A5024070927- Osteoarthritis Treatment and Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Infrared Thermography in Medicine
- Spectroscopy and Chemometric Analyses
- Veterinary Equine Medical Research
- Total Knee Arthroplasty Outcomes
- Rheumatoid Arthritis Research and Therapies
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Meat and Animal Product Quality
- Advanced MRI Techniques and Applications
- Veterinary Orthopedics and Neurology
- Bone health and osteoporosis research
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Bone and Joint Diseases
- SARS-CoV-2 and COVID-19 Research
- Advanced Chemical Sensor Technologies
- Silk-based biomaterials and applications
- Tendon Structure and Treatment
- Collagen: Extraction and Characterization
- Diabetic Foot Ulcer Assessment and Management
- Advanced Neuroimaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Inflammatory mediators and NSAID effects
University of Oulu
2011-2024
Polar (Finland)
2024
University of Eastern Finland
2009-2019
Finland University
2012-2019
Oulu University Hospital
2016-2018
Kuopio University Hospital
2011-2017
N-methyl-2-pyrrolidone (NMP) is the most common solvent for manufacturing cathode electrodes in battery industry; however, it becoming restricted several countries due to its negative environmental impact. Taking into account that ∼99% of used during electrode fabrication recovered, dimethylformamide (DMF) a considerable candidate replace NMP. The lower boiling point and higher ignition temperature DMF lead significant reduction energy consumption needed drying improve safety production...
In highly organized tissues, such as cartilage, tendons and white matter, several quantitative MRI parameters exhibit dependence on the orientation of tissue constituents with respect to main imaging magnetic field (B
Articular cartilage (AC) is mainly composed of water, type II collagen, proteoglycans (PGs) and chondrocytes. The amount PGs in AC routinely quantified with digital densitometry (DD) from Safranin O-stained sections, but it unclear whether similar method could be used for collagens.The aim this study was to clarify collagens can histological sections using DD.Sixteen human samples were stained Masson's trichrome or Picrosirius red. Optical densities stains compared two commonly collagen...
Type 2 diabetes mellitus (T2DM) is a major risk factor for heart disease. Mortality rates after myocardial infarction (MI) are significantly increased in T2DM patients because of dysfunctional left ventricle (LV). However, molecular pathways underlying accelerated failure (HF) MI remain unclear. We investigated the mechanisms by inducing well-established model and control mice. Cardiac imaging revealed decreased global ventricular ejection fraction parallel with mortality mice compared...
Renal osteodystrophy alters metabolic activity and remodeling rate of bone also may lead to different composition. The objective this study was characterize the composition in high-turnover renal patients by means Fourier transform infrared spectroscopic imaging (FTIRI). Iliac crest biopsies from healthy (n = 11) with (ROD, n were used study. ROD samples hyperparathyroid disease. By using FTIRI, phosphate-to-amide I ratio (mineral-to-matrix ratio), carbonate-to-phosphate ratio,...
The molecular composition of the organic and inorganic matrices bone undergoes alterations during maturation. aim this study was to compare Fourier transform infrared (FT-IR) near-infrared (NIR) Raman microspectroscopy techniques for characterization growing developing from young skeletally mature rabbits. Moreover, specificity differences determining were clarified. humeri female New Zealand White rabbits, with age range animals (four groups, n = 7 per group), studied. Spectral peak areas,...
Articular cartilage is a connective tissue that located at the ends of long bones. Type II collagen, proteoglycans, water, and chondrocytes are main constituents articular cartilage. Osteoarthritis, most common joint disease in world, causes degenerative changes tissue. Fourier transform infrared, Raman, near infrared spectroscopic techniques offer versatile tools to assess biochemical composition quality These vibrational can be used broaden our understanding about compositional during...
This study investigates the influence of osteoarthritis (OA) disease severity on bio-composition osteochondral junction at human tibial plateau using Raman microspectroscopy. We specifically aim to analyze spatial composition mineralized tissues, i.e., calcified cartilage (CC) and subchondral bone plate (SBP) from unfixed, hydrated specimens. hypothesize that mineralization CC SBP decreases in advanced OA. Twenty-eight cylindrical samples (d = 4 mm) plateaus seven cadaveric donors were...
Abstract 2D transition‐metal carbides (Ti 3 C 2 T x MXene) intercalated with organic molecules have been widely used in batteries and supercapacitors, but are quite rarely reported for gas sensing. Since Ti is sensitive to oxygen, most methods preparing the involve stirring reactants several hours under nitrogen protection. Herein, a method prepare hybrid of polysquaraine through microwave‐assisted situ polymerization that takes only few minutes without need using protective atmosphere...
Articular cartilage undergoes structural and biochemical changes during maturation, but the knowledge on how these relate to articular function at different stages of maturation is lacking. Equine samples four levels (newborn, 5-month-old, 11-month-old adult) were collected (N = 25). Biomechanical tensile testing, Fourier transform infrared microspectroscopy (FTIR-MS) polarized light microscopy used study tensile, properties cartilage, respectively. The modulus was highest breaking energy...
Abstract Objective: To evaluate the specificity of current Fourier transform infrared imaging spectroscopy (FT‐IRIS) methods for determination depthwise proteoglycan (PG) content in articular cartilage (AC). In addition, curve fitting was applied to study whether FT‐IRIS parameters PG could be improved. Methods: Two sample groups from steer AC were prepared ( n = 8 samples/group). first group, chondroitinase ABC enzyme used degrade PGs superficial cartilage, while samples second group served...
Fourier Transform Infrared (FT-IR) spectroscopic imaging has been earlier applied for the spatial estimation of collagen and proteoglycan (PG) contents articular cartilage (AC). However, studies have limited to use univariate analysis techniques. Current methods lack needed specificity PGs. The aim present study was evaluate suitability partial least squares regression (PLSR) principal component (PCR) PG content AC. Multivariate models were compared with used tested a sample material...
Abstract On-chip energy storage and management will have transformative impacts in developing advanced electronic platforms with built-in needs for operation of integrated circuits driving a microprocessor. Though success growing stand-alone elements such as electrochemical capacitors (super pseusocapacitors) on variety substrates is promising step towards this direction. In work, on-chip demonstrated using architectures highly aligned vertical carbon nanotubes (CNTs) acting supercapacitors,...
Contrast-enhanced micro-computed tomography (CEμCT) with phosphotungstic acid (PTA) has shown potential for detecting collagen distribution of articular cartilage. However, the selectivity PTA staining to cartilage constituents remains be elucidated. The aim this study was investigate dependence content in bovine Adjacent samples were treated chondroitinase ABC and collagenase degrade proteoglycan cartilage, respectively. Enzymatically degraded compared untreated using CEμCT reference...
Abstract The changes in chemical composition of human articular cartilage (AC) caused by osteoarthritis (OA) were investigated using Fourier transform infrared microspectroscopy (FTIR-MS). We demonstrate the sensitivity FTIR-MS for monitoring compositional that occur with OA progression. Twenty-eight AC samples from tibial plateaus imaged FTIR-MS. Hyperspectral images all combined K-means clustering. Partial least squares regression (PLSR) analysis was used to compare spectra OARSI grade...
Saliva provides a valuable tool for assessing oral and systemic diseases, but concentrations of salivary components are very small, calling the need precise analysis methods. In this work, Fourier transform infrared (FT-IR) spectroscopy using transmission photoacoustic (PA) modes were compared quantitative saliva. The performance these techniques was with calibration series. linearity spectrum output verified by albumin–thiocyanate (SCN – ) solution at different SCN concentrations. samples...
Articular cartilage composition and structure are maintained remodeled by chondrocytes under the influence of loading. Exercise-induced changes in composition, structure, mechanical properties tissue integrity growing aging hamster articular were investigated. samples (n = 191) harvested from proximal tibiae hamsters aged 1, 3, 6, 12 15 months. The divided into runners controls. had free access to a running wheel between 1 3 months (runner groups 3-, 12- 15-month-old hamsters) or 6 group...
Abstract Raman spectroscopy is promising in vivo tool various biomedical applications; moreover, recent years, its use for characterizing articular cartilage degeneration has been developing. It also shown potential scoring the severity of lesions, which could be useful determining optimal treatment strategy during repair surgery. However, effect different injury types on spectra unknown. This study aims to investigate detecting changes due types. Artificial injuries were induced samples...