A5058496097- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Electron Spin Resonance Studies
- RNA modifications and cancer
- Lymphatic System and Diseases
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Cardiac pacing and defibrillation studies
- Cholesterol and Lipid Metabolism
- Prostate Cancer Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Ultrasound and Hyperthermia Applications
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Cardiac Structural Anomalies and Repair
- Coronary Interventions and Diagnostics
- Angiogenesis and VEGF in Cancer
Finland University
2024
University of Eastern Finland
2012-2024
Kuopio University Hospital
2017-2024
Institute for Molecular Science
2024
Imaging Center
2024
Institute for Molecular Medicine Finland
2019
Type 2 diabetes mellitus (T2DM) is a major risk factor for heart disease. Mortality rates after myocardial infarction (MI) are significantly increased in T2DM patients because of dysfunctional left ventricle (LV). However, molecular pathways underlying accelerated failure (HF) MI remain unclear. We investigated the mechanisms by inducing well-established model and control mice. Cardiac imaging revealed decreased global ventricular ejection fraction parallel with mortality mice compared...
Heart has a wide lymphatic network but the importance of cardiac system in heart diseases remained unclear. Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) is key molecule development and maintenance vessels. Here we characterized role VEGFR3 healthy hearts after myocardial infarction (MI) by using sVEGFR3 transgenic mice expressing soluble decoy under K14 promoter Chy which have an inactivating mutation gene. Cardiac vessels were significantly dilated when compared to controls....
Abstract Longitudinal relaxation time in the rotating frame ( T 1 ρ ) was measured using continuous wave irradiation normal and infarcted mouse myocardium vivo. Significant increase found after 7 days of infarction when compared with reference or before infarction. Cine MRI histology were performed to verify severity The course infarct fits better granulation scar tissue formation than necrosis edema. results study show that could potentially be a noninvasive quantitative marker for...
The 9p21.3 genomic locus is a hot spot for disease-associated single-nucleotide polymorphisms (SNPs), and its strongest associations are with coronary artery disease (CAD). SNPs located within the sequence of long noncoding RNA ANRIL, which potentially contributes to atherogenesis by regulating vascular cell stress proliferation, but also affects pancreatic β-cell proliferation. Altered expression neighboring gene, CDKN2B, has been recognized correlate obesity hepatic steatosis in people...
Two days after myocardial infarction (MI), the infarct consists mostly on necrotic tissue, and myocardium is transformed through granulation tissue to scar in two weeks onset of ischemia mice. In current work, we determined optimized cardiovascular magnetic resonance (CMR) methods for detection MI size during formation without contrast agents We characterized remote areas with rotating frame relaxation time mapping including along fictitious field nth (RAFFn), T1ρ T2 mappings at 1, 3, 7, 21...
To compare 4D flow magnetic resonance imaging (MRI) and 2D phase contrast (PC) MRI when evaluating bicuspid (BAV) tricuspid (TAV) aortic valves.A total of 83 subjects (35 BAV, 48 TAV) were explored with PC MRI. Systolic peak velocity, regurgitation fraction analysed at two pre-defined levels (aortic root, mid-tubular). Furthermore, the methods analysis (Heart Artery) compared.Correlation between derived parameters ranged from moderate (R=0.58) to high (R=0.90). yielded significantly higher...
Abstract The role of cardiac lymphatics in the pathogenesis myocardial infarction (MI) is unclear. Lymphatic system regulates physiological processes such as edema and tissue fluid balance, which affect MI pathogenesis. Recently, fibrosis have been assessed using endogenous contrast magnetic resonance imaging (MRI) based on relaxation along a fictitious field with rank n (RAFFn). We extended RAFFn applications to evaluate effects lymphatic insufficiency comparison longitudinal rotating frame...
Cardiovascular diseases are the leading cause of deaths worldwide. Many complex cellular and molecular pathways lead to myocardial remodeling after ischemic insults. Anatomy, function, viability myocardium can be assessed by modern medical imaging techniques both visualizing quantifying damages. Novel aim for a precise accurate visualization detection alternations at level. Magnetic resonance assesses anatomy, tissue characterization non-invasively with high spatial resolution, sensitivity,...
Aims In calcific aortic valve disease (CAVD), progressive valvular sclerosis and calcification cause narrowing of the orifice an impairment valve's function. We applied high‐resolution cine‐MRI to perform quantitative analysis dynamics in a mice model CAVD. Methods Results LDLr −/− ApoB 100/100 were fed Western diet (WD) or standard (control) for 22 weeks. The imaged 7 T horizontal MRI scanner, was examined by imaging cross‐section aorta at level using cine sequences. From these images, area...
Background Vascular endothelial growth factors (VEGFs) are major regulators of intratumoral angiogenesis in ovarian cancer (OVCA). Overexpression VEGFs is associated with increased tumor and metastatic tendency VEGF-targeting therapies thus considered as potential treatments for OVCA. Here, we examined the antiangiogenic antitumoral effects on OVCA adeno-associated virus 8 (AAV8)-mediated expression soluble VEGF receptors (sVEGFRs) sVEGFR2 sVEGFR3 together paclitaxel carboplatin...
Abstract OBJECTIVES The objective of this study was primarily to compare four-dimensional flow magnetic resonance imaging metrics in the ascending aorta (AA) patients with right–left fusion type bicuspid aortic valve (RL-BAV) and repaired coarctation (CoA) RL-BAV without CoA. Metrics were also compared matched group common tricuspid (TAV). METHODS Eleven CoA, 11 CoA 22 controls TAV investigated. Peak velocity (cm/s), peak (ml/s) displacement (%) analysed at 5 pre-defined AA levels. In...
<title>Abstract</title> Background Cardiovascular diseases are the leading cause of death worldwide due to population growth and aging. Myocardial infarction is one most crucial cardiovascular diseases. Acute myocardial conventionally imaged with T<sub>2</sub> mapping its sensitivity related correlation times edema free-water molecules. Chronic infarction, which contains fibrosis scar tissue, MRI T<sub>1</sub> weighting using contrast agents involved in late gadolinium enhancement...
Abstract Introduction Myocardial ischemia-reperfusion injury (IRI) occurs after myocardial infarction when reperfusion aggravates the initial damage in myocardium by vast infiltration of inflammatory cells and elevated oxidative stress that may lead to cardiac remodeling, heart failure even death [1]. Magnetic resonance imaging (MRI) can accurately determine anatomy characterize tissue. Novel endogenous rotating frame MRI methods, including continuous wave (CW) T1r relaxation along a...
Motivation: Conventional CMR techniques have many limitations, such as slowness and inability to provide contrast-agent free 3-D assessments of myocardium in the cardiac diseases. Goal(s): The aim this study is develop a faster, high-resolution imaging method for quantitative after myocardial infarction (MI). Approach: Mice hearts were imaged ex vivo 7 days factitious MI by using an ultra-short echo time T1&rho; technique (MB-SWIFT-CS). Results: relaxation times elevated infarct area....
Motivation: Current MRI techniques are insufficiently sensitive to determine specific physiological changes in the myocardium after infarction. Goal(s): To optimize sensitivity of RAFF2 technique tissue myocardial infarct (MI) by modulating durations P-packets pulses. Approach: Mice hearts imaged ex vivo 7 days factitious infarction using different along with other rotating frame relaxation techniques. Results: Duration pulse have an impact on maps and contrast MI area compared remote area....
Abstract Aims The aim of this study was to develop an ultra-short echo time 3D magnetic resonance imaging (MRI) method for subacute myocardial infarction (MI) quantitatively and in accelerated way. Here, we present novel T1- T1ρ-weighted Multi-Band SWeep Imaging with Fourier Transform Compressed Sensing (MB-SWIFT-CS) MI mice hearts ex vivo. Methods results Relaxation time–weighted under-sampled MB-SWIFT-CS MRI were tested manganese chloride (MnCl2) phantom model. induced C57BL mice, the...
The identification of areas with regenerative potential in ischemic tissues would allow the targeting treatments supporting tissue recovery. regeneration process involves activation several cellular and molecular responses which could be detected using magnetic resonance imaging (MRI). However, to date, (MR) relaxation parameters have received little attention diagnosis follow‐up limb ischemia. purpose this study was evaluate feasibility different MRI diffusion tensor detection showing early...
Purpose of this review: Cardiovascular Diseases (CVD) are the leading cause deaths worldwide. Myocardial Infarction (MI) is one deadliest CVDs. MI causing many complex cellular biological changes in myocardium after myocardial infarction (MI). Modern magnetic resonance imaging (MRI) techniques, such as rotating frame relaxation time T1ρ, can be used to visualize and quantify damages and for detection alternations without use contrast agents. However, T1ρ method suffers from high...
MRI is a common method of prostate cancer diagnosis. Several MRI‐derived markers, including the apparent diffusion coefficient (ADC) based on diffusion‐weighted imaging, have been shown to provide values for detection and characterization. The hypothesis study was that docetaxel chemotherapy response could be picked up earlier with rotating frame relaxation times T RAFF2 RAFF4 than continuous wave 1ρ , adiabatic 2ρ 1 2 or water ADC. Human PC3 cells expressing red fluorescent protein were...
Abstract Introduction Cardiac magnetic resonance (CMR) is important tool for assessment of structure and function the myocardium in various cardiac conditions, such as after myocardial infarction (MI). CMR methods rely solely on multi-slice 2-D imaging, which tends to be slow, since every slice imaged separately with &gt;3 min scan time. Furthermore, are somewhat approximate, due thickness, usually around 1 mm mice 8 humans. Therefore, 3-D imaging isotropic resolution urgently needed. In...
Abstract Introduction The role of cardiac lymphatic system in myocardial infarction (MI) is still unclear. A new method to detect and characterize MI without contrast agent a relaxation along fictitious field nth rotating frame (RAFFn). RAFFn takes advantage the magnetic field, which produced by fast sweep an effective radio frequency increase spin locking strength increasing specific absorption rate. detected as increased times edema T2 time. We have shown earlier that size can be...