A5083544853- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Effects and risks of endocrine disrupting chemicals
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Neurogenesis and neuroplasticity mechanisms
Leibniz Institute of Environmental Medicine
2021-2025
There is a call for paradigm shift in developmental neurotoxicity (DNT) evaluation, which demands the implementation of faster, more cost-efficient, and human-relevant test systems than current vivo guideline studies. Under umbrella Organisation Economic Co-operation Development (OECD), guidance document currently being prepared that instructs on regulatory use DNT vitro battery (DNT IVB) fit-for-purpose applications. One crucial issue OECD application methods validation, new approach (NAMs)...
Despite growing awareness of endocrine disrupting chemicals (EDCs), knowledge gaps remain regarding their effects on human brain development. EDC risk assessment focuses primarily EATS modalities (estrogens, androgens, thyroid hormones, and steroidogenesis), overlooking the broader range hormone receptors expressed in developing brain. This limits evaluation for potential to cause disruption-mediated developmental neurotoxicity (ED-DNT). The Neurosphere Assay, an vitro test method (DNT)...