A5032349111- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Macrophage Migration Inhibitory Factor
- Peptidase Inhibition and Analysis
- Contact Dermatitis and Allergies
- Galectins and Cancer Biology
- Food Allergy and Anaphylaxis Research
- Rheumatoid Arthritis Research and Therapies
- Eosinophilic Esophagitis
University of Campania "Luigi Vanvitelli"
2023
Sapienza University of Rome
2016-2018
The Endoplasmatic Reticulum Aminopeptidases ERAP1 and ERAP2 are implicated in a variety of immune non-immune functions. Most studies however have focused on their role shaping the HLA class I peptidome by trimming peptides to optimal size. Genome Wide Association Studies highlighted non-synonymous polymorphisms coding regions as associated with several mediated diseases. two genes lie contiguous oppositely oriented 5q15 chromosomal region. Very little is known about transcriptional...
Food allergy is common in the Mediterranean, especially concerning lipid transfer proteins (LTPs) allergy. LTPs are widespread plant food allergens fruits, vegetables, nuts, pollen, and latex. Also, prevalent Mediterranean area. They can sensitize via gastrointestinal tract cause a wide range of conditions: from mild reactions, such as oral syndrome, to severe anaphylaxis. LTP adult population well described literature, both prevalence clinical characteristics. However, there poor knowledge...
Abstract The HLA‐B*27 peptidome has drawn significant attention due to the genetic association between some of alleles and inflammatory rheumatic disease ankylosing spondylitis (AS), for which a comprehensive biological explanation is still lacking. This study aims expand known limits facilitate selection testing new peptides, possibly involved in disease. HLA peptidomes HeLa C1R cell lines stably transfected with AS‐associated HLA‐B*27:05 allele, nonassociated HLA‐B*27:09 or their cysteine...
HLA-B*27 is strongly associated with an inflammatory autoimmune disorder, the Ankylosing Spondylitis (AS) and plays a protective role in viral infections. The two aspects might be linked. In this work, we compared B*2705/B*07 positive patients AS, CD8+ T cell responses to immunodominant EBV-derived epitopes restricted for either (pEBNA3C) or HLA-B*07 (pEBNA3A). We have unexpectedly found that HLA-B*07-restricted EBNA3A peptide presented by both B*0702 B*2705 but not non AS-associated B*2709,...