A5020590960- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Glioma Diagnosis and Treatment
- Liver Disease and Transplantation
- Family Support in Illness
- Lymphoma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Mental Health and Patient Involvement
- Exercise and Physiological Responses
- Rheumatoid Arthritis Research and Therapies
- Advanced biosensing and bioanalysis techniques
- Antenna Design and Analysis
- Pharmaceutical studies and practices
- Quinazolinone synthesis and applications
- RNA modifications and cancer
- Full-Duplex Wireless Communications
- Cancer Treatment and Pharmacology
- Dermatology and Skin Diseases
- Immune cells in cancer
- Drug-Induced Hepatotoxicity and Protection
- Educational and Social Studies
- Molecular Communication and Nanonetworks
- Cardiac Imaging and Diagnostics
- Palliative Care and End-of-Life Issues
- Acute Lymphoblastic Leukemia research
Essen University Hospital
2024
German Cancer Research Center
2024
Heidelberg University
2024
University of Duisburg-Essen
2024
Deutschen Konsortium für Translationale Krebsforschung
2024
Ospedale Antonio Cardarelli
2015
Istituto Euro Mediterraneo di Scienza e Tecnologia
2014
Meteorin-like protein (METRNL)/Interleukin-41 (IL-41) is a novel immune-secreted cytokine/myokine involved in several inflammatory diseases. However, how METRNL exerts its regulatory properties on skin inflammation remains elusive. This study aims to elucidate the functionality and mechanism of atopic dermatitis (AD). levels were determined serum samples from patients with AD subsequently verified vitamin D3 analogue MC903-induced AD-like mice model. The cellular target activity was...
Abstract 5q-associated spinal muscular atrophy (SMA) is a motoneuron disease caused by mutations in the survival motor neuron 1 (SMN1) gene. Adaptive immunity may contribute to SMA as described other diseases, yet mechanisms remain elusive. Nusinersen, an antisense treatment, enhances SMN2 expression, benefiting patients. Here we have longitudinally investigated and nusinersen effects on local immune responses cerebrospinal fluid (CSF) - surrogate of central nervous system parenchyma....
DNA replication is essential to life and ensures the accurate transmission of genetic information, which significantly disturbed during cancer development chemotherapy. While tightly controlled in time space, methods visualise quantify dynamics within 3D human cells are lacking. Here, we introduce 3D-Spatial Assay for Replication Kinetics (3D-SPARK), an approach enabling nanoscale analysis synthesis situ. 3D-SPARK integrates optimised nucleotide analogue pulse labelling with super-resolution...
<title>Abstract</title> Intratumoral heterogeneity underlies therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC). GATA6 plays pivotal role regulating tumor cell plasticity the classical subtype of PDAC. Here we investigated immune features GATA6+ cells and exploited targeting strategies to enhance GATA6-dependent anti-tumor responses using preclinical PDAC models. Our findings revealed a positive correlation between expression presence CD4+, FOXP3+, CD20+, tumor-infiltrating...
<h3>Background</h3> Rheumatic diseases, such as rheumatoid arthritis and spondylarthritis, are chronic autoimmune diseases that can be treated with new biological drugs. <h3>Purpose</h3> The purpose of this study was to evaluate drug retention a surrogate for the effectiveness biologic therapy. <h3>Material methods</h3> In rheumatological centre in Apulia, Italy, 210 patients (RA) 336 spondylarthritis (SpA) were evaluated, following treatment 'biologics' from 1 January 2001 31 May 2016....
ESTRO 37 S366 organ involved mean survival was only 1,347 months (σ=0,53) and median 0,6 (σ=0,25).All but one patient in this group died the next three after begin of radiotherapy.The patient, from who survived more than 6 month had a relapse hormone positive breast cancer with malignant pleura effusion drainage.In Cox regression analysis age adjusted hazard ratio for death 6,7 (p<0,001) compared patients normal markers without extracranial involvement.The difference overall between two best...