A5015775773- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- High-pressure geophysics and materials
- Collagen: Extraction and Characterization
- Food composition and properties
- Geological and Geochemical Analysis
- Advanced X-ray and CT Imaging
- Knee injuries and reconstruction techniques
- Isotope Analysis in Ecology
- X-ray Diffraction in Crystallography
- earthquake and tectonic studies
- Photoacoustic and Ultrasonic Imaging
- Infrared Thermography in Medicine
- Marine and fisheries research
- Bone and Joint Diseases
- Hip disorders and treatments
- Fish Ecology and Management Studies
- Periodontal Regeneration and Treatments
- Polysaccharides Composition and Applications
- Phytase and its Applications
- Nuclear physics research studies
- Phase-change materials and chalcogenides
- Diabetic Foot Ulcer Assessment and Management
- Astronomical and nuclear sciences
University of Jyväskylä
2023
South Karelia Central Hospital
2016-2017
University of Eastern Finland
2009-2016
Kuopio University Hospital
2011-2016
Australian National University
2007-2014
Finland University
2012
The aim of this study was to investigate the feasibility delayed cone beam (CBCT) arthrography for clinical diagnostics knee cartilage lesions. Knee joints with lesions were imaged using native radiography, MRI, and CBCT techniques in vivo. three times CBCT, just before, immediately after (arthrography) 45 min intra-articular injection contrast agent. arthrographic images enabled sensitive detection Use together their subtraction image also inferior integrity. agent partition intact (ICRS...
New crystalline structures have been observed in argon ion-milled conodont elements from a diverse suite of Ordovician taxa (‘Cordylodus robustus’, Drepanoistodus suberectus, Panderodus gracilis, Plectodina? sp., Aphelognathus Periodon aculeatus), using transmission electron microscopy (TEM). Electron diffraction patterns albid tissue reveal that the component crystals are extraordinarily large, order hundred(s) microns. These large show typical cancellate porosity, although distinctly...
Charged contrast agents have been used both in vitro and vivo for estimation of the fixed charge density (FCD) articular cartilage. In present study, effects molecular size on diffusion equilibrium distribution several magnetic resonance imaging (MRI) computed tomography (CT) were investigated. Full thickness cartilage disks (Ø = 4.0 mm, n 64) prepared from fresh bovine patellae. Contrast agent (gadopentetate: Magnevist((R)), gadodiamide: Omniscan, ioxaglate: Hexabrix or sodium iodide: NaI)...
The viscoelasticity of mildly impure polycrystalline iron has been studied over the temperature range 20–1300°C through a combination seismic‐frequency torsional forced oscillation and microcreep tests. For all temperatures above ∼400°C, linear absorption band behavior is observed, both strain energy dissipation Q −1 shear modulus dispersion providing evidence substantial departures from ideal elastic behavior. 3 s period sensitivity |∂ G /∂ T averages 0.04 GPa K . An even larger derivative...
We have prepared GexAsySe1−x−y glasses with mean coordination numbers (MCNs) from 2.2 to 2.86. Tg was found generally increase increasing MCN while the glass density showed a maximum at MCN≈2.45 and minimum MCN≈2.65. The elastic moduli of were estimated shear compressional wave velocities measured by ultrasonic pulse interferometry. For first time we simultaneously observed two transition thresholds, second MCN≈2.65, which appear closely correlated changes in microstructure. groups samples...
We investigated the feasibility of delayed computed tomography (CT) arthrography for evaluation human knee cartilage in vivo. Especially, diffusion contrast agent out joint space and optimal time points imaging were determined.Two patients imaged using CT gadolinium-enhanced magnetic resonance (dGEMRIC) techniques.Two hours after injection, concentration was still high enough (20% to 24.5% initial at 0 minutes) allow arthrography. The half-life varied from 30 60 minutes. patellar femoral...
Osteoarthritis causes changes in the subchondral bone structure and composition. Plain radiography is a cheap, fast, widely available imaging method. Bone tissue can be well seen from plain radiograph, which however only 2D projection of actual 3D structure. Therefore, aim was to investigate relationship between density- structure-related parameters radiograph assessed micro computed tomography (µCT) ex vivo. Right tibiae eleven cadavers without any diagnosed joint disease were imaged using...
Objective The aim of this study was to investigate whether the concentration anionic contrast agent ioxaglate, as quantitated by contrast-enhanced computed tomography (CECT) using a clinical cone-beam CT (CBCT) instrument, reflects biochemical, histological, and biomechanical characteristics articular cartilage imaged in an ex vivo, intact human knee joint. Design An osteoarthritic cadaveric joint (91 years old) injected with ioxaglate (36 mg I/mL) CBCT over 61 hours diffusion into...
Contrast agent enhanced cone beam computed tomography (CE-CBCT), a technique capable of high-resolution in vivo imaging with small radiation dose, has been applied successfully for clinical diagnostics cartilage degeneration, i.e., osteoarthritis (OA). As an X-ray technique, CE-CBCT may also detect changes mineral density subchondral bone (volumetric density, vBMD), known to be characteristic OA. However, its feasibility measurements is not clear due limited signal-to-noise ratio and...
The $\ensuremath{\alpha}$ decay of a new isotope $^{190}\mathrm{At}$ has been studied via the $^{109}\mathrm{Ag}(^{84}\mathrm{Sr},3\mathrm{n})^{190}\mathrm{At}$ fusion-evaporation reaction by employing gas-filled recoil separator. An $\ensuremath{\alpha}$-particle energy 7750(20) keV and half-life $1.{0}_{\ensuremath{-}0.4}^{+1.4}$ ms were measured. measured properties correspond to an unhindered decay, suggesting same spin parity (${10}^{\ensuremath{-}}$) as those final state decay....
Extensive collagen cross-linking affects the mechanical competence of articular cartilage: it can make cartilage stiffer and more brittle. The concentrations best known cross-links, pyridinoline pentosidine, be accurately determined by destructive high-performance liquid chromatography (HPLC). We explore a nondestructive evaluation using intrinsic fluorescence intact cartilage. Articular samples from bovine knee joints were incubated in threose solution for 40 100 h to increase...
Abstract A slip-system analysis was performed on two synthetic compressively deformed olivine aggregates, derived from experimental solution–gelation (sol–gel) and natural San Carlos precursors to determine how dislocation density relates Schmid factor for slip in olivine. Individual grain orientations were measured with electron backscatter diffraction. Using decorated dislocations, populations separated into subsets of high versus low density. Analysis preferred distributions factors...
SUMMARY Contrast enhanced computer tomography (CT) imaging of articular cartilage has been proposed for diagnostics degeneration, that is, osteoarthritis. Previous studies also indicate acute damage can be detected by measuring diffusion contrast agent into using CT. However, currently, there is no reliable method to measure spatial rates within tissue, and only average bulk values have reported. In this paper, we develop a determine depthwise diffusivity agents in tissue The triphasic...
Collagen forms an organized network in articular cartilage to give tensile stiffness the tissue. Due its long half-life, collagen is susceptible cross-links caused by advanced glycation end-products. The current standard method for determination of cross-link concentrations tissues destructive high-performance liquid chromatography (HPLC). aim this study was analyze nondestructively from unstained histological sections using Fourier transform infrared (FTIR) microspectroscopy. Half bovine...