children enjoy traditional storybook, more interactive fashion. Also, aim was increase understanding about full-body gesture technology when users are young children. The initial prototype Kinetic Stories...
The European ATC Harmonization and Integration Programme, EATCHIP, is a phased programme, where phases I II dealt with assessment of the current situation setting goals for programme run by EUROCONTROL Agency on behalf 35 Member States Civil Aviation Conference. EATCHIP Phase III first harmonized acquisition implementation phase. IV will include very advanced ATM automation up to year 2015 (and beyond). This paper gives background information detection conflicts in timeframe Europe brief...
Packaging forms a large share of the total manufacturing costs optoelectronic modules. This especially concerns techniques, where active optical power monitoring is required during assembly components. Passive alignment offers advantages for high volume manufacturing. However, high-performance modules require high-precision structures. We studied methods horizontal structures using low temperature co-fired ceramic (LTCC) technology. In this paper, we present manufacture LTCC test parts and...
The medium-term conflict detection (MTCD) field trials are an important part of EUROCONTROL's performance enhancement programme for European ATM (EATMP), which consists 22 (sub)-programmes. One them, automated support to air traffic services (ASA) 2, develops, prototypes, simulates and finally tests in live ATC environment new decision tools. ASA is developing solutions challenges, such as complexity management, sequencing metering, resolution. main principle layered planning; where complex...
FORMING MULTIDISCIPLINARY MASTER’S DEGREE STUDENT TEAMS BY MEANS OF GAMIFICATION CASE: THE WELIVE DESIGN GAME