A5083747370- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Genetic factors in colorectal cancer
- Management of metastatic bone disease
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Neuroendocrine Tumor Research Advances
- Melanoma and MAPK Pathways
- Breast Lesions and Carcinomas
- Cancer Mechanisms and Therapy
- Science, Research, and Medicine
- Advanced Breast Cancer Therapies
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- Radiomics and Machine Learning in Medical Imaging
- Angiogenesis and VEGF in Cancer
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
Queen's University
2013-2024
Kingston Health Sciences Centre
2023
Kingston General Hospital
2015-2018
UCSF Helen Diller Family Comprehensive Cancer Center
2016
University of California, San Francisco
2016
Manitoba Health
2016
Cancer Care South East
2013-2015
London Health Sciences Centre
2013-2014
Institute of Cancer Research
1992-2013
Cancer Care Ontario
2013
Background: Grade-III invasive ductal carcinomas of no special type (IDCs-NST) constitute a heterogeneous group tumours with different clinical behaviour and response to chemotherapy. As many as 25% all grade-III IDCs-NST are known harbour basal-like phenotype, defined by gene expression profiling or immunohistochemistry for basal cytokeratins. Patients breast (BLBC) reported have shorter disease-free overall survival. Material methods: A retrospective analysis 49 patients BLBC (as...
The protein kinase gene LKB1 has recently been identified as the mutated in Peutz-Jeghers cancer predisposition syndrome. This condition is characterized by inherited susceptibility to a range of cancers but particular those gastrointestinal tract. Here we have mouse Lkbl gene. consists 10 exons covering ∼15 kb length, maps chromosome and encodes showing strong sequence similarity human LKB1. 3′ end Lkb1 very close proximity an apparently unrelated R29144/1 it seems probable that overlapping...
Timely lung cancer care has been associated with improved clinical outcomes and patient satisfaction. We identified improvement opportunities in management pathways at Kingston Health Sciences Centre. Quality strategies led to the implementation of a multidisciplinary clinic (MDC).We set an outcome measure decreasing time from diagnosis first treatment by 10 days within 6 months implementation. implemented weekly MDC that involved respirologists, medical oncologists, radiation oncologists...
Despite evidence for the superiority of twice-daily (BID) radiotherapy schedules, their utilization in practice remains logistically challenging. Hypofractionation (HFRT) is a commonly implemented alternative. We aim to compare outcomes and toxicities limited-stage small-cell lung cancer (LS-SCLC) patients treated with hypofractionated versus BID schedules. A bi-institutional retrospective cohort review was conducted LS-SCLC (45 Gy/30 fractions) or HFRT (40 Gy/15 schedules from 2007 2019....
Stage iii lung cancer is the most advanced stage of for which potential curative treatment often discussed. However, a large proportion patients are treated with palliative intent. An understanding time-dependent and -independent factors contributing to choice palliative-intent needed help optimize patient outcomes.This retrospective cohort study non-small-cell (nsclc) newly diagnosed between 1 January 2008 31 December 2012 at Cancer Centre Southeastern Ontario collected data including...
Stage iii lung cancer is the most advanced stage of for which radical (potentially curative) treatment often discussed. Understanding reasons mortality and subsequent treatments in patients with non-small-cell (nsclc) important.This retrospective cohort study extracted demographic, clinical, treatment, outcomes data newly diagnosed nsclc between 1 January 2008 31 December 2012 at a single institution.The included 237 nsclc, 130 whom were not treated or curative intent (55%). Median survival...
<h3>Introduction</h3> Surgical resection is a treatment of choice for patients with early stage lung cancer and physiological measurements are routinely used to help predict post-operative risk, particularly in the ‘high-risk’ patient group. At present, there lack concordance between current available guidelines incorporating use such parameters aimed guide decisions on surgery high-risk cancer. As result, decision operate will differ particular depending which consulted. We aim identify...
5065 Background: Loss of function PTEN is the most common genetic defect in endometroid endometrial carcinomas (EEC). plays a pivotal role regulation AKT and mTOR signalling pathways reported to be inactivated up 80% EECs. loss has recently been shown cause instability through defects homologous recombination (HR) DNA repair double strand breaks. Cancer cells with defective HR have an exquisite sensitivity inhibitors poly(ADP) ribose polymerase (PARP) inhibitors. Recent data suggest...